PMID- 31013372 OWN - NLM STAT- MEDLINE DCOM- 20200601 LR - 20200601 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 30 IP - 6 DP - 2019 Sep TI - Parent and child perception of quality of life in a randomized controlled peanut oral immunotherapy trial. PG - 638-645 LID - 10.1111/pai.13066 [doi] AB - BACKGROUND: Improved quality of life (QoL) after oral immunotherapy (OIT) in peanut allergic children is often reported by their parents, while the child's perspective is less clear. OBJECTIVE: We aimed to explore whether 2 years of OIT improved QoL in children with peanut allergy and to identify factors influencing change in QoL. METHODS: In the open-labeled TAKE-AWAY peanut OIT trial including children with anaphylaxis to peanuts, 57 were randomized to OIT and 20 to observation. The Pediatric Quality of Life Inventory Version 4.0 was completed by parents and children at enrollment (Y(0) ), after 1 year (end of updosing; Y(1) ) and after 2 years (Y(2) ) of OIT. Minimally clinically important difference (MCID) is >/=5.3. Perceived treatment burden was recorded by visual analogue scales, including adverse events (AEs). An open food challenge (OFC) was performed at Y(2) . RESULTS: At Y(2) , 18 children had discontinued OIT and 2 of 39 OIT children refused OFC, while 35 of 37 were desensitized to 7500 mg peanut protein. From Y(0) to Y(2,) the mean change (95% confidence intervals) in QoL was 4.4 (0.5, 8.3) among child self-reports and twice as large among parental proxy reports (9.3 [4.3, 14.3]; both P < 0.0001), without significant improvement among the controls. The change in QoL was significantly different from the controls for the parental proxy reports only (P = 0.002). Neither treatment burden nor AEs significantly predicted changes in QoL. CONCLUSION: Two years of OIT improved child-QoL as reported by parents, but not by the children, suggesting that parents may overestimate improvement in child-QoL by OIT. CI - (c) 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. FAU - Reier-Nilsen, Tonje AU - Reier-Nilsen T AUID- ORCID: 0000-0001-8184-0607 AD - Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. FAU - Carlsen, Karin C Lodrup AU - Carlsen KCL AD - Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. FAU - Michelsen, Merethe Melbye AU - Michelsen MM AD - Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. FAU - Drottning, Sebastian AU - Drottning S AD - Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Carlsen, Kai-Hakon AU - Carlsen KH AD - Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. FAU - Zhang, Chi AU - Zhang C AD - Department of Biostatistics, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. FAU - Borres, Magnus P AU - Borres MP AUID- ORCID: 0000-0002-9045-2304 AD - Thermo-Fisher Scientific, Uppsala, Sweden. AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Haland, Geir AU - Haland G AD - Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. LA - eng SI - ClinicalTrials.gov/NCT02457416 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20190725 PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 0 (Allergens) RN - 0 (Antigens, Plant) SB - IM MH - Administration, Oral MH - Adolescent MH - Allergens/immunology MH - Antigens, Plant/immunology MH - Arachis/immunology MH - Child MH - Child, Preschool MH - Desensitization, Immunologic/*methods MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - *Parents MH - Peanut Hypersensitivity/immunology/*therapy MH - Perception MH - Quality of Life MH - Surveys and Questionnaires OTO - NOTNLM OT - child OT - desensitization OT - double-blind placebo-controlled food challenge OT - oral immunotherapy OT - peanut allergy OT - perceived treatment burden OT - quality of life OT - self- and proxy reports OT - visual analogue scale EDAT- 2019/04/24 06:00 MHDA- 2020/06/02 06:00 CRDT- 2019/04/24 06:00 PHST- 2018/12/03 00:00 [received] PHST- 2019/04/12 00:00 [revised] PHST- 2019/04/15 00:00 [accepted] PHST- 2019/04/24 06:00 [pubmed] PHST- 2020/06/02 06:00 [medline] PHST- 2019/04/24 06:00 [entrez] AID - 10.1111/pai.13066 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2019 Sep;30(6):638-645. doi: 10.1111/pai.13066. Epub 2019 Jul 25.