PMID- 31014242
OWN - NLM
STAT- MEDLINE
DCOM- 20200128
LR  - 20200930
IS  - 1471-2202 (Electronic)
IS  - 1471-2202 (Linking)
VI  - 20
IP  - 1
DP  - 2019 Apr 24
TI  - Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent 
      stress-induced enhanced mechanical allodynia in a rat model of burn pain.
PG  - 17
LID - 10.1186/s12868-019-0500-1 [doi]
LID - 17
AB  - BACKGROUND: Reports show that stressful events before injury exacerbates 
      post-injury pain. The mechanism underlying stress-induced heightened thermal pain 
      is unclear. Here, we examined the effects of chronic intermittent stress (CIS) on 
      nociceptive behaviors and brain-derived nerve growth factor (BDNF) system in the 
      prefrontal cortex (PFC) and hypothalamus of rats with and without thermal injury. 
      RESULTS: Unstressed rats showed transient mechanical allodynia during stress 
      exposure. Stressed rats with thermal injury displayed persistent exacerbated 
      mechanical allodynia (P < 0.001). Increased expression of BDNF mRNA in the PFC 
      (P < 0.05), and elevated TrkB and p-TrkB (P < 0.05) protein levels in the 
      hypothalamus were observed in stressed rats with thermal injury but not in 
      stressed or thermally injured rats alone. Furthermore, administration of CTX-B 
      significantly reduced stress-induced exacerbated mechanical allodynia in 
      thermally injured rats (P < 0.001). CONCLUSION: These results indicate that 
      BDNF-TrkB signaling in PFC and hypothalamus contributes to CIS-induced 
      exacerbated mechanical allodynia in thermal injury state.
FAU - Sosanya, Natasha M
AU  - Sosanya NM
AD  - Battlefield Pain Management Research Group, United States Army Institute of 
      Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, San Antonio, TX, 
      78234-4504, USA.
FAU - Garza, Thomas H
AU  - Garza TH
AD  - Battlefield Pain Management Research Group, United States Army Institute of 
      Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, San Antonio, TX, 
      78234-4504, USA.
FAU - Stacey, Winfred
AU  - Stacey W
AD  - Battlefield Pain Management Research Group, United States Army Institute of 
      Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, San Antonio, TX, 
      78234-4504, USA.
FAU - Crimmins, Stephen L
AU  - Crimmins SL
AD  - Battlefield Pain Management Research Group, United States Army Institute of 
      Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, San Antonio, TX, 
      78234-4504, USA.
FAU - Christy, Robert J
AU  - Christy RJ
AD  - Battlefield Pain Management Research Group, United States Army Institute of 
      Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, San Antonio, TX, 
      78234-4504, USA.
FAU - Cheppudira, Bopaiah P
AU  - Cheppudira BP
AUID- ORCID: 0000-0001-8352-7729
AD  - Battlefield Pain Management Research Group, United States Army Institute of 
      Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, San Antonio, TX, 
      78234-4504, USA. bopaiah.p.cheppudira.ctr@mail.mil.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190424
PL  - England
TA  - BMC Neurosci
JT  - BMC neuroscience
JID - 100966986
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (cyclotraxin-B)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Burns/complications/physiopathology
MH  - Hyperalgesia/complications/*metabolism/physiopathology/prevention & control
MH  - Hypothalamus/metabolism
MH  - Male
MH  - Pain/complications/*physiopathology
MH  - Peptides, Cyclic/pharmacology
MH  - Phosphorylation
MH  - Prefrontal Cortex/metabolism
MH  - Rats
MH  - Receptor, trkB/metabolism
MH  - Stress, Physiological/*physiology
PMC - PMC6480655
OTO - NOTNLM
OT  - BDNF
OT  - Chronic intermittent stress
OT  - Cyclotraxin-B
OT  - Mechanical allodynia
OT  - Thermal injury
OT  - TrkB
OT  - p-TrkB
COIS- The opinions or assertions contained herein are the private views of the authors 
      and are not to be considered as official or as reflecting the views of the 
      Department of the Army or the Department of Defense. The authors declare that 
      they have no financial competing interests.
EDAT- 2019/04/25 06:00
MHDA- 2020/01/29 06:00
PMCR- 2019/04/24
CRDT- 2019/04/25 06:00
PHST- 2018/06/13 00:00 [received]
PHST- 2019/04/10 00:00 [accepted]
PHST- 2019/04/25 06:00 [entrez]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2020/01/29 06:00 [medline]
PHST- 2019/04/24 00:00 [pmc-release]
AID - 10.1186/s12868-019-0500-1 [pii]
AID - 500 [pii]
AID - 10.1186/s12868-019-0500-1 [doi]
PST - epublish
SO  - BMC Neurosci. 2019 Apr 24;20(1):17. doi: 10.1186/s12868-019-0500-1.