PMID- 31012209
OWN - NLM
STAT- MEDLINE
DCOM- 20200421
LR  - 20200421
IS  - 1399-3046 (Electronic)
IS  - 1397-3142 (Linking)
VI  - 23
IP  - 4
DP  - 2019 Jun
TI  - Sirolimus-associated pericardial effusion with cardiac tamponade and interstitial 
      pneumonitis in a hematopoietic stem cell transplant recipient.
PG  - e13425
LID - 10.1111/petr.13425 [doi]
AB  - Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, is a potent 
      immunosuppressant that is increasingly used in prevention and treatment of 
      graft-vs-host disease (GVHD) in allogeneic hematopoietic stem cell transplant 
      (HSCT) patients. However, data regarding its adverse effects in HSCT patients 
      remain limited. We describe an 18-year-old HSCT patient with a history of 
      invasive fungal infection, who developed pericardial effusion with cardiac 
      tamponade and interstitial pneumonitis while receiving sirolimus for GVHD 
      prophylaxis. Our case illustrates potentially life-threatening complications of 
      sirolimus use in allogeneic HSCT patients.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Joo, Su Jin
AU  - Joo SJ
AUID- ORCID: 0000-0002-8811-7873
AD  - Division of Pediatric Infectious Diseases, Nationwide Children's Hospital, 
      Columbus, Ohio.
AD  - Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory 
      University School of Medicine, Atlanta, Georgia.
FAU - Yildirim, Inci
AU  - Yildirim I
AD  - Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory 
      University School of Medicine, Atlanta, Georgia.
AD  - Rollins School of Public Health, Department of Epidemiology, Emory University, 
      Atlanta, Georgia.
FAU - Stenger, Elizabeth O
AU  - Stenger EO
AD  - Division of Pediatric Hematology and Oncology, Emory University, Atlanta, 
      Georgia.
FAU - Anderson, Evan J
AU  - Anderson EJ
AD  - Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory 
      University School of Medicine, Atlanta, Georgia.
AD  - Division of Infectious Diseases, Department of Internal Medicine, Emory 
      University School of Medicine, Atlanta, Georgia.
LA  - eng
PT  - Case Reports
DEP - 20190423
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
RN  - 0 (Immunosuppressive Agents)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Adolescent
MH  - Cardiac Tamponade/*complications
MH  - Graft vs Host Disease/etiology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Immunosuppressive Agents/*adverse effects
MH  - Lung Diseases, Interstitial/*complications
MH  - Male
MH  - Mycoses/complications
MH  - Pericardial Effusion/*complications
MH  - Postoperative Complications/*diagnosis
MH  - Recurrence
MH  - Siblings
MH  - Sirolimus/*adverse effects
OTO - NOTNLM
OT  - adverse effects
OT  - aplastic anemia
OT  - cardiopulmonary toxicity
OT  - mTOR inhibitor
EDAT- 2019/04/24 06:00
MHDA- 2020/04/22 06:00
CRDT- 2019/04/24 06:00
PHST- 2018/06/23 00:00 [received]
PHST- 2019/02/10 00:00 [revised]
PHST- 2019/03/11 00:00 [accepted]
PHST- 2019/04/24 06:00 [pubmed]
PHST- 2020/04/22 06:00 [medline]
PHST- 2019/04/24 06:00 [entrez]
AID - 10.1111/petr.13425 [doi]
PST - ppublish
SO  - Pediatr Transplant. 2019 Jun;23(4):e13425. doi: 10.1111/petr.13425. Epub 2019 Apr 
      23.