PMID- 31016150
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 23
IP  - 1
DP  - 2019 Jan-Feb
TI  - Evaluation of Vitamin D Status and its Impact on Thyroid Related Parameters in 
      New Onset Graves' Disease- A Cross-sectional Observational Study.
PG  - 35-39
LID - 10.4103/ijem.IJEM_183_18 [doi]
AB  - AIMS AND OBJECTIVE: We aimed to compare serum vitamin D level in new onset 
      Graves' disease versus age and sex matched controls. Furthermore, we assessed the 
      correlation of vitamin D with hormonal parameters and antibody titers in Graves' 
      disease. MATERIALS AND METHODS: In total, 84 patients of new onset Graves' 
      disease and 42 age and sex matched healthy individuals were recruited. 
      Biochemical and hormonal investigations that included serum calcium, phosphorous, 
      free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone 
      (TSH), 25 hydroxy vitamin D (25(OH) D), and parathyroid hormone (PTH) were done 
      for all subjects. Thyrotropin receptor antibody (TRAb) was measured only for 
      Graves' disease patients. RESULTS: The patients with Graves' disease had 
      significantly lower 25(OH) D levels (19.2 +/- 8.9 ng/ml) as compared to control 
      subjects (23.8 +/- 12.5 ng/ml) (P = 0.019). Thyroid hormone levels, thyroid volume, 
      and TRAb titers did not differ significantly between vitamin D deficient Graves' 
      disease group (25(OH)D <20 ng/ml) and vitamin D non deficient Graves' disease 
      group (25(OH)D >/=20 ng/ml). Furthermore, serum vitamin D level did not correlate 
      significantly with thyroid hormones, thyroid volume, or TRAb titers among Graves' 
      disease. The odds ratio (OR) for association of vitamin D deficiency (VDD) state 
      and Graves' disease was 1.62 (95% CI 0.77-3.41). Vitamin D sufficiency state was 
      associated significantly with lower risk of Graves' disease (OR = 0.38, 95% CI 
      0.15-0.95). CONCLUSION: Serum vitamin D levels are significantly lower in new 
      onset Graves' disease. No significant correlation between vitamin D and thyroid 
      hormones, thyroid volume, or TRAb titers was found in these patients. VDD state 
      is not associated with Graves' disease.
FAU - Mangaraj, Swayamsidha
AU  - Mangaraj S
AD  - Department of Endocrinology, S.C.B Medical College, Cuttack, Odisha, India.
FAU - Choudhury, Arun K
AU  - Choudhury AK
AD  - Department of Endocrinology, S.C.B Medical College, Cuttack, Odisha, India.
FAU - Swain, Basanta M
AU  - Swain BM
AD  - Department of Radiology, S.C.B Medical College, Cuttack, Odisha, India.
FAU - Sarangi, Pradosh K
AU  - Sarangi PK
AD  - Department of Radiology, S.C.B Medical College, Cuttack, Odisha, India.
FAU - Mohanty, Binoy K
AU  - Mohanty BK
AD  - Department of Endocrinology, M.K.C.G Medical College, Berhampur, Odisha, India.
FAU - Baliarsinha, Anoj K
AU  - Baliarsinha AK
AD  - Department of Endocrinology, S.C.B Medical College, Cuttack, Odisha, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC6446662
OTO - NOTNLM
OT  - Autoimmune thyroid disease
OT  - Graves' disease
OT  - thyroid
OT  - vitamin D
COIS- There are no conflicts of interest.
EDAT- 2019/04/25 06:00
MHDA- 2019/04/25 06:01
PMCR- 2019/01/01
CRDT- 2019/04/25 06:00
PHST- 2019/04/25 06:00 [entrez]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2019/04/25 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - IJEM-23-35 [pii]
AID - 10.4103/ijem.IJEM_183_18 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2019 Jan-Feb;23(1):35-39. doi: 
      10.4103/ijem.IJEM_183_18.