PMID- 31004310
OWN - NLM
STAT- MEDLINE
DCOM- 20190718
LR  - 20200225
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 458
IP  - 1-2
DP  - 2019 Aug
TI  - Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor 
      glycemic control, accelerated cellular senescence and insulin resistance in 
      patients with type 2 diabetes.
PG  - 171-183
LID - 10.1007/s11010-019-03540-9 [doi]
AB  - There is a striking interaction of genes and environment in the etiology of type 
      2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like 
      bisphenol-A (BPA) have received special attention for their mechanistic role in 
      metabolic disruption, there is a lack of clinically relevant data on BPA levels 
      in Asian Indians, a population which is more susceptible to type 2 diabetes 
      mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic 
      levels of BPA in patients with T2DM compared to individuals with normal glucose 
      tolerance (n = 30 each). Serum BPA levels were estimated using ELISA kit, and 
      biochemical determinations were done by standard protocols. Peripheral blood 
      mononuclear cells (PBMCs) were used to profile the gene expression alterations 
      with special reference to inflammation, estrogen receptors, and cellular 
      senescence in these subjects. Serum levels of BPA were significantly higher in 
      patients with T2DM compared to control individuals and positively correlated to 
      poor glycemic control and insulin resistance. Patients with T2DM exhibited 
      significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and 
      inflammatory (IL6 and TNF-alpha) markers, shortened telomeres as well as elevated 
      levels of estrogen-related receptor gamma (ERRgamma), a recently identified receptor 
      for BPA. BPA levels were positively correlated to senescence indicators, 
      inflammatory markers and ERRgamma and negatively correlated to telomere length. Our 
      study is the first data in the clinical diabetes setting to demonstrate an 
      association of increased BPA levels with cellular senescence, proinflammation, 
      poor glycemic control, insulin resistance, and shortened telomeres in patients 
      with T2DM.
FAU - Soundararajan, Avinash
AU  - Soundararajan A
AD  - Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & 
      Dr. Mohan's Diabetes Specialties Centre, ICMR-Centre for Advanced Research on 
      Diabetes, Gopalapuram, Chennai, 600086, India.
AD  - Metabolic Research Unit, Metabolic Genetic Diseases Laboratory, School of 
      Medicine, Deakin University, 75 Pigdons Road, Waurn Ponds, VIC, 3216, Australia.
FAU - Prabu, Paramasivam
AU  - Prabu P
AD  - Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & 
      Dr. Mohan's Diabetes Specialties Centre, ICMR-Centre for Advanced Research on 
      Diabetes, Gopalapuram, Chennai, 600086, India.
FAU - Mohan, Viswanathan
AU  - Mohan V
AD  - Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & 
      Dr. Mohan's Diabetes Specialties Centre, ICMR-Centre for Advanced Research on 
      Diabetes, Gopalapuram, Chennai, 600086, India.
FAU - Gibert, Yann
AU  - Gibert Y
AD  - Metabolic Research Unit, Metabolic Genetic Diseases Laboratory, School of 
      Medicine, Deakin University, 75 Pigdons Road, Waurn Ponds, VIC, 3216, Australia.
AD  - Department of Cell and Molecular Biology, The University of Mississippi Medical 
      Center, Jackson, MS, 39216-4505, USA.
FAU - Balasubramanyam, Muthuswamy
AU  - Balasubramanyam M
AD  - Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & 
      Dr. Mohan's Diabetes Specialties Centre, ICMR-Centre for Advanced Research on 
      Diabetes, Gopalapuram, Chennai, 600086, India. balusignal@gmail.com.
LA  - eng
GR  - -/Department of Biotechnology , Ministry of Science and Technology/
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190420
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Biomarkers)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Adult
MH  - Benzhydryl Compounds/pharmacokinetics/*toxicity
MH  - Biomarkers/blood
MH  - Cellular Senescence/*drug effects
MH  - Diabetes Mellitus, Type 2/*blood/pathology
MH  - Female
MH  - Humans
MH  - Hyperglycemia/*blood/pathology
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Phenols/pharmacokinetics/*toxicity
MH  - Telomere Shortening/*drug effects
OTO - NOTNLM
OT  - Bisphenol-A
OT  - ERRgamma
OT  - Inflammation
OT  - Insulin resistance
OT  - Senescence
OT  - T2DM
EDAT- 2019/04/21 06:00
MHDA- 2019/07/19 06:00
CRDT- 2019/04/21 06:00
PHST- 2018/12/26 00:00 [received]
PHST- 2019/04/12 00:00 [accepted]
PHST- 2019/04/21 06:00 [pubmed]
PHST- 2019/07/19 06:00 [medline]
PHST- 2019/04/21 06:00 [entrez]
AID - 10.1007/s11010-019-03540-9 [pii]
AID - 10.1007/s11010-019-03540-9 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2019 Aug;458(1-2):171-183. doi: 10.1007/s11010-019-03540-9. 
      Epub 2019 Apr 20.