PMID- 31005464
OWN - NLM
STAT- MEDLINE
DCOM- 20200702
LR  - 20200702
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 208
DP  - 2019 Jun
TI  - Progressive reduction of auditory evoked gamma in first episode schizophrenia but 
      not clinical high risk individuals.
PG  - 145-152
LID - S0920-9964(19)30119-7 [pii]
LID - 10.1016/j.schres.2019.03.025 [doi]
AB  - The early auditory-evoked gamma band response (EAGBR) may serve as an index of 
      the integrity of fast recurrent inhibition or synaptic connectivity in the 
      auditory cortex, where abnormalities in individuals with schizophrenia have been 
      consistently found. The EAGBR has been rarely investigated in first episode 
      schizophrenia patients (FESZ) and individuals at clinical high risk (CHR) for 
      schizophrenia, and never been compared directly between these populations nor 
      evaluated longitudinally. Here we examined the EAGBR in FESZ, CHR, and matched 
      healthy controls (HC) at baseline and 1-year follow-up assessments to determine 
      whether the EAGBR was affected in these clinical groups, and whether any EAGBR 
      abnormalities changed over time. The electroencephalogram was recorded with a 
      dense electrode array while subjects (18 FESZ, 18 CHR, and 40 HC) performed an 
      auditory oddball task. Event-related spectral measures (phase locking factor 
      [PLF] and evoked power) were computed on Morlet-wavelet-transformed single epochs 
      from the standard trials. At baseline, EAGBR PLF and evoked power did not differ 
      between groups. FESZ showed progressive reductions of PLF and evoked power from 
      baseline to follow-up, and deficits in PLF at follow-up compared to HC. EAGBR 
      peak frequency also increased at temporal sites in FESZ from baseline to 
      follow-up. Longitudinal effects on the EAGBR were not found in CHR or HC, nor did 
      these groups differ at follow-up. In conclusion, we detected neurophysiological 
      changes of auditory cortex function in FESZ during a one-year period, which were 
      not observed in CHR. These findings are discussed within the context of 
      neurodevelopmental models of schizophrenia.
CI  - Published by Elsevier B.V.
FAU - Oribe, Naoya
AU  - Oribe N
AD  - Neural Dynamics Laboratory, Research Service, VA Boston Healthcare System, 
      Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of 
      Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Japan; 
      National Hospital Organization, Hizen Psychiatric Center, Japan.
FAU - Hirano, Yoji
AU  - Hirano Y
AD  - Neural Dynamics Laboratory, Research Service, VA Boston Healthcare System, 
      Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of 
      Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Japan.
FAU - Del Re, Elisabetta
AU  - Del Re E
AD  - Laboratory of Neuroscience, VA Boston Healthcare System, Department of 
      Psychiatry, Harvard Medical School, Brockton, MA, USA.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel 
      Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard 
      Medical School, Boston, MA, USA.
FAU - Mesholam-Gately, Raquelle I
AU  - Mesholam-Gately RI
AD  - Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel 
      Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard 
      Medical School, Boston, MA, USA.
FAU - Woodberry, Kristen A
AU  - Woodberry KA
AD  - Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel 
      Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard 
      Medical School, Boston, MA, USA.
FAU - Wojcik, Joanne D
AU  - Wojcik JD
AD  - Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel 
      Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard 
      Medical School, Boston, MA, USA.
FAU - Ueno, Takefumi
AU  - Ueno T
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan; National Hospital Organization, Hizen Psychiatric Center, 
      Japan.
FAU - Kanba, Shigenobu
AU  - Kanba S
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Onitsuka, Toshiaki
AU  - Onitsuka T
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Japan.
FAU - Shenton, Martha E
AU  - Shenton ME
AD  - Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, 
      Brigham and Women's Hospital, Boston, MA, USA.
FAU - Goldstein, Jill M
AU  - Goldstein JM
AD  - Departments of Psychiatry and Medicine, Harvard Medical School, Brigham and 
      Women's Hospital, Connors Center for Women's Health and Gender Biology, Boston, 
      MA, USA.
FAU - Niznikiewicz, Margaret A
AU  - Niznikiewicz MA
AD  - Laboratory of Neuroscience, VA Boston Healthcare System, Department of 
      Psychiatry, Harvard Medical School, Brockton, MA, USA.
FAU - McCarley, Robert W
AU  - McCarley RW
AD  - Laboratory of Neuroscience, VA Boston Healthcare System, Department of 
      Psychiatry, Harvard Medical School, Brockton, MA, USA.
FAU - Spencer, Kevin M
AU  - Spencer KM
AD  - Neural Dynamics Laboratory, Research Service, VA Boston Healthcare System, 
      Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic 
      address: kevin_spencer@hms.harvard.edu.
LA  - eng
GR  - K05 MH070047/MH/NIMH NIH HHS/United States
GR  - R01 MH052807/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01 MH080187/MH/NIMH NIH HHS/United States
GR  - R01 MH093450/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190417
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Brain/*physiopathology
MH  - *Evoked Potentials, Auditory
MH  - Female
MH  - Follow-Up Studies
MH  - *Gamma Rhythm
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Prodromal Symptoms
MH  - Risk
MH  - Schizophrenia/*physiopathology
MH  - Signal Processing, Computer-Assisted
MH  - Young Adult
OTO - NOTNLM
OT  - Clinical high risk
OT  - EEG
OT  - First episode schizophrenia
OT  - Gamma oscillation
EDAT- 2019/04/22 06:00
MHDA- 2020/07/03 06:00
CRDT- 2019/04/22 06:00
PHST- 2017/06/08 00:00 [received]
PHST- 2019/02/14 00:00 [revised]
PHST- 2019/03/26 00:00 [accepted]
PHST- 2019/04/22 06:00 [pubmed]
PHST- 2020/07/03 06:00 [medline]
PHST- 2019/04/22 06:00 [entrez]
AID - S0920-9964(19)30119-7 [pii]
AID - 10.1016/j.schres.2019.03.025 [doi]
PST - ppublish
SO  - Schizophr Res. 2019 Jun;208:145-152. doi: 10.1016/j.schres.2019.03.025. Epub 2019 
      Apr 17.