PMID- 31009844
OWN - NLM
STAT- MEDLINE
DCOM- 20200415
LR  - 20200415
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 253
DP  - 2019 Jun 15
TI  - Altered whole brain functional connectivity pattern homogeneity in 
      medication-free major depressive disorder.
PG  - 18-25
LID - S0165-0327(19)30292-7 [pii]
LID - 10.1016/j.jad.2019.04.040 [doi]
AB  - BACKGROUND: Many previous studies have revealed abnormal functional connectivity 
      patterns between brain areas underlying the onset of major depressive disorder 
      (MDD) using resting-state functional magnetic resonance imaging (rs-fMRI). 
      However, how to exactly characterize the voxel-wise whole brain functional 
      connectivity pattern changes in MDD remains unclear, which will provide more 
      convincing evidence for localizing the exactly functional connectivity 
      abnormality in MDD. METHODS: In this study, we employed our newly developed whole 
      brain functional connectivity homogeneity (FcHo) method to identify the 
      voxel-wise changes of functional connectivity patterns in 27 medication-free MDD 
      patients and 34 gender-, age-, and education level-matched healthy controls (HC). 
      Furthermore, seed-based functional connectivity analysis was then used to 
      identify the alteration of corresponding functional connectivity. RESULTS: 
      Significantly decreased FcHo values in right ventral anterior insula (INS) and 
      medial prefrontal cortex (MPFC) were identified in MDD patients. The ensuing 
      functional connectivity analyses identified decreased functional connectivity 
      between MPFC and left angular gyrus (AG) in MDD patients. Moreover, both 
      decreased FcHo values in INS, MPFC and functional connectivity between MPFC and 
      left AG showed significant negative correlations with Hamilton depression rating 
      scale (HDRS) scores. The FcHo values in INS were also negatively correlated with 
      disease duration. Finally, meta-analysis based functional characterization found 
      that these brain areas are mainly involved in emotion, theory of mind and reward 
      processing. CONCLUSIONS: Our findings revealed abnormal whole brain FcHo in INS 
      and MPFC and functional interactions between MPFC and AG in MDD and suggested 
      that dysfunctions of INS and MPFC play an important role in the neuropathology of 
      MDD.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Wang, Lijie
AU  - Wang L
AD  - School of Computer Science and Engineering, University of Electronic Science and 
      Technology of China, Chengdu 611731, China. Electronic address: 
      ljwang@uestc.edu.cn.
FAU - Yu, Lin
AU  - Yu L
AD  - The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai 
      Hospital), Guangzhou 510370, China.
FAU - Wu, Fengchun
AU  - Wu F
AD  - The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai 
      Hospital), Guangzhou 510370, China; Guangdong Engineering Technology Research 
      Center for Translational Medicine of Mental Disorders, Guangzhou 510370, China.
FAU - Wu, Huawang
AU  - Wu H
AD  - The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai 
      Hospital), Guangzhou 510370, China; Guangdong Engineering Technology Research 
      Center for Translational Medicine of Mental Disorders, Guangzhou 510370, China. 
      Electronic address: huawangwu@126.com.
FAU - Wang, Jiaojian
AU  - Wang J
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, 610054, China. Electronic address: 
      jiaojianwang@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190408
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Brain/physiopathology
MH  - Cerebral Cortex/physiopathology
MH  - Depressive Disorder, Major/*physiopathology/psychology
MH  - Emotions
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Parietal Lobe/physiopathology
MH  - Prefrontal Cortex/physiopathology
MH  - Reward
MH  - Theory of Mind
OTO - NOTNLM
OT  - FcHo
OT  - Functional connectivity
OT  - Major depressive disorder
OT  - Resting-state
EDAT- 2019/04/23 06:00
MHDA- 2020/04/16 06:00
CRDT- 2019/04/23 06:00
PHST- 2019/02/01 00:00 [received]
PHST- 2019/03/11 00:00 [revised]
PHST- 2019/04/07 00:00 [accepted]
PHST- 2019/04/23 06:00 [pubmed]
PHST- 2020/04/16 06:00 [medline]
PHST- 2019/04/23 06:00 [entrez]
AID - S0165-0327(19)30292-7 [pii]
AID - 10.1016/j.jad.2019.04.040 [doi]
PST - ppublish
SO  - J Affect Disord. 2019 Jun 15;253:18-25. doi: 10.1016/j.jad.2019.04.040. Epub 2019 
      Apr 8.