PMID- 31003153
OWN - NLM
STAT- MEDLINE
DCOM- 20191120
LR  - 20200106
IS  - 2299-5684 (Electronic)
IS  - 1734-1140 (Linking)
VI  - 71
IP  - 3
DP  - 2019 Jun
TI  - Hippocampal BDNF signaling is required for the antidepressant effects of 
      perillaldehyde.
PG  - 430-437
LID - S1734-1140(18)30555-3 [pii]
LID - 10.1016/j.pharep.2019.01.009 [doi]
AB  - BACKGROUND: Perillaldehyde is one of the main components in perilla. Previous 
      studies have shown that perillaldehyde exerted an antidepressant effect in mice, 
      some of which is mediated through regulation of the anti-inflammatory system and 
      the monoamine system. The primary objective of this study was to investigate the 
      possible effects of perillaldehyde on the neurotrophic system and to elucidate 
      whether its antidepressant effect requires brain-derived neurotrophic factor 
      (BDNF) signaling. METHODS: Mice were exposed to chronic unpredictable mild stress 
      (CUMS) and orally administrated with perillaldehyde for 4 weeks for behavioral 
      testing. RESULTS: Perillaldehyde not only reversed the decrease in sucrose 
      preference but also attenuated the increase in feeding latency. In addition, 
      perillaldehyde can attenuate the reduction of CUMS-induced hippocampal BDNF 
      levels. Our further study found that the BDNF receptor tropomyosin receptor 
      kinase B (TrkB) antagonist K252a completely blocked the antidepressant effect of 
      perillaldehyde in mice. Biochemical analysis showed that K252a pretreatment 
      completely prevented the improvement of BDNF, extracellular signal-regulated 
      kinase (ERK) phosphorylation and synaptic protein. CONCLUSIONS: These results 
      indicated that activation of BDNF-ERK signaling in the hippocampus was required, 
      at least in part for the antidepressant effects of perillaldehyde.
CI  - Copyright (c) 2019 Institute of Pharmacology, Polish Academy of Sciences. Published 
      by Elsevier B.V. All rights reserved.
FAU - Zhu, Ji-Xiao
AU  - Zhu JX
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China.
FAU - Hu, Wei-Qiong
AU  - Hu WQ
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China.
FAU - Dong, Shu-Qi
AU  - Dong SQ
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen, 361021, Fujian Province, PR China.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen, 361021, Fujian Province, PR China.
FAU - Zeng, Jin-Xiang
AU  - Zeng JX
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China.
FAU - Li, Min
AU  - Li M
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China. 
      Electronic address: 84492393@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20190116
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Antidepressive Agents)
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Monoterpenes)
RN  - 6EQL0XA86G (perillaldehyde)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Hippocampus/*drug effects/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Monoterpenes/*pharmacology
MH  - Phosphorylation/drug effects
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction/drug effects/*physiology
MH  - Stress, Psychological/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Chronic unpredictable mild stress
OT  - ERK
OT  - Perillaldehyde
OT  - TrkB
EDAT- 2019/04/20 06:00
MHDA- 2019/11/21 06:00
CRDT- 2019/04/20 06:00
PHST- 2018/09/11 00:00 [received]
PHST- 2019/01/04 00:00 [revised]
PHST- 2019/01/14 00:00 [accepted]
PHST- 2019/04/20 06:00 [pubmed]
PHST- 2019/11/21 06:00 [medline]
PHST- 2019/04/20 06:00 [entrez]
AID - S1734-1140(18)30555-3 [pii]
AID - 10.1016/j.pharep.2019.01.009 [doi]
PST - ppublish
SO  - Pharmacol Rep. 2019 Jun;71(3):430-437. doi: 10.1016/j.pharep.2019.01.009. Epub 
      2019 Jan 16.