PMID- 31015750
OWN - NLM
STAT- MEDLINE
DCOM- 20191125
LR  - 20191125
IS  - 0386-300X (Print)
IS  - 0386-300X (Linking)
VI  - 73
IP  - 2
DP  - 2019 Apr
TI  - Clinical Characteristics of Severe Refractory Asthma Associated with the 
      Effectiveness of Bronchial Thermoplasty.
PG  - 155-160
LID - 10.18926/AMO/56651 [doi]
AB  - We investigated the clinical characteristics of refractory asthma associated with 
      the effectiveness of bronchial thermoplasty (BT). We retrospectively evaluated 
      data from 10 patients who underwent BT between June 2016 and December 2017 at 
      Okayama Medical Center. The following were measured before and 6 months post-BT: 
      forced expiratory volume in 1.0 s (FEV1), fractional exhaled nitric oxide (FeNO), 
      immunoglobulin E (IgE) level, blood eosinophil counts (Eosi), Asthma Quality of 
      Life Questionnaire (AQLQ) score, and preventive medication use. At baseline, the 
      mean post-bronchodilator FEV1 was 80.9% of the predicted value (range 
      45.6-115.7%). All patients were being treated with moderate- or high-dose inhaled 
      corticosteroids and long-acting beta2 agonists. The AQLQ improved from 4.26+/-1.67 at 
      baseline to 5.59+/-0.94 at 6 months post-BT (p<0.05). The %FEV1, FeNO, IgE, and 
      Eosi did not change significantly between baseline and 6 months post-BT. No 
      severe complications were reported. BT was effective for non-allergic and 
      non-eosinophilic in 3 patients, and allergic or eosinophilic in 4 patients. Their 
      AQLQ improved by > 0.5 points post-BT. For both allergic and eosinophilic 
      asthmatics following mepolizumab, BT was not useful. BT was effective for 
      non-allergic and non-eosinophilic or allergic asthmatics, but insufficient for 
      both allergic and eosinophilic following mepolizumab.
FAU - Minami, Daisuke
AU  - Minami D
AD  - Department of Respiratory Medicine, Okayama Medical Center, Okayama 701-1192, 
      Japan.d-minami@bj8.so-net.ne.jp.
FAU - Kayatani, Hiroe
AU  - Kayatani H
FAU - Sato, Ken
AU  - Sato K
FAU - Fujiwara, Keiichi
AU  - Fujiwara K
FAU - Shibayama, Takuo
AU  - Shibayama T
FAU - Yonei, Toshiro
AU  - Yonei T
FAU - Sato, Toshio
AU  - Sato T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Acta Med Okayama
JT  - Acta medica Okayama
JID - 0417611
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 90Z2UF0E52 (mepolizumab)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal, Humanized/therapeutic use
MH  - Asthma/physiopathology/*therapy
MH  - Bronchial Thermoplasty/*methods
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
OTO - NOTNLM
OT  - non-eosinophilic asthma
OT  - airway hyper-responsiveness
OT  - bronchial thermoplasty
OT  - non-allergic asthma
OT  - patient selection
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2019/04/25 06:00
MHDA- 2019/11/26 06:00
CRDT- 2019/04/25 06:00
PHST- 2019/04/25 06:00 [entrez]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2019/11/26 06:00 [medline]
AID - 10.18926/AMO/56651 [doi]
PST - ppublish
SO  - Acta Med Okayama. 2019 Apr;73(2):155-160. doi: 10.18926/AMO/56651.