PMID- 31015797
OWN - NLM
STAT- MEDLINE
DCOM- 20190826
LR  - 20220409
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2019
DP  - 2019
TI  - Association between Irisin, hs-CRP, and Metabolic Status in Children and 
      Adolescents with Type 2 Diabetes Mellitus.
PG  - 6737318
LID - 10.1155/2019/6737318 [doi]
LID - 6737318
AB  - Proinflammatory cytokines and the novel myokine irisin, a cleavage product of 
      FNDC5, have been found to play a role in obesity and type 2 diabetes mellitus 
      (T2DM). Irisin has been shown to increase browning of adipose tissue, 
      thermogenesis, energy expenditure, and insulin sensitivity, yet its association 
      with inflammatory markers is still limited. Circulating irisin has been found to 
      be increased in obesity, while in adult subjects with T2DM decreased levels have 
      been found. However, data establishing the association of circulating irisin in 
      children and adolescents with T2DM has not been described in the literature. The 
      objective of this study was to determine irisin plasma concentration and its 
      association with metabolic and adiposity markers and with hs-CRP, a surrogate 
      marker of inflammation used in clinical practice, in a pediatric population with 
      T2DM. A cross-sample of 40 Mexican children and adolescents aged 7-17 were 
      recruited, 20 diagnosed with T2DM and 20 healthy controls. Plasma irisin levels 
      were found to be lower in the T2DM group compared with controls, which could be 
      attributed to a reduced PGC-1alpha activity in muscle tissue with a consequent 
      decrease in FNDC5 and irisin expression. Irisin concentration was found to be 
      positively correlated with HDL-c, LDL-c, and total cholesterol, while negatively 
      correlated with BMI, waist circumference, and triglycerides. However, after 
      multiple regression analysis, only HDL-c correlation remained significant. hs-CRP 
      was higher in the T2DM group and positively associated with adiposity markers, 
      unfavorable lipid profile, insulin levels, and HOMA-IR, but no association with 
      irisin was found. Given the favorable metabolic effects attributed to irisin, the 
      low plasma levels found in children and adolescents with T2DM could exacerbate 
      the inflammatory and metabolic imbalances and the intrinsic cardiovascular risk 
      of this disease. We propose an "irisin-proinflammatory/anti-inflammatory axis" to 
      explain the role of irisin as a metabolic regulator in obesity and T2DM.
FAU - Elizondo-Montemayor, Leticia
AU  - Elizondo-Montemayor L
AUID- ORCID: 0000-0002-2076-1769
AD  - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. 
      Morones Prieto 3000, Monterrey, N.L. 64710, Mexico.
AD  - Tecnologico de Monterrey, Center for Research in Clinical Nutrition and Obesity, 
      Ave. Morones Prieto 300, Monterrey, N.L. 64710, Mexico.
AD  - Tecnologico de Monterrey, Cardiovascular and Metabolomics Research Group, 
      Hospital Zambrano Hellion, San Pedro Garza Garcia, P.C. 66278, Mexico.
FAU - Gonzalez-Gil, Adrian M
AU  - Gonzalez-Gil AM
AUID- ORCID: 0000-0002-3379-1916
AD  - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. 
      Morones Prieto 3000, Monterrey, N.L. 64710, Mexico.
AD  - Tecnologico de Monterrey, Center for Research in Clinical Nutrition and Obesity, 
      Ave. Morones Prieto 300, Monterrey, N.L. 64710, Mexico.
FAU - Tamez-Rivera, Oscar
AU  - Tamez-Rivera O
AUID- ORCID: 0000-0002-1199-7884
AD  - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. 
      Morones Prieto 3000, Monterrey, N.L. 64710, Mexico.
AD  - Tecnologico de Monterrey, Center for Research in Clinical Nutrition and Obesity, 
      Ave. Morones Prieto 300, Monterrey, N.L. 64710, Mexico.
FAU - Toledo-Salinas, Carla
AU  - Toledo-Salinas C
AUID- ORCID: 0000-0002-9354-2479
AD  - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. 
      Morones Prieto 3000, Monterrey, N.L. 64710, Mexico.
AD  - Tecnologico de Monterrey, Center for Research in Clinical Nutrition and Obesity, 
      Ave. Morones Prieto 300, Monterrey, N.L. 64710, Mexico.
FAU - Peschard-Franco, Mariana
AU  - Peschard-Franco M
AUID- ORCID: 0000-0003-1133-4877
AD  - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. 
      Morones Prieto 3000, Monterrey, N.L. 64710, Mexico.
AD  - Tecnologico de Monterrey, Center for Research in Clinical Nutrition and Obesity, 
      Ave. Morones Prieto 300, Monterrey, N.L. 64710, Mexico.
FAU - Rodriguez-Gutierrez, Nora A
AU  - Rodriguez-Gutierrez NA
AUID- ORCID: 0000-0003-1972-0625
AD  - Hospital Regional de Alta Especialidad Materno Infantil, Ave. San Rafael 450, 
      Guadalupe, P.C. 67140, Mexico.
FAU - Silva-Platas, Christian
AU  - Silva-Platas C
AUID- ORCID: 0000-0003-3760-8733
AD  - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. 
      Morones Prieto 3000, Monterrey, N.L. 64710, Mexico.
AD  - Tecnologico de Monterrey, Cardiovascular and Metabolomics Research Group, 
      Hospital Zambrano Hellion, San Pedro Garza Garcia, P.C. 66278, Mexico.
FAU - Garcia-Rivas, Gerardo
AU  - Garcia-Rivas G
AUID- ORCID: 0000-0003-4731-3293
AD  - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. 
      Morones Prieto 3000, Monterrey, N.L. 64710, Mexico.
AD  - Tecnologico de Monterrey, Cardiovascular and Metabolomics Research Group, 
      Hospital Zambrano Hellion, San Pedro Garza Garcia, P.C. 66278, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20190320
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Triglycerides)
RN  - 9007-41-4 (C-Reactive Protein)
MH  - Adolescent
MH  - Anthropometry
MH  - Body Mass Index
MH  - C-Reactive Protein/*metabolism
MH  - Child
MH  - Diabetes Mellitus, Type 2/*blood/*metabolism
MH  - Female
MH  - Fibronectins/*blood
MH  - Humans
MH  - Male
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/blood
MH  - Triglycerides/blood
MH  - Waist Circumference
PMC - PMC6446111
EDAT- 2019/04/25 06:00
MHDA- 2019/08/27 06:00
PMCR- 2019/03/20
CRDT- 2019/04/25 06:00
PHST- 2018/12/07 00:00 [received]
PHST- 2019/01/28 00:00 [revised]
PHST- 2019/02/07 00:00 [accepted]
PHST- 2019/04/25 06:00 [entrez]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2019/08/27 06:00 [medline]
PHST- 2019/03/20 00:00 [pmc-release]
AID - 10.1155/2019/6737318 [doi]
PST - epublish
SO  - Mediators Inflamm. 2019 Mar 20;2019:6737318. doi: 10.1155/2019/6737318. 
      eCollection 2019.