PMID- 31007172
OWN - NLM
STAT- MEDLINE
DCOM- 20200130
LR  - 20210109
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 405
DP  - 2019 May 1
TI  - Microglia in the Neurovascular Unit: Blood-Brain Barrier-microglia Interactions 
      After Central Nervous System Disorders.
PG  - 55-67
LID - S0306-4522(18)30464-0 [pii]
LID - 10.1016/j.neuroscience.2018.06.046 [doi]
AB  - Over the past few decades, microglial cells have been regarded as the main 
      executor of inflammation after acute and chronic central nervous system (CNS) 
      disorders, responding rapidly to exogenous stimuli during acute trauma or 
      infections, or signals released by cells undergoing cell death during conditions 
      such as stroke, Alzheimer's disease (AD) and Parkinson's disease (PD). Barriers 
      of the nervous system, and in particular the blood-brain barrier (BBB), play a 
      key role in the normal physiological and cognitive functions of the brain. Being 
      at the interface between the central and peripheral compartment, the BBB is 
      regarded as a sensor of homeostasis, and any disruption within the brain or the 
      systemic compartment triggers BBB dysfunction and neuroinflammation, both 
      contributing to the pathogenesis of cerebrovascular disease. This involves a 
      dynamic response mediated by all components of the neurovascular unit (NVU), and 
      ongoing research suggests that BBB-microglia interaction is critical to dictate 
      the microglial response to NVU injury. The present review aims to give an 
      up-to-date account of the emerging critical role of BBB-microglia interactions 
      during neuroinflammation, and how these could be targeted for the therapeutic 
      treatment of major central inflammatory disease.
CI  - Crown Copyright (c) 2018. Published by Elsevier Ltd. All rights reserved.
FAU - Thurgur, Hannah
AU  - Thurgur H
AD  - Faculty of Biology, Medicine and Health, AV Hill Building, The University of 
      Manchester, United Kingdom.
FAU - Pinteaux, Emmanuel
AU  - Pinteaux E
AD  - Faculty of Biology, Medicine and Health, AV Hill Building, The University of 
      Manchester, United Kingdom. Electronic address: 
      emmanuel.pinteaux@manchester.ac.uk.
LA  - eng
GR  - FS/17/6/32616/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180706
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*pathology
MH  - Brain/metabolism/pathology
MH  - Cell Communication/*physiology
MH  - Central Nervous System Diseases/*pathology
MH  - Cerebrovascular Disorders/pathology
MH  - Humans
MH  - Inflammation/pathology
MH  - Microglia/*pathology
OTO - NOTNLM
OT  - blood-brain barrier
OT  - endothelia
OT  - inflammation
OT  - microglia
OT  - neurovascular unit
EDAT- 2019/04/23 06:00
MHDA- 2020/01/31 06:00
CRDT- 2019/04/23 06:00
PHST- 2018/01/31 00:00 [received]
PHST- 2018/06/26 00:00 [revised]
PHST- 2018/06/27 00:00 [accepted]
PHST- 2019/04/23 06:00 [entrez]
PHST- 2019/04/23 06:00 [pubmed]
PHST- 2020/01/31 06:00 [medline]
AID - S0306-4522(18)30464-0 [pii]
AID - 10.1016/j.neuroscience.2018.06.046 [doi]
PST - ppublish
SO  - Neuroscience. 2019 May 1;405:55-67. doi: 10.1016/j.neuroscience.2018.06.046. Epub 
      2018 Jul 6.