PMID- 31007487
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1016-3190 (Print)
IS  - 2223-8956 (Electronic)
VI  - 31
IP  - 2
DP  - 2019 Apr-Jun
TI  - HLA-A*29:01-B*07:05-C*15:29*DRB1*10:01-DQB1*05:01, a deduced probable human 
      leukocyte antigen haplotype in association with a human leukocyte antigen-C 
      low-incidence allele C*15:29 in Taiwanese individuals.
PG  - 86-89
LID - 10.4103/tcmj.tcmj_111_18 [doi]
AB  - OBJECTIVE: HLA-C*15:29 is a low-frequency allele in the human leukocyte antigen 
      (HLA)-C locus. The aim of this study is to confirm the ethnicity of C*15:29 and 
      to deduce a probable HLA haplotype in association with C*15:29 in Taiwanese 
      population. MATERIALS AND METHODS: A total of 12,534 healthy unrelated Taiwanese 
      individuals were tested for HLA using a sequence-based typing method. The DNA 
      material was subjected to HLA genotyping for the HLA-A, HLA-B, HLA-C, HLA-DRB1, 
      and HLA-DQB1 loci using a commercial polymerase chain reaction-sequencing-based 
      typing kit as per the manufacturer's protocols. RESULTS: The DNA sequence of 
      C*15:29 is identical to C*15:02:01:01 in exons 1, 2, 3, 4, 5, and 6 except for 
      residues 420 and 1034 where A and G of C*15:02:01:01 are substituted by C and A 
      in C*15:29, respectively. The nucleotide substitutions introduce two amino acid 
      replacements at residues 116 and 321 where leucine (L) and cysteine (C) of 
      C*15:02:01:01 are replaced by phenylalanine (F) and tyrosine (Y) in C*15:29, 
      respectively. A probable HLA haplotype associated with C*15:29 in Taiwanese was 
      deduced as A*29:01-B*07:05-C*15:29-DRB1*10:01-DQB1*05:01. The frequency of 
      C*15:29 is estimated at about 0.064%. CONCLUSION: Information on the ethnicity 
      and distribution of C*15:29 and its deduced probable HLA haplotype is of value 
      for HLA testing laboratories for reference purposes and can help bone marrow 
      donor registries find compatible donors for patients with this uncommon HLA 
      allele.
FAU - Yang, Kuo-Liang
AU  - Yang KL
AD  - Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank and Buddhist Tzu Chi Marrow 
      Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi Hospital, 
      Hualien, Taiwan.
AD  - Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, 
      Taiwan.
FAU - Zheng, Zheng-Zhong
AU  - Zheng ZZ
AD  - Department of Research, China Shanghai Tissuebank Diagnostics, Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Ci Ji Yi Xue Za Zhi
JT  - Ci ji yi xue za zhi = Tzu-chi medical journal
JID - 9514171
PMC - PMC6450153
OTO - NOTNLM
OT  - HLA-C*15:29
OT  - Haplotype
OT  - Human leukocyte antigen
OT  - Taiwanese
OT  - Transplantation
COIS- There are no conflicts of interest.
EDAT- 2019/04/23 06:00
MHDA- 2019/04/23 06:01
PMCR- 2019/04/01
CRDT- 2019/04/23 06:00
PHST- 2019/04/23 06:00 [entrez]
PHST- 2019/04/23 06:00 [pubmed]
PHST- 2019/04/23 06:01 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - TCMJ-31-86 [pii]
AID - 10.4103/tcmj.tcmj_111_18 [doi]
PST - ppublish
SO  - Ci Ji Yi Xue Za Zhi. 2019 Apr-Jun;31(2):86-89. doi: 10.4103/tcmj.tcmj_111_18.