PMID- 31015098
OWN - NLM
STAT- MEDLINE
DCOM- 20200625
LR  - 20221207
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 114
DP  - 2019 Jul
TI  - Manual or electroacupuncture as an add-on therapy to SSRIs for depression: A 
      randomized controlled trial.
PG  - 24-33
LID - S0022-3956(18)31294-9 [pii]
LID - 10.1016/j.jpsychires.2019.04.005 [doi]
AB  - Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants, 
      however, only around 60% of patients could benefit from them. Acupuncture is 
      supported by insufficient evidence to help with symptom relieving and SSRIs 
      tolerance. This pragmatic randomized controlled trial compared SSRIs alone versus 
      SSRIs together with manual acupuncture (MA) or electroacupuncture (EA) in 
      moderate to severe depressed patients. Patients were randomly allocated to 
      receive MA + SSRIs (161), EA + SSRIs (160), or SSRIs alone (156) for six weeks, 
      and then followed up for another four weeks. The primary outcome was response 
      rate of the 17-item Hamilton Depression Scale (HAMD-17) at 6th week. The 
      secondary outcomes were HAMD-17 (remission rate, early onset rate, total score), 
      Self-Rating Depression Scale (SDS: total score), Clinical Global Impression 
      (CGI), Rating Scale for Side Effects (SERS: total and domain scores), number of 
      patients with adjusted dosage of SSRIs and adverse events (AEs). Both MA + SSRIs 
      and EA + SSRIs were significantly better than SSRIs at 6th week on HAMD-17 
      response rate (RR = 1.21, 95% CI 1.04, 1.42, P = 0.013; RR = 1.27, 95% CI 1.09, 
      1.48, P = 0.0014), HAMD-17 early onset rate (P < 0.0001), HAMD-17 and SDS total 
      scores (P < 0.05), CGI (P < 0.01), SERS total score (P < 0.01), number of 
      patients with increased dosage of SSRIs (P < 0.01). For HAMD-17 remission rate, 
      EA + SSRIs was significantly higher than SSRIs (P = 0.0083), while MA + SSRIs 
      showed no significant difference at 6th week (P = 0.092). No unintended 
      acupuncture-related severe AE was observed. This study identified that both MA 
      and EA showed beneficial effects in addition to SSRIs alone in patients with 
      moderate to severe depression, and were well tolerated. Clinical trials 
      registration: ChiCTR-TRC-08000297.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Zhao, Bingcong
AU  - Zhao B
AD  - Beijing University of Chinese Medicine, School of Acupuncture-Moxibustion and 
      Tuina, Beijing, 100029, China; Capital Medical University, Beijing Hospital of 
      Traditional Chinese Medicine, Department of Acupuncture and Moxibustion, Beijing 
      Key Laboratory of Acupuncture Neuromodulation, Beijing, 100010, China.
FAU - Li, Zhigang
AU  - Li Z
AD  - Beijing University of Chinese Medicine, School of Acupuncture-Moxibustion and 
      Tuina, Beijing, 100029, China.
FAU - Wang, Yuanzheng
AU  - Wang Y
AD  - (c)Peking University First Hospital, Department of Integrative TCM and Western 
      Medicine, Beijing, 100034, China.
FAU - Ma, Xuehong
AU  - Ma X
AD  - (d)Dongfang Hospital, The Second Clinical Medical College of Beijing University 
      of Chinese Medicine, Department of Acupuncture & Moxibustion, Beijing, 100078, 
      China.
FAU - Wang, Xiangqun
AU  - Wang X
AD  - (e)Peking University Sixth Hospital, Department of Psychiatry, Beijing, 100191, 
      China.
FAU - Wang, Xueqin
AU  - Wang X
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      NHC Key Laboratory of Mental Health (Peking University), National Clinical 
      Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 
      100191, China.
FAU - Liu, Jianping
AU  - Liu J
AD  - Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese 
      Medicine, Beijing, 100029, China.
FAU - Huang, Yong
AU  - Huang Y
AD  - Southern Medical University, TCM School, Guangzhou, 510515, China.
FAU - Zhang, Jianbin
AU  - Zhang J
AD  - The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu 
      Provincial Second Chinese Medicine Hospital, The Acuology Department, Nanjing, 
      210017, China.
FAU - Li, Liqin
AU  - Li L
AD  - Sixth Hospital of Baotou, Department of Psychiatry, Baotou, 014060, China.
FAU - Hu, Xiaoyang
AU  - Hu X
AD  - University of Southampton, Aldermoor Health Centre, Primary Care and Population 
      Sciences, Southampton, SO16 5ST, United Kingdom.
FAU - Jiang, Jinfeng
AU  - Jiang J
AD  - Nanjing University of Chinese Medicine, Key Laboratory of Acupuncture and 
      Medicine Research of Minister of Education, Nanjing, 210023, China.
FAU - Qu, Shanshan
AU  - Qu S
AD  - Southern Medical University, TCM School, Guangzhou, 510515, China.
FAU - Chai, Qianyun
AU  - Chai Q
AD  - Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese 
      Medicine, Beijing, 100029, China.
FAU - Song, Meng
AU  - Song M
AD  - Beijing University of Chinese Medicine, School of Acupuncture-Moxibustion and 
      Tuina, Beijing, 100029, China.
FAU - Yang, Xinjing
AU  - Yang X
AD  - Beijing University of Chinese Medicine, School of Acupuncture-Moxibustion and 
      Tuina, Beijing, 100029, China.
FAU - Bao, Tuya
AU  - Bao T
AD  - Beijing University of Chinese Medicine, School of Acupuncture-Moxibustion and 
      Tuina, Beijing, 100029, China. Electronic address: tuyab@bucm.edu.cn.
FAU - Fei, Yutong
AU  - Fei Y
AD  - Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese 
      Medicine, Beijing, 100029, China. Electronic address: feiyt@bucm.edu.cn.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Pragmatic Clinical Trial
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20190409
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Antidepressive Agents)
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Acupuncture Therapy/*methods
MH  - Adult
MH  - Antidepressive Agents/*therapeutic use
MH  - Combined Modality Therapy
MH  - Depression/drug therapy/*therapy
MH  - Electroacupuncture/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Selective Serotonin Reuptake Inhibitors/*therapeutic use
MH  - Young Adult
OTO - NOTNLM
OT  - Acupuncture
OT  - Depression
OT  - Randomized controlled trial
OT  - SSRIs
EDAT- 2019/04/25 06:00
MHDA- 2020/06/26 06:00
CRDT- 2019/04/25 06:00
PHST- 2018/11/03 00:00 [received]
PHST- 2019/04/01 00:00 [revised]
PHST- 2019/04/05 00:00 [accepted]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2020/06/26 06:00 [medline]
PHST- 2019/04/25 06:00 [entrez]
AID - S0022-3956(18)31294-9 [pii]
AID - 10.1016/j.jpsychires.2019.04.005 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2019 Jul;114:24-33. doi: 10.1016/j.jpsychires.2019.04.005. Epub 
      2019 Apr 9.