PMID- 31016688
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20231213
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Linking)
VI  - 36
IP  - 3
DP  - 2019 Oct
TI  - Anti-inflammatory Activity of Ursolic Acid in MPTP-Induced Parkinsonian Mouse 
      Model.
PG  - 452-462
LID - 10.1007/s12640-019-00038-6 [doi]
AB  - Neuroinflammation plays an important role in the progression of Parkinson's 
      disease (PD) and hence may represent a target for treatment. The drugs used 
      currently for PD only provide symptomatic relief and have adverse effects in 
      addition to their inability in preventing degeneration of neurons. Flavonoids 
      show potent antioxidant and anti-inflammatory activities which is very valuable 
      for the health of human beings. Thus, in the present study, we have tried to 
      explore the anti-inflammatory activity of orally given ursolic acid (UA) 
      (25 mg/kg bwt), a pentacyclic triterpenoid in 
      1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mouse model. 
      Significant severe oxidative stress and biochemical alterations have been seen in 
      Parkinsonian mice after MPTP intoxication. Whereas, UA administration has 
      significantly rescued the harmful consequence of MPTP intoxication. Ionized 
      calcium-binding adaptor molecule 1 (Iba1), tumor necrosis factor-alpha (TNF-alpha), 
      and nuclear transcription factor-kappaB (NF-kappaB) were seen to be altered in the 
      substantia nigra pars compacta (SNpc) of MPTP-intoxicated mice through 
      immunohistochemical studies. The changes in the expression level of these 
      parameters primarily suggest increased inflammatory responses in MPTP-intoxicated 
      mice as compared with the control. However, UA have significantly reduced these 
      inflammatory parameters (Iba1 and TNF-alpha) along with transcription factor NF-kappaB, 
      which regulates these inflammatory parameters and thus have inhibited 
      MPTP-induced neuroinflammation. The immunoreactivity of tyrosine hydroxylase (TH) 
      was considerably increased by UA treatment in the SNpc of Parkinsonian mice. The 
      neuroinflammation and neurodegeneration along with impairments in biochemical and 
      behavioral parameters were found to be reversed on treatment with UA. Thus, UA 
      has shown potent anti-inflammatory activity by preventing the degeneration of 
      dopaminergic neurons from MPTP-induced Parkinsonian mice.
FAU - Rai, Sachchida Nand
AU  - Rai SN
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Zahra, Walia
AU  - Zahra W
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Singh, Saumitra Sen
AU  - Singh SS
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Birla, Hareram
AU  - Birla H
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Keswani, Chetan
AU  - Keswani C
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Dilnashin, Hagera
AU  - Dilnashin H
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Rathore, Aaina Singh
AU  - Rathore AS
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Singh, Rajan
AU  - Singh R
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Singh, Rakesh K
AU  - Singh RK
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India.
FAU - Singh, Surya Pratap
AU  - Singh SP
AD  - Department of Biochemistry, Institute of Science, Banaras Hindu University, 
      Varanasi, 221005, India. suryasinghbhu16@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190423
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antiparkinson Agents)
RN  - 0 (Nitrites)
RN  - 0 (Triterpenes)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
RN  - EC 1.11.1.6 (Catalase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Antiparkinson Agents/*therapeutic use
MH  - Brain/drug effects/metabolism
MH  - Catalase/metabolism
MH  - Fluorescent Antibody Technique
MH  - Glutathione/metabolism
MH  - Inflammation/drug therapy
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Mice
MH  - Nitrites/metabolism
MH  - Parkinsonian Disorders/chemically induced/*drug therapy
MH  - Psychomotor Performance
MH  - Real-Time Polymerase Chain Reaction
MH  - Rotarod Performance Test
MH  - Triterpenes/*therapeutic use
MH  - Ursolic Acid
OTO - NOTNLM
OT  - MPTP
OT  - Neuroinflammation
OT  - Parkinson's disease
OT  - Ursolic acid
EDAT- 2019/04/25 06:00
MHDA- 2020/02/11 06:00
CRDT- 2019/04/25 06:00
PHST- 2019/01/19 00:00 [received]
PHST- 2019/03/29 00:00 [accepted]
PHST- 2019/03/26 00:00 [revised]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/04/25 06:00 [entrez]
AID - 10.1007/s12640-019-00038-6 [pii]
AID - 10.1007/s12640-019-00038-6 [doi]
PST - ppublish
SO  - Neurotox Res. 2019 Oct;36(3):452-462. doi: 10.1007/s12640-019-00038-6. Epub 2019 
      Apr 23.