PMID- 31011330
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20200309
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2019
DP  - 2019
TI  - Acupuncture Reversible Effects on Altered Default Mode Network of Chronic 
      Migraine Accompanied with Clinical Symptom Relief.
PG  - 5047463
LID - 10.1155/2019/5047463 [doi]
LID - 5047463
AB  - OBJECTIVE: To determine whether and how longitudinal acupuncture modulates the 
      impaired default mode network (DMN) in chronic migraine (CM) patients without 
      aura. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data 
      from 14 CM patients treated with longitudinal pre- and postacupuncture treatment 
      (PPAT) and data of 18 age- and gender-matched healthy controls (HCs) were 
      analyzed using independent component analysis (ICA) and seed-based correlation 
      analysis (SCA) to investigate connectivity within the DMN. Correlation analyses 
      were performed to identify associations between changes in functional 
      connectivity (FC) and in clinical pain based on PPAT observations. The monthly 
      mean visual analog scale (VAS) scores, monthly mean headache attacks, monthly 
      headache days, monthly amount of acute headache medications, and immediate VAS 
      scores were assessed for evaluation of pain. RESULTS: The decreased FC within the 
      DMN found in the left superior prefrontal gyrus (L_SPFG) and left precuneus 
      (L_PRECUN) of CM patients was returned to the healthy control level after 
      acupuncture treatments. Furthermore, the diminished pairwise FC strengths in some 
      regions of interest (ROIs) within the DMN were also increased, mainly distributed 
      between the right temporal lobe (R_TPL) and left anterior cingulate cortex, 
      between the R_TPL and bilateral superior medial gyrus, and between the R_TPL and 
      right precuneus. Increased z-scores within the DMN (L_SPFG and L_PRECUN) were 
      associated with reduced immediate VAS scores, and increases in z-scores of the 
      L_PRECUN were negatively correlated with reductions in the monthly amount of 
      acute headache medications. However, no association existed between the increased 
      DMN connectivity and reduced monthly mean VAS scores, monthly mean headache 
      attacks, and monthly headache days. CONCLUSION: Altered DMN connectivity and its 
      normalization postacupuncture can be employed to monitor CM and its modulating 
      effects. The DMN is useful for understanding the therapeutic mechanisms of 
      acupuncture in CM.
FAU - Zou, Yan
AU  - Zou Y
AD  - Department of Integrated Traditional and Western Medicine, Huashan Hospital, 
      Fudan University, Shanghai, China.
FAU - Tang, Weijun
AU  - Tang W
AD  - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Li, Xiang
AU  - Li X
AD  - Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Xu, Manwen
AU  - Xu M
AD  - Department of Integrated Traditional and Western Medicine, Huashan Hospital, 
      Fudan University, Shanghai, China.
FAU - Li, Ji
AU  - Li J
AUID- ORCID: 0000-0003-3179-933X
AD  - Department of Integrated Traditional and Western Medicine, Huashan Hospital, 
      Fudan University, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190318
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
SB  - IM
MH  - *Acupuncture Therapy
MH  - Adult
MH  - Brain/*physiopathology
MH  - Brain Mapping/methods
MH  - Chronic Disease/prevention & control
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*physiopathology/*prevention & control
MH  - Neural Pathways/physiopathology
MH  - Treatment Outcome
PMC - PMC6442315
EDAT- 2019/04/24 06:00
MHDA- 2019/12/18 06:00
PMCR- 2019/03/18
CRDT- 2019/04/24 06:00
PHST- 2018/08/28 00:00 [received]
PHST- 2018/12/20 00:00 [revised]
PHST- 2019/01/06 00:00 [accepted]
PHST- 2019/04/24 06:00 [entrez]
PHST- 2019/04/24 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/03/18 00:00 [pmc-release]
AID - 10.1155/2019/5047463 [doi]
PST - epublish
SO  - Neural Plast. 2019 Mar 18;2019:5047463. doi: 10.1155/2019/5047463. eCollection 
      2019.