PMID- 31007634
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1555-1431 (Print)
IS  - 1555-1431 (Linking)
VI  - 12
IP  - 2
DP  - 2017
TI  - PROBIOTICS - A PROBABLE THERAPEUTIC AGENT FOR SPONDYLOARTHROPATHY.
PG  - 57-68
AB  - Spondyloarthropathy (SpA) or spondyloarthrosis refers to any joint disease of the 
      vertebral column. Among the entities of SpA, ankylosing spondylitis has drawn the 
      attention of some researchers, because of its specific mechanism of disease 
      progression. It has been studied earlier that its progression is due to the 
      presence of HLA (human leukocyte antigen) - B27. It shows molecular similarity 
      and immunological cross-reactivity with some of the gut microbiome. Since SpA 
      could be treated or its symptoms could be lessen by medications, but medications 
      itself show many side effects and other complications. Probiotic- being the 
      natural product has been found to be effective against many SpA entities, 
      including Ankylosing Spondylitis. It alters gut microflora somehow in such a way 
      that it helps in reducing the predisposition of any factor to SpA. Here we 
      consider the complex relationship between SpA pathogenesis and gut microbes; with 
      discussion that how use of probiotics as an alternative drug therapy may treat or 
      reduce the progression of SpA, which could be a better future target to treat SpA 
      entities.
FAU - Singh, Nandini
AU  - Singh N
AD  - Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, 
      INDIA.
FAU - Yadav, Hariom
AU  - Yadav H
AD  - Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
FAU - Marotta, Francesco
AU  - Marotta F
AD  - ReGenera Research Group for Aging Intervention & San Babila Clinic, Milano, 
      ITALY.
FAU - Singh, Vinod
AU  - Singh V
AD  - Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, 
      INDIA.
LA  - eng
GR  - Z99 DK999999/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20170821
PL  - United States
TA  - Int J Probiotics Prebiotics
JT  - International journal of probiotics & prebiotics
JID - 101283278
PMC - PMC6474668
MID - NIHMS991537
OTO - NOTNLM
OT  - Ankylosing Spondylitis
OT  - HLA B27
OT  - Probiotics
OT  - Spondyloarthropathy
COIS- CONFLICT OF INTEREST Authors declare no conflict of interest.
EDAT- 2017/01/01 00:00
MHDA- 2017/01/01 00:01
PMCR- 2019/04/19
CRDT- 2019/04/23 06:00
PHST- 2019/04/23 06:00 [entrez]
PHST- 2017/01/01 00:00 [pubmed]
PHST- 2017/01/01 00:01 [medline]
PHST- 2019/04/19 00:00 [pmc-release]
PST - ppublish
SO  - Int J Probiotics Prebiotics. 2017;12(2):57-68. Epub 2017 Aug 21.