PMID- 31012378
OWN - NLM
STAT- MEDLINE
DCOM- 20200526
LR  - 20231011
IS  - 1744-8069 (Electronic)
IS  - 1744-8069 (Linking)
VI  - 15
DP  - 2019 Jan-Dec
TI  - X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 
      activation.
PG  - 1744806919849201
LID - 10.1177/1744806919849201 [doi]
LID - 1744806919849201
AB  - Radiotherapy-related pain is a common adverse reaction with a high incidence 
      among cancer patients undergoing radiotherapy and remarkably reduces the quality 
      of life. However, the mechanisms of ionizing radiation-induced pain are largely 
      unknown. In this study, mice were treated with 20 Gy X-ray to establish ionizing 
      radiation-induced pain model. X-ray evoked a prolonged mechanical, heat, and cold 
      allodynia in mice. Transient receptor potential vanilloid 1 and transient 
      receptor potential ankyrin 1 were significantly upregulated in lumbar dorsal root 
      ganglion. The mechanical and heat allodynia could be transiently reverted by 
      intrathecal injection of transient receptor potential vanilloid 1 antagonist 
      capsazepine and transient receptor potential ankyrin 1 antagonist HC-030031. 
      Additionally, the phosphorylated extracellular regulated protein kinases (ERK) 
      and Jun NH2-terminal Kinase (JNK) in pain neural pathway were induced by X-ray 
      treatment. Our findings indicated that activation of transient receptor potential 
      ankyrin 1 and transient receptor potential vanilloid 1 is essential for the 
      development of X-ray-induced allodynia. Furthermore, our findings suggest that 
      targeting on transient receptor potential vanilloid 1 and transient receptor 
      potential ankyrin 1 may be promising prevention strategies for X-ray-induced 
      allodynia in clinical practice.
FAU - Cun-Jin, Su
AU  - Cun-Jin S
AUID- ORCID: 0000-0003-3728-3377
AD  - 1 Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
AD  - 2 Institute of Neuroscience, Soochow University, Suzhou, China.
FAU - Jian-Hao, Xu
AU  - Jian-Hao X
AD  - 3 Department of Oncology, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Xu, Liu
AU  - Xu L
AD  - 2 Institute of Neuroscience, Soochow University, Suzhou, China.
FAU - Feng-Lun, Zhao
AU  - Feng-Lun Z
AD  - 1 Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Jie, Pan
AU  - Jie P
AD  - 1 Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Ai-Ming, Shi
AU  - Ai-Ming S
AD  - 1 Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Duan-Min, Hu
AU  - Duan-Min H
AD  - 4 Department of Gastroenterology, The Second Affiliated Hospital of Soochow 
      University, Suzhou, China.
FAU - Yun-Li, Yu
AU  - Yun-Li Y
AD  - 5 Department of Clinical Pharmacology, The Second Affiliated Hospital of Soochow 
      University, Suzhou, China.
FAU - Tong, Liu
AU  - Tong L
AD  - 2 Institute of Neuroscience, Soochow University, Suzhou, China.
AD  - 6 College of Life Sciences, Yanan University, Yanan, China.
FAU - Yu-Song, Zhang
AU  - Yu-Song Z
AD  - 3 Department of Oncology, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Pain
JT  - Molecular pain
JID - 101242662
RN  - 0 (RNA, Messenger)
RN  - 0 (TRPA1 Cation Channel)
RN  - 0 (TRPV Cation Channels)
RN  - 0 (TRPV1 receptor)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Disease Models, Animal
MH  - Ganglia, Spinal/metabolism/pathology/radiation effects
MH  - *Hot Temperature
MH  - Hyperalgesia/*metabolism
MH  - *Ion Channel Gating/radiation effects
MH  - MAP Kinase Signaling System/radiation effects
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Neural Pathways/radiation effects
MH  - Oxidative Stress/radiation effects
MH  - Pain/metabolism/pathology
MH  - RNA, Messenger/genetics/metabolism
MH  - TRPA1 Cation Channel/antagonists & inhibitors/*metabolism
MH  - TRPV Cation Channels/antagonists & inhibitors/*metabolism
MH  - Time Factors
MH  - X-Rays
PMC - PMC6509987
OTO - NOTNLM
OT  - X-ray
OT  - dorsal root ganglion
OT  - pain
OT  - radiation
OT  - transient receptor potential ankyrin 1
OT  - transient receptor potential vanilloid 1
EDAT- 2019/04/24 06:00
MHDA- 2020/05/27 06:00
PMCR- 2019/05/09
CRDT- 2019/04/24 06:00
PHST- 2019/04/24 06:00 [pubmed]
PHST- 2020/05/27 06:00 [medline]
PHST- 2019/04/24 06:00 [entrez]
PHST- 2019/05/09 00:00 [pmc-release]
AID - 10.1177_1744806919849201 [pii]
AID - 10.1177/1744806919849201 [doi]
PST - ppublish
SO  - Mol Pain. 2019 Jan-Dec;15:1744806919849201. doi: 10.1177/1744806919849201.