PMID- 31003951 OWN - NLM STAT- MEDLINE DCOM- 20200316 LR - 20200316 IS - 2212-5353 (Electronic) IS - 2212-5345 (Linking) VI - 57 IP - 5 DP - 2019 Sep TI - Evaluation of changes in the serum levels of Krebs von den Lungen-6 and surfactant protein-D over time as important biomarkers in idiopathic fibrotic nonspecific interstitial pneumonia. PG - 422-429 LID - S2212-5345(19)30026-7 [pii] LID - 10.1016/j.resinv.2019.03.006 [doi] AB - BACKGROUND: Some cases of idiopathic fibrotic nonspecific interstitial pneumonia (f-NSIP) show a progressive course that is similar to that of idiopathic pulmonary fibrosis. However, it is difficult to predict poor patient outcomes. This study aimed to evaluate whether serial changes in serum levels of Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) can predict disease progression. METHODS: We retrospectively analyzed the medical records of 75 patients with idiopathic f-NSIP. Disease behavior was categorized into two groups depending on long-term change of pulmonary function: progressive type (>/=5%/year relative decline in the slope of forced vital capacity [FVC] and/or >/=7.5%/year relative decline in the slope of %diffusing capacity of the lung for carbon monoxide [%D(LCO)]) and stable type. Levels of KL-6 and SP-D and results of pulmonary function tests, which were performed parallelly, were reviewed and analyzed using a linear mixed-effects model. RESULTS: The study subjects comprised 62 patients with stable type and 13 patients with progressive type disease behavior. Among these subjects, 50 patients fulfilled the diagnostic criteria of interstitial pneumonia with autoimmune features (IPAF). Serum levels of both KL-6 and SP-D at baseline showed a negative correlation with %D(LCO), but not with FVC, and these biomarkers were not related to disease progression. Persistently high levels of KL-6 and SP-D correlated with progressive type disease behavior in idiopathic (non-IPAF) f-NSIP. CONCLUSIONS: Changes in serum KL-6 and SP-D levels over time may provide useful predictive information on disease behavior during treatment in patients with idiopathic f-NSIP and especially in those with non-IPAF f-NSIP. CI - Copyright (c) 2019 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved. FAU - Yamakawa, Hideaki AU - Yamakawa H AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan; Department of Respiratory Medicine, Saitama Red Cross Hospital, 1-5 Shintoshin, Chuo-ku, Saitama 330-8553, Japan. Electronic address: hide1144@jikei.ac.jp. FAU - Hagiwara, Eri AU - Hagiwara E AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: hagiwara@kanagawa-junko.jp. FAU - Ikeda, Satoshi AU - Ikeda S AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: isatoshi0112@gmail.com. FAU - Iwasawa, Tae AU - Iwasawa T AD - Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: iwasawa@kanagawa-junko.jp. FAU - Otoshi, Ryota AU - Otoshi R AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: ootoshi@kanagawa-junko.jp. FAU - Tabata, Erina AU - Tabata E AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: e-tabata@kanagawa-junko.jp. FAU - Okuda, Ryo AU - Okuda R AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: b980013@yahoo.co.jp. FAU - Sekine, Akimasa AU - Sekine A AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: akimasa.sekine@gmail.com. FAU - Baba, Tomohisa AU - Baba T AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: baba@kanagawa-junko.jp. FAU - Iso, Shinichiro AU - Iso S AD - Department of Radiology, Yokohama Rousai Hospital for Labour Welfare Corporation, 3211 Kozukue-machi, Kohoku-ku, Yokohama 222-0036, Japan. Electronic address: si999si999@gmail.com. FAU - Okudela, Koji AU - Okudela K AD - Department of Pathobiology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. Electronic address: krascv@yahoo.co.jp. FAU - Takemura, Tamiko AU - Takemura T AD - Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan. Electronic address: byori@med.jrc.or.jp. FAU - Ogura, Takashi AU - Ogura T AD - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address: ogura@kanagawa-junko.jp. LA - eng PT - Journal Article DEP - 20190416 PL - Netherlands TA - Respir Investig JT - Respiratory investigation JID - 101581124 RN - 0 (Biomarkers) RN - 0 (MUC1 protein, human) RN - 0 (Mucin-1) RN - 0 (Pulmonary Surfactant-Associated Protein D) SB - IM MH - Aged MH - Biomarkers/blood MH - Disease Progression MH - Female MH - Humans MH - Idiopathic Interstitial Pneumonias/*diagnosis MH - Idiopathic Pulmonary Fibrosis/*diagnosis MH - Male MH - Middle Aged MH - Mucin-1/*blood MH - Predictive Value of Tests MH - Pulmonary Surfactant-Associated Protein D/*blood MH - Retrospective Studies MH - Time Factors OTO - NOTNLM OT - Disease behavior OT - Idiopathic fibrotic nonspecific interstitial pneumonia OT - KL-6 OT - Surfactant protein-D EDAT- 2019/04/21 06:00 MHDA- 2020/03/17 06:00 CRDT- 2019/04/21 06:00 PHST- 2019/01/18 00:00 [received] PHST- 2019/02/26 00:00 [revised] PHST- 2019/03/15 00:00 [accepted] PHST- 2019/04/21 06:00 [pubmed] PHST- 2020/03/17 06:00 [medline] PHST- 2019/04/21 06:00 [entrez] AID - S2212-5345(19)30026-7 [pii] AID - 10.1016/j.resinv.2019.03.006 [doi] PST - ppublish SO - Respir Investig. 2019 Sep;57(5):422-429. doi: 10.1016/j.resinv.2019.03.006. Epub 2019 Apr 16.