PMID- 31006313
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20210109
IS  - 1941-3084 (Electronic)
IS  - 1941-3149 (Print)
IS  - 1941-3084 (Linking)
VI  - 12
IP  - 5
DP  - 2019 May
TI  - Local Conduction Velocity in the Presence of Late Gadolinium Enhancement and 
      Myocardial Wall Thinning: A Cardiac Magnetic Resonance Study in a Swine Model of 
      Healed Left Ventricular Infarction.
PG  - e007175
LID - 10.1161/CIRCEP.119.007175 [doi]
AB  - BACKGROUND: Conduction velocity (CV) is an important property that contributes to 
      the arrhythmogenicity of the tissue substrate. The aim of this study was to 
      investigate the association between local CV versus late gadolinium enhancement 
      (LGE) and myocardial wall thickness in a swine model of healed left ventricular 
      infarction. METHODS: Six swine with healed myocardial infarction underwent 
      cardiovascular magnetic resonance imaging and electroanatomic mapping. Two 
      healthy controls (one treated with amiodarone and one unmedicated) underwent 
      electroanatomic mapping with identical protocols to establish the baseline CV. CV 
      was estimated using a triangulation technique. LGE+ regions were defined as 
      signal intensity >2 SD than the mean of remote regions, wall thinning+ as those 
      with wall thickness <2 SD than the mean of remote regions. LGE heterogeneity was 
      defined as SD of LGE in the local neighborhood of 5 mm and wall thickness 
      gradient as SD within 5 mm. Cardiovascular magnetic resonance and electroanatomic 
      mapping data were registered, and hierarchical modeling was performed to estimate 
      the mean difference of CV (LGE+/-, wall thinning+/-), or the change of the mean 
      of CV per unit change (LGE heterogeneity, wall thickness gradient). RESULTS: 
      Significantly slower CV was observed in LGE+ (0.33+/-0.25 versus 0.54+/-0.36 m/s; 
      P<0.001) and wall thinning+ regions (0.38+/-0.28 versus 0.55+/-0.37 m/s; P<0.001). 
      Areas with greater LGE heterogeneity ( P<0.001) and wall thickness gradient ( 
      P<0.001) exhibited slower CV. CONCLUSIONS: Slower CV is observed in the presence 
      of LGE, myocardial wall thinning, high LGE heterogeneity, and a high wall 
      thickness gradient. Cardiovascular magnetic resonance may offer a valuable 
      imaging surrogate for estimating CV, which may support noninvasive identification 
      of the arrhythmogenic substrate.
FAU - Jang, Jihye
AU  - Jang J
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
AD  - Department of Computer Science, Technical University of Munich, Germany (J.J., 
      B.M.).
FAU - Whitaker, John
AU  - Whitaker J
AD  - Division of Imaging Sciences and Biomedical Engineering, King's College London, 
      United Kingdom (J.W.).
FAU - Leshem, Eran
AU  - Leshem E
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
FAU - Ngo, Long H
AU  - Ngo LH
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
FAU - Neisius, Ulf
AU  - Neisius U
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
FAU - Nakamori, Shiro
AU  - Nakamori S
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
FAU - Pashakhanloo, Farhad
AU  - Pashakhanloo F
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
FAU - Menze, Bjoern
AU  - Menze B
AD  - Department of Computer Science, Technical University of Munich, Germany (J.J., 
      B.M.).
FAU - Manning, Warren J
AU  - Manning WJ
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
AD  - Department of Radiology (W.J.M.), Beth Israel Deaconess Medical Center and 
      Harvard Medical School, Boston, MA.
FAU - Anter, Elad
AU  - Anter E
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
FAU - Nezafat, Reza
AU  - Nezafat R
AD  - Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., 
      F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard 
      Medical School, Boston, MA.
LA  - eng
GR  - MR/N001877/1/MRC_/Medical Research Council/United Kingdom
GR  - R01 HL129157/HL/NHLBI NIH HHS/United States
GR  - R01 HL129185/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circ Arrhythm Electrophysiol
JT  - Circulation. Arrhythmia and electrophysiology
JID - 101474365
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
SB  - IM
MH  - *Action Potentials
MH  - Animals
MH  - Arrhythmias, Cardiac/*diagnostic imaging/etiology/physiopathology
MH  - Contrast Media/*administration & dosage
MH  - Disease Models, Animal
MH  - Electrophysiologic Techniques, Cardiac
MH  - Female
MH  - Heart Conduction System/*physiopathology
MH  - *Heart Rate
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Meglumine/administration & dosage/*analogs & derivatives
MH  - Myocardial Infarction/*complications/pathology/physiopathology
MH  - Myocardium/*pathology
MH  - Organometallic Compounds/*administration & dosage
MH  - Predictive Value of Tests
MH  - Sus scrofa
MH  - Time Factors
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
PMC - PMC6613809
MID - NIHMS1525682
OTO - NOTNLM
OT  - conduction velocity
OT  - electroanatomic mapping
OT  - late gadolinium enhancement
OT  - magnetic resonance imaging
OT  - myocardial infarction
OT  - myocardial wall thickness
OT  - ventricular tachycardia
EDAT- 2019/04/23 06:00
MHDA- 2020/01/28 06:00
PMCR- 2020/05/01
CRDT- 2019/04/23 06:00
PHST- 2019/04/23 06:00 [entrez]
PHST- 2019/04/23 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
AID - 10.1161/CIRCEP.119.007175 [doi]
PST - ppublish
SO  - Circ Arrhythm Electrophysiol. 2019 May;12(5):e007175. doi: 
      10.1161/CIRCEP.119.007175.