PMID- 31015527
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20231011
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Apr 23
TI  - New Approach in Ulcer Prevention and Wound Healing Treatment using Doxycycline 
      and Amoxicillin/LDH Nanocomposites.
PG  - 6418
LID - 10.1038/s41598-019-42842-2 [doi]
LID - 6418
AB  - Doxycycline (DOX) and amoxicillin (AMOX) are important Broad-spectrum antibiotics 
      used in treating multiple human and animal diseases. For the sake of exploring 
      novel medical applications, both antibiotics were loaded into magnesium aluminium 
      layer double hydroxide (Mg-Al)/LDH nanocomposite through the co-precipitation 
      method. The synthesized materials were characterized by XRD, FT-IR, particle size 
      analysis, FESEM and HRTEM. Acute toxicological studies were conducted using 
      median lethal dose LD(50), where a total number of 98 rats (200-150 gm) of both 
      sexes were used. An experimental wound was aseptically incised on the 
      anterior-dorsal side of each rat, while 98% of pure medical ethanol was used for 
      ulcer induction. Acute toxicity, wound closure rate, healing percentages, ulcer 
      index, protective rate and histopathological studies were investigated. 
      Antibiotic Nanocomposites has significantly prevented ulcer formation and 
      improved wound healing process to take shorter time than that of the typical 
      processes, when compared with that of same drugs in microscale systems or 
      commercial standard drugs. These results were confirmed by the histopathological 
      findings. By converting it into the Nanoform, which is extremely important, 
      especially with commonly used antibiotics, novel pharmacological properties were 
      acquired from the antibiotics. The safe uses of DOX/LDH and AMOX/LDH 
      Nanocomposites in this study were approved for biomedical applications.
FAU - El-Ela, Fatma I Abo
AU  - El-Ela FIA
AD  - Lecturer of Pharmacology, Department of Pharmacology, Faculty of Veterinary 
      Medicine, Beni-Suef University, Beni-Suef, Egypt. fa.pharma@yahoo.com.
FAU - Farghali, Ahmed A
AU  - Farghali AA
AD  - Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies 
      for Sciences, Beni-Suef University, Beni-Suef, Egypt.
FAU - Mahmoud, Rehab K
AU  - Mahmoud RK
AD  - Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef, 
      Egypt.
FAU - Mohamed, Nada A
AU  - Mohamed NA
AD  - Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef, 
      Egypt.
FAU - Moaty, S A Abdel
AU  - Moaty SAA
AD  - Materials Science Lab, Department of Chemistry, Faculty of Science, Beni-Suef 
      University, Beni-Suef, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190423
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Drug Combinations)
RN  - 37317-08-1 (aluminum hydroxide, magnesium hydroxide, drug combination)
RN  - 3K9958V90M (Ethanol)
RN  - 5QB0T2IUN0 (Aluminum Hydroxide)
RN  - 804826J2HU (Amoxicillin)
RN  - N12000U13O (Doxycycline)
RN  - NBZ3QY004S (Magnesium Hydroxide)
SB  - IM
MH  - Aluminum Hydroxide/*chemistry
MH  - Amoxicillin/*pharmacology
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Doxycycline/*pharmacology
MH  - Drug Carriers
MH  - Drug Combinations
MH  - Drug Compounding/methods
MH  - Ethanol/administration & dosage
MH  - Female
MH  - Humans
MH  - Magnesium Hydroxide/*chemistry
MH  - Male
MH  - Nanocomposites/administration & dosage/*chemistry/ultrastructure
MH  - Rats
MH  - Skin Ulcer/chemically induced/pathology/*prevention & control
MH  - Treatment Outcome
MH  - Wound Healing/drug effects/physiology
MH  - Wounds, Nonpenetrating/*drug therapy
PMC - PMC6478882
COIS- The authors declare no competing interests.
EDAT- 2019/04/25 06:00
MHDA- 2020/10/21 06:00
PMCR- 2019/04/23
CRDT- 2019/04/25 06:00
PHST- 2017/11/02 00:00 [received]
PHST- 2019/02/07 00:00 [accepted]
PHST- 2019/04/25 06:00 [entrez]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/04/23 00:00 [pmc-release]
AID - 10.1038/s41598-019-42842-2 [pii]
AID - 42842 [pii]
AID - 10.1038/s41598-019-42842-2 [doi]
PST - epublish
SO  - Sci Rep. 2019 Apr 23;9(1):6418. doi: 10.1038/s41598-019-42842-2.