PMID- 31013790
OWN - NLM
STAT- MEDLINE
DCOM- 20190814
LR  - 20200225
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 8
DP  - 2019 Apr 12
TI  - Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside 
      Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus.
LID - 10.3390/molecules24081454 [doi]
LID - 1454
AB  - Rheum palmatum L. is a traditional Chinese medicine with various pharmacological 
      properties, including anti-inflammatory, antibacterial, and detoxification 
      effects. In this study, the mechanism of the hypoglycemic effect of purified 
      anthraquinone-Glycoside from Rheum palmatum L. (PAGR) in streptozotocin (STZ) and 
      high-fat diet induced type 2 diabetes mellitus (T2DM) in rats was investigated. 
      The rats were randomly divided into normal (NC), T2DM, metformin (Met), low, 
      middle (Mid), and high (Hig) does of PAGR groups. After six weeks of continuous 
      administration of PAGR, the serum indices and tissue protein expression were 
      determined, and the pathological changes in liver, kidney, and pancreas tissues 
      were observed. The results showed that compared with the type 2 diabetes mellitus 
      group, the fasting blood glucose (FBG), total cholesterol (TC), and triglyceride 
      (TG) levels in the serum of rats in the PAGR treatment groups were significantly 
      decreased, while superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) 
      levels were noticeably increased. The expression of Fas ligand (FasL), cytochrome 
      C (Cyt-c), and caspase-3 in pancreatic tissue was obviously decreased, and the 
      pathological damage to the liver, kidney, and pancreas was improved. These 
      indicate that PAGR can reduce oxidative stress in rats with diabetes mellitus by 
      improving blood lipid metabolism and enhancing their antioxidant capacity, 
      thereby regulating the mitochondrial apoptotic pathway to inhibitbeta-cell apoptosis 
      and improve beta-cell function. Furthermore, it can regulate Fas/FasL-mediated 
      apoptosis signaling pathway to inhibit beta-cell apoptosis, thereby lowering blood 
      glucose levels and improving T2DM.
FAU - Cheng, Fang-Rong
AU  - Cheng FR
AD  - College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, 
      China. chengfr1963888@126.com.
FAU - Cui, Hong-Xin
AU  - Cui HX
AD  - College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, 
      China. cuihongxin1974@163.com.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. 
      cuihongxin1974@163.com.
FAU - Fang, Ji-Li
AU  - Fang JL
AD  - Jiyang College of Zhejiang Agriculture and Forestry University, Zhu'ji 311800, 
      China. fang_qiao418@163.com.
FAU - Yuan, Ke
AU  - Yuan K
AD  - Jiyang College of Zhejiang Agriculture and Forestry University, Zhu'ji 311800, 
      China. keyuan@zafu.edu.cn.
FAU - Guo, Ying
AU  - Guo Y
AD  - Zhejiang Chinese Medical University, Zhejiang, Hangzhou 310053, China. 
      littlegy@163.com.
LA  - eng
GR  - Grant No: LY16H280007/Zhejiang Provincial Science Foundation of China/
PT  - Journal Article
DEP - 20190412
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anthraquinones)
RN  - 0 (Antioxidants)
RN  - 0 (Glucosides)
RN  - 0 (Hypoglycemic Agents)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
MH  - Animals
MH  - *Anthraquinones/chemistry/isolation & purification/pharmacology
MH  - *Antioxidants/chemistry/isolation & purification/pharmacology
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism/pathology
MH  - Diabetes Mellitus, Type 2
MH  - *Glucosides/chemistry/isolation & purification/pharmacology
MH  - *Hypoglycemic Agents/chemistry/isolation & purification/pharmacology
MH  - Lipid Metabolism/drug effects
MH  - Liver/metabolism/pathology
MH  - Male
MH  - Oxidative Stress/drug effects
MH  - Pancreas/metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rheum/*chemistry
MH  - Superoxide Dismutase/metabolism
PMC - PMC6515271
OTO - NOTNLM
OT  - Rheum palmatum L.
OT  - apoptosis
OT  - oxidative stress
OT  - type 2 diabetes mellitus
COIS- The authors have no conflicts of interest to declare. All of the authors have 
      approved the final article.
EDAT- 2019/04/25 06:00
MHDA- 2019/08/15 06:00
PMCR- 2019/04/12
CRDT- 2019/04/25 06:00
PHST- 2019/02/28 00:00 [received]
PHST- 2019/03/27 00:00 [revised]
PHST- 2019/04/04 00:00 [accepted]
PHST- 2019/04/25 06:00 [entrez]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2019/08/15 06:00 [medline]
PHST- 2019/04/12 00:00 [pmc-release]
AID - molecules24081454 [pii]
AID - molecules-24-01454 [pii]
AID - 10.3390/molecules24081454 [doi]
PST - epublish
SO  - Molecules. 2019 Apr 12;24(8):1454. doi: 10.3390/molecules24081454.