PMID- 31006380
OWN - NLM
STAT- MEDLINE
DCOM- 20191212
LR  - 20200225
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 47
IP  - 6
DP  - 2019 Jun
TI  - Aberrant functional connectivity density in patients with treatment-refractory 
      obsessive-compulsive disorder: a pilot study.
PG  - 2434-2445
LID - 10.1177/0300060518807058 [doi]
AB  - OBJECTIVE: Functional connectivity (FC) is altered in patients with 
      obsessive-compulsive disorder (OCD). Most previous studies have focused on the 
      strength of FC in patients with OCD; few have examined the number of functional 
      connections in these patients. The number of functional connections is an 
      important index for assessing aberrant FC. In the present study, we used FC 
      density (FCD) mapping to explore alterations in the number of functional 
      connections in patients with treatment-refractory OCD (TROCD) using the FCD 
      index. METHODS: Twenty patients with TROCD and 20 patients with OCD in clinical 
      remission were enrolled in the study. Global FCD (gFCD) was adopted to compare 
      the differences between the two groups of patients. RESULTS: The gFCD in the left 
      middle temporal gyrus was lower in the patients with TROCD than in those with 
      remitted OCD, suggesting that decreased information processing ability may play a 
      significant role in TROCD. CONCLUSION: The left middle temporal gyrus is a key 
      component of the emotional processing circuit and attentional processing circuit. 
      Decreased information processing ability in this brain region may play a 
      significant role in TROCD; however, further well-designed follow-up studies are 
      needed to support this hypothesis.
FAU - Shan, Pei Wei
AU  - Shan PW
AD  - 1 Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, China.
FAU - Liu, Wei
AU  - Liu W
AD  - 2 Department of Psychiatry, The First Affiliated Hospital of Harbin Medical 
      University, Harbin City, Heilongjiang Province, China.
FAU - Liu, Caixing
AU  - Liu C
AD  - 3 Department of Psychiatry, Qingdao Mental Health Center, Shandong Province, 
      China.
FAU - Han, Yunyi
AU  - Han Y
AD  - 1 Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, China.
FAU - Wang, Lina
AU  - Wang L
AD  - 4 Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health 
      Center, Tianjin City 300300, China.
FAU - Chen, Qinggang
AU  - Chen Q
AD  - 4 Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health 
      Center, Tianjin City 300300, China.
FAU - Tian, Hongjun
AU  - Tian H
AD  - 4 Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health 
      Center, Tianjin City 300300, China.
FAU - Sun, Xiuhai
AU  - Sun X
AD  - 5 Department of Neurology, Zoucheng People's Hospital, Jining Medical University 
      Affiliated to Zoucheng Hospital, Shandong Province, China.
FAU - Luan, Shuxin
AU  - Luan S
AD  - 6 Department of Psychiatry, Jilin University, Jinlin Province, China.
FAU - Lin, Xiaodong
AU  - Lin X
AD  - 1 Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, China.
FAU - Jiang, Deguo
AU  - Jiang D
AD  - 1 Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, China.
FAU - Zhuo, Chuanjun
AU  - Zhuo C
AD  - 1 Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, China.
AD  - 4 Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health 
      Center, Tianjin City 300300, China.
LA  - eng
PT  - Journal Article
DEP - 20190421
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - Brain Mapping/*methods
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Frontal Lobe/physiopathology
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Obsessive-Compulsive Disorder/classification/*etiology/metabolism/*pathology
MH  - Pilot Projects
MH  - Prefrontal Cortex/physiopathology
MH  - Prognosis
PMC - PMC6567710
OTO - NOTNLM
OT  - Treatment-refractory obsessive-compulsive disorder
OT  - aberrant functional connectivity
OT  - functional connection number
OT  - functional connectivity density
OT  - information processing
OT  - left middle temporal gyrus
EDAT- 2019/04/23 06:00
MHDA- 2019/12/18 06:00
PMCR- 2019/06/01
CRDT- 2019/04/23 06:00
PHST- 2019/04/23 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/04/23 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 10.1177_0300060518807058 [pii]
AID - 10.1177/0300060518807058 [doi]
PST - ppublish
SO  - J Int Med Res. 2019 Jun;47(6):2434-2445. doi: 10.1177/0300060518807058. Epub 2019 
      Apr 21.