PMID- 31016286
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231006
IS  - 2576-2095 (Electronic)
IS  - 2096-5451 (Print)
IS  - 2576-2095 (Linking)
VI  - 2
IP  - 1
DP  - 2019 Mar
TI  - Comparison of gene expression in cynomolgus monkeys with preclinical type II 
      diabetes induced by different high energy diets.
PG  - 44-50
LID - 10.1002/ame2.12058 [doi]
AB  - BACKGROUND: Cynomolgus disease models that are similar to the preclinical stage 
      of human type 2 diabetes mellitus (T2DM) were established by feeding middle-aged 
      cynomolgus monkeys different high energy diets to study the differential 
      expression of diabetes-related genes. METHODS: A total of 36 male monkeys were 
      randomly divided into four groups and fed human diets with high sugar, high fat, 
      double high sugar and fat, and a normal diet. The preclinical diabetes phase was 
      determined by monitoring the metabolic characteristic indices and the results of 
      oral glucose tolerance tests (OGTT). The mRNA expression of 45 diabetes-related 
      genes in peripheral blood leukocytes was analyzed using real-time PCR. RESULTS: A 
      total of 22, 25, and 21 genes were significantly up-regulated (P < 0.05) and 5, 
      7, and 5 genes were significantly down-regulated (P < 0.05) in the above three 
      induced groups, respectively, compared with the control group. Of the 45 tested 
      genes, the expression profiles of 21 genes were consistent. Most of the 
      expression levels in the double high sugar-and-fat individuals were slightly 
      lower than those in the high glucose and high fat groups, although the expression 
      patterns of the three groups were essentially similar. CONCLUSION: The different 
      high energy diets all induced diabetes and shared some phenotypic properties with 
      human T2DM. Most of the expression patterns of the related genes were identical. 
      The gene expression profiles could be used as references for the study of early 
      diagnostic indicators and T2DM pathogenesis.
FAU - Jin, Li-Sha
AU  - Jin LS
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
AD  - South China Botanical Garden Guangzhou China.
FAU - Rao, Jun-Hua
AU  - Rao JH
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
FAU - Zhang, Li-Biao
AU  - Zhang LB
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
FAU - Ji, Fang
AU  - Ji F
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
FAU - Zhang, Yan-Chun
AU  - Zhang YC
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
FAU - Hao, Xiang-Fen
AU  - Hao XF
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
AD  - South China Botanical Garden Guangzhou China.
FAU - Peng, Bai-Lu
AU  - Peng BL
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
FAU - Liu, Xiao-Ming
AU  - Liu XM
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
FAU - Sun, Yun-Xiao
AU  - Sun YX
AUID- ORCID: 0000-0001-7846-4743
AD  - Guangdong Key Laboratory of Animal Conservation and Resource Utilization 
      Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong 
      Institute of Applied Biological Resources Guangzhou China.
LA  - eng
PT  - Journal Article
DEP - 20190220
PL  - United States
TA  - Animal Model Exp Med
JT  - Animal models and experimental medicine
JID - 101726292
PMC - PMC6431119
OTO - NOTNLM
OT  - cynomolgus monkey
OT  - gene expression
OT  - high energy diet
OT  - preclinical phase
OT  - type 2 diabetes
COIS- None.
EDAT- 2019/04/25 06:00
MHDA- 2019/04/25 06:01
PMCR- 2019/02/20
CRDT- 2019/04/25 06:00
PHST- 2018/06/19 00:00 [received]
PHST- 2019/01/18 00:00 [accepted]
PHST- 2019/04/25 06:00 [entrez]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2019/04/25 06:01 [medline]
PHST- 2019/02/20 00:00 [pmc-release]
AID - AME212058 [pii]
AID - 10.1002/ame2.12058 [doi]
PST - epublish
SO  - Animal Model Exp Med. 2019 Feb 20;2(1):44-50. doi: 10.1002/ame2.12058. 
      eCollection 2019 Mar.