PMID- 31004288
OWN - NLM
STAT- MEDLINE
DCOM- 20191226
LR  - 20191226
IS  - 2240-2993 (Electronic)
IS  - 0300-9009 (Linking)
VI  - 119
IP  - 2
DP  - 2019 Jun
TI  - Nocebo effect in myasthenia gravis: systematic review and meta-analysis of 
      placebo-controlled clinical trials.
PG  - 257-264
LID - 10.1007/s13760-019-01143-1 [doi]
AB  - Nocebo refers to the adverse events (AEs) experienced when taking a placebo drug 
      and is believed to be a centrally mediated process. We sought to examine the AEs 
      following placebo administration in Randomised Controlled Trials (RCTs) for 
      Myasthenia Gravis (MG) patients. A systematic literature search was performed on 
      Medline and Web of Science for RCTs for MG pharmacological treatments. We 
      assessed the number of placebo-treated patients reporting at least one AE and the 
      number of dropouts because of AEs. Data were extracted from six RCTs fulfilling 
      the search criteria. Four out of five placebo-treated participants (80.1%) 
      reported at least one AE and one in 40 (2.4%) discontinued placebo treatment 
      because of AE. All patients participating in the MG trials reported similar AEs 
      independent of the study arm to which they belonged (placebo or active 
      treatment). This meta-analysis demonstrates a low nocebo dropout rate in MG 
      compared to central nervous system disorders.
FAU - Varma, Adithya
AU  - Varma A
AD  - Sheffield Institute for Translational Neuroscience, Sheffield, UK.
FAU - Zis, Panagiotis
AU  - Zis P
AUID- ORCID: 0000-0001-8567-3092
AD  - Academic Department of Neurosciences, Sheffield Teaching Hospitals, NHS Trust, 
      Sheffield, UK. takiszis@gmail.com.
AD  - Medical School, University of Cyprus, Nicosia, Cyprus. takiszis@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190419
PL  - Italy
TA  - Acta Neurol Belg
JT  - Acta neurologica Belgica
JID - 0247035
RN  - 0 (Placebos)
SB  - IM
MH  - *Clinical Trials as Topic
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - MEDLINE
MH  - Myasthenia Gravis/diagnosis/*drug therapy
MH  - *Nocebo Effect
MH  - Placebos
OTO - NOTNLM
OT  - Adverse events
OT  - Myasthenia gravis
OT  - Nocebo
OT  - Placebo
OT  - Systematic review
EDAT- 2019/04/21 06:00
MHDA- 2019/12/27 06:00
CRDT- 2019/04/21 06:00
PHST- 2019/01/10 00:00 [received]
PHST- 2019/04/11 00:00 [accepted]
PHST- 2019/04/21 06:00 [pubmed]
PHST- 2019/12/27 06:00 [medline]
PHST- 2019/04/21 06:00 [entrez]
AID - 10.1007/s13760-019-01143-1 [pii]
AID - 10.1007/s13760-019-01143-1 [doi]
PST - ppublish
SO  - Acta Neurol Belg. 2019 Jun;119(2):257-264. doi: 10.1007/s13760-019-01143-1. Epub 
      2019 Apr 19.