PMID- 31006684
OWN - NLM
STAT- MEDLINE
DCOM- 20200910
LR  - 20200910
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 69
IP  - 2
DP  - 2019
TI  - Recruitment of Older Veterans with Diabetes Risk for Alzheimer's Disease for a 
      Randomized Clinical Trial of Computerized Cognitive Training.
PG  - 401-411
LID - 10.3233/JAD-180952 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is prevalent in the general United 
      States population, and in the veteran population. T2DM has consistently been 
      linked to increased risk for cognitive impairment, dementia, and Alzheimer's 
      disease. Computerized cognitive training (CCT) is practical and inexpensive 
      cognitive interventions that is an alternative to medication. OBJECTIVE: To 
      report the recruitment methods and challenges to date in an ongoing two-site 
      randomized controlled trial (RCT) of CCT on cognitive function and T2DM 
      management in an older non-demented veteran population. METHODS: Veterans are 
      recruited primarily by targeted mailings or by direct contact at clinics and 
      presentations. RESULTS: From 1,459 original contacts, 437 expressed initial 
      interest, 111 provided informed consent, and 97 completed baseline assessments. 
      Participants from the two VA Medical Centers differed in demographics and 
      baseline characteristics. Comparing recruitment methods, the proportion of 
      individuals contacted who were ultimately consented was significantly less from 
      mailings (5%) than other sources (20%), primarily face- to-face clinic visits (chi2 
      (1) = 38.331, p < 0.001). CONCLUSIONS: Mailings are cost-effective, but direct 
      contact improved recruitment. Not using or lacking access to computers and 
      ineligibility were major reasons for non-participation. Within-site comparisons 
      of demographically diverse sites can address confounding of demographic and other 
      site differences.
FAU - Karran, Martha
AU  - Karran M
AD  - James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
FAU - Guerrero-Berroa, Elizabeth
AU  - Guerrero-Berroa E
AD  - James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
AD  - Lehman College, City University of New York, Bronx, NY, USA.
FAU - Schmeidler, James
AU  - Schmeidler J
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Lee, Pearl G
AU  - Lee PG
AD  - University of Michigan, Ann Arbor, MI, USA.
AD  - Geriatric Research Education and Clinical Center, Veterans Affairs Ann Arbor 
      Health Care System, Ann Arbor, MI, USA.
FAU - Alexander, Neil
AU  - Alexander N
AD  - University of Michigan, Ann Arbor, MI, USA.
AD  - Geriatric Research Education and Clinical Center, Veterans Affairs Ann Arbor 
      Health Care System, Ann Arbor, MI, USA.
FAU - Nabozny, Martina
AU  - Nabozny M
AD  - University of Michigan, Ann Arbor, MI, USA.
AD  - Geriatric Research Education and Clinical Center, Veterans Affairs Ann Arbor 
      Health Care System, Ann Arbor, MI, USA.
FAU - West, Rebecca K
AU  - West RK
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Beeri, Michal Schnaider
AU  - Beeri MS
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Sano, Mary
AU  - Sano M
AD  - James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Silverman, Jeremy M
AU  - Silverman JM
AD  - James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
AD  - James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT01736124
GR  - I01 HX000828/HX/HSRD VA/United States
GR  - IK2 RX001190/RX/RRD VA/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/epidemiology/psychology/*therapy
MH  - Cognitive Behavioral Therapy/*methods/trends
MH  - Cognitive Dysfunction/epidemiology/psychology/*therapy
MH  - Diabetes Mellitus, Type 2/epidemiology/psychology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Status and Dementia Tests
MH  - Middle Aged
MH  - *Patient Selection
MH  - Risk Factors
MH  - Therapy, Computer-Assisted/*methods/trends
MH  - United States/epidemiology
MH  - United States Department of Veterans Affairs/trends
MH  - Veterans
OTO - NOTNLM
OT  - Cognition
OT  - computer games
OT  - research subject recruitment
OT  - type 2 diabetes mellitus
OT  - veterans
EDAT- 2019/04/23 06:00
MHDA- 2020/09/12 06:00
CRDT- 2019/04/23 06:00
PHST- 2019/04/23 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2019/04/23 06:00 [entrez]
AID - JAD180952 [pii]
AID - 10.3233/JAD-180952 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2019;69(2):401-411. doi: 10.3233/JAD-180952.