PMID- 31002690
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 4
DP  - 2019
TI  - Microsatellite instability is inversely associated with type 2 diabetes mellitus 
      in colorectal cancer.
PG  - e0215513
LID - 10.1371/journal.pone.0215513 [doi]
LID - e0215513
AB  - BACKGROUND: Microsatellite instability (MSI) is a clonal change in the number of 
      repeated DNA nucleotide units in microsatellites. High-frequency MSI (MSI-H) 
      colorectal cancers (CRCs) are known to have different clinicopathological 
      features compared with microsatellite stable (MSS) CRCs. In addition, previous 
      studies have shown that type2 diabetes mellitus (T2DM) is a risk factor for 
      malignant tumors including CRCs. The aim of this study was to investigate the 
      relationship between T2DM and MSI-H colorectal cancer. METHODS: The study design 
      is a single center, cross-sectional study. Data from a series of 936 patients 
      with CRCs were collected and MSI status was assessed. RESULTS: In total, 29 
      (3.1%) and 907 (96.9%) tumors were classified as having MSI-H and low-frequency 
      microsatellite instability or being MSS (MSS), respectively. Of the 936 patients, 
      275 (29.6%) were associated with T2DM. One (3.4%) of the 29 MSI-H patients and 
      274 (30.2%) of the 907 MSS patients had T2DM. Thus, the incidence of T2DM was 
      significantly less frequent in MSI-H compared with MSS patients (Fisher's exact 
      test: p = 0.0007). CONCLUSIONS: We conclude that MSS tumors are significantly 
      more common than MSI-H tumors among individuals with T2DM.
FAU - Nakayama, Yujiro
AU  - Nakayama Y
AUID- ORCID: 0000-0002-0500-9691
AD  - Department of Surgery, Tokyo Metropolitan Cancer and Infectious diseases Center 
      Komagome Hospital, Tokyo, Japan.
AD  - Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical 
      University, Fukushima, Japan.
AD  - Department of Surgery, Southern Tohoku General Hospital, Fukushima, Japan.
FAU - Iijima, Takeru
AU  - Iijima T
AD  - Hereditary Tumor Research Project, Tokyo Metropolitan Cancer and Infectious 
      diseases Center Komagome Hospital, Tokyo, Japan.
FAU - Wakaume, Rika
AU  - Wakaume R
AD  - Hereditary Tumor Research Project, Tokyo Metropolitan Cancer and Infectious 
      diseases Center Komagome Hospital, Tokyo, Japan.
FAU - Takahashi, Keiichi
AU  - Takahashi K
AD  - Department of Surgery, Tokyo Metropolitan Cancer and Infectious diseases Center 
      Komagome Hospital, Tokyo, Japan.
FAU - Matsumoto, Hiroshi
AU  - Matsumoto H
AD  - Department of Surgery, Tokyo Metropolitan Cancer and Infectious diseases Center 
      Komagome Hospital, Tokyo, Japan.
FAU - Nakano, Daisuke
AU  - Nakano D
AD  - Department of Surgery, Tokyo Metropolitan Cancer and Infectious diseases Center 
      Komagome Hospital, Tokyo, Japan.
FAU - Miyaki, Michiko
AU  - Miyaki M
AD  - Hereditary Tumor Research Project, Tokyo Metropolitan Cancer and Infectious 
      diseases Center Komagome Hospital, Tokyo, Japan.
FAU - Yamaguchi, Tatsuro
AU  - Yamaguchi T
AD  - Department of Surgery, Tokyo Metropolitan Cancer and Infectious diseases Center 
      Komagome Hospital, Tokyo, Japan.
AD  - Hereditary Tumor Research Project, Tokyo Metropolitan Cancer and Infectious 
      diseases Center Komagome Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190419
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Colorectal Neoplasms/complications/*genetics
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Microsatellite Instability
MH  - Microsatellite Repeats/*genetics
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC6474599
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/04/20 06:00
MHDA- 2020/01/14 06:00
PMCR- 2019/04/19
CRDT- 2019/04/20 06:00
PHST- 2018/12/06 00:00 [received]
PHST- 2019/04/03 00:00 [accepted]
PHST- 2019/04/20 06:00 [entrez]
PHST- 2019/04/20 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/04/19 00:00 [pmc-release]
AID - PONE-D-18-34914 [pii]
AID - 10.1371/journal.pone.0215513 [doi]
PST - epublish
SO  - PLoS One. 2019 Apr 19;14(4):e0215513. doi: 10.1371/journal.pone.0215513. 
      eCollection 2019.