PMID- 31003049
OWN - NLM
STAT- MEDLINE
DCOM- 20190826
LR  - 20190826
IS  - 1873-3557 (Electronic)
IS  - 1386-1425 (Linking)
VI  - 218
DP  - 2019 Jul 5
TI  - Fourier transform infrared spectroscopy research on subchondral bone in 
      osteoarthritis.
PG  - 243-247
LID - S1386-1425(19)30395-6 [pii]
LID - 10.1016/j.saa.2019.04.020 [doi]
AB  - Osteoarthritis (OA) is not only related to the degradation of articular 
      cartilage, but also possibly to the changes of subchondral bone. The purpose of 
      this study was to assess whether specific differences could be resolved from bone 
      composition, as also contributed to OA. These differences were assessed by using 
      Fourier transform infrared spectroscopy (FTIRS). The main parameters including 
      mineral content, carbonate content, crystallinity, collagen cross-linking ratio 
      (XLR) and acid phosphate content were represented with characteristic peak 
      integration. It was found that mineral and carbonate content varied significantly 
      with depths at different OA stages. Mineral content increased with depth in 
      healthy samples, while carbonate content showed opposite trend. The mineral 
      content reduced obviously with OA duration, which was different with carbonate 
      decreasing only at early stage of OA. In addition, the content of acid phosphate, 
      collagen maturity (XLR) and crystallinity slight varied with the OA aggravation. 
      Therefore, the changes in subchondral bone were significantly associated with 
      cartilage degeneration and OA, the associated parameters should be targeted for 
      OA therapies.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Zhai, Mingyang
AU  - Zhai M
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing 210016, China.
FAU - Lu, Yanfei
AU  - Lu Y
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing 210016, China.
FAU - Fu, Juanjuan
AU  - Fu J
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing 210016, China.
FAU - Zhu, Yongkang
AU  - Zhu Y
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing 210016, China.
FAU - Zhao, Yuan
AU  - Zhao Y
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing 210016, China.
FAU - Shang, Linwei
AU  - Shang L
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing 210016, China.
FAU - Yin, Jianhua
AU  - Yin J
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing 210016, China. Electronic address: yin@nuaa.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190411
PL  - England
TA  - Spectrochim Acta A Mol Biomol Spectrosc
JT  - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
JID - 9602533
RN  - 0 (Carbonates)
RN  - 0 (Minerals)
RN  - 0 (Phosphates)
RN  - 9007-34-5 (Collagen)
RN  - 91D9GV0Z28 (Durapatite)
MH  - Animals
MH  - Bone and Bones/chemistry/*pathology
MH  - Carbonates/analysis
MH  - Collagen/analysis
MH  - Dogs
MH  - Durapatite/analysis
MH  - Minerals/analysis
MH  - Osteoarthritis/*pathology
MH  - Phosphates/analysis
MH  - Spectroscopy, Fourier Transform Infrared/*methods
OTO - NOTNLM
OT  - Collagen cross-link ratio
OT  - Crystallinity
OT  - Fourier transform infrared spectroscopy
OT  - Hydroxyapatite
OT  - Mineral content
OT  - Osteoarthritis
OT  - Subchondral bone
EDAT- 2019/04/20 06:00
MHDA- 2019/08/27 06:00
CRDT- 2019/04/20 06:00
PHST- 2018/11/22 00:00 [received]
PHST- 2019/04/10 00:00 [revised]
PHST- 2019/04/10 00:00 [accepted]
PHST- 2019/04/20 06:00 [pubmed]
PHST- 2019/08/27 06:00 [medline]
PHST- 2019/04/20 06:00 [entrez]
AID - S1386-1425(19)30395-6 [pii]
AID - 10.1016/j.saa.2019.04.020 [doi]
PST - ppublish
SO  - Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jul 5;218:243-247. doi: 
      10.1016/j.saa.2019.04.020. Epub 2019 Apr 11.