PMID- 31014571
OWN - NLM
STAT- MEDLINE
DCOM- 20200612
LR  - 20200612
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 74
IP  - 8
DP  - 2019 Aug
TI  - Image quality and radiation dose of renal perfusion CT with low-dose contrast 
      agent: a comparison with conventional CT using a 320-row system.
PG  - 650.e13-650.e18
LID - S0009-9260(19)30161-8 [pii]
LID - 10.1016/j.crad.2019.03.017 [doi]
AB  - AIM: To compare perfusion computed tomography (CT) with reconstructed image from 
      source data using low-dose contrast agent and conventional 320-row CT for the 
      evaluation of renal tumours. MATERIALS AND METHODS: Twenty-eight patients 
      underwent conventional CT (C-CT) and 26 patients underwent perfusion CT with 
      low-dose (40 ml) contrast agent. Image noise, arterial visualisation, the 
      sharpness of the corticomedullary junction (CMJ), and overall image quality were 
      each assessed using a four-point scale. The tumour detection rate for lesions <4 
      cm (n=66) was also evaluated. Quantitative image parameters including image noise 
      and the contrast-to-noise ratios (CNRs) of the renal artery and CMJ were 
      measured. The volume CT dose index (CTDI), dose-length product (DLP), and 
      size-specific dose estimate (SSDE) were also recorded. RESULTS: Although the 
      image noise of perfusion CT was higher than that of C-CT and the overall image 
      quality of perfusion CT was lower than that of C-CT, the arterial visualisation 
      score of perfusion CT was significantly higher than that of C-CT. The CMJ 
      sharpness scores of the two techniques were equivalent. Sensitivity and positive 
      predictive values were also equivalent with respect to tumour detection. The CNRs 
      of both the left and right renal arteries were significantly higher on perfusion 
      CT than on C-CT. The CTDI, DLP, and SSDE of perfusion CT were significantly lower 
      than those of C-CT. CONCLUSION: Perfusion CT using low-dose contrast agent 
      preserved arterial visualisation and the tumour detection rate and achieved a low 
      radiation dose despite image quality degradation and image noise.
CI  - Copyright (c) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Asayama, Y
AU  - Asayama Y
AD  - Department of Advanced Imaging and Interventional Radiology, Graduate School of 
      Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 
      812-8582, Japan. Electronic address: asayama@radiol.med.kyushu-u.ac.jp.
FAU - Nishie, A
AU  - Nishie A
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Ishigami, K
AU  - Ishigami K
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Ushijima, Y
AU  - Ushijima Y
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Kakihara, D
AU  - Kakihara D
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Fujita, N
AU  - Fujita N
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Morita, K
AU  - Morita K
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Ishimatsu, K
AU  - Ishimatsu K
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Takao, S
AU  - Takao S
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Honda, H
AU  - Honda H
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190420
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - *Contrast Media
MH  - Female
MH  - Humans
MH  - Kidney/diagnostic imaging
MH  - Kidney Neoplasms/*diagnostic imaging
MH  - Male
MH  - Perfusion Imaging/methods
MH  - *Radiation Dosage
MH  - Radiographic Image Enhancement/*methods
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2019/04/25 06:00
MHDA- 2020/06/13 06:00
CRDT- 2019/04/25 06:00
PHST- 2018/04/04 00:00 [received]
PHST- 2019/03/20 00:00 [accepted]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2020/06/13 06:00 [medline]
PHST- 2019/04/25 06:00 [entrez]
AID - S0009-9260(19)30161-8 [pii]
AID - 10.1016/j.crad.2019.03.017 [doi]
PST - ppublish
SO  - Clin Radiol. 2019 Aug;74(8):650.e13-650.e18. doi: 10.1016/j.crad.2019.03.017. 
      Epub 2019 Apr 20.