PMID- 31016876
OWN - NLM
STAT- MEDLINE
DCOM- 20210809
LR  - 20210809
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Print)
IS  - 1552-4973 (Linking)
VI  - 108
IP  - 2
DP  - 2020 Feb
TI  - Nanofibrous antibiotic-eluting matrices: Biocompatibility studies in a rat model.
PG  - 306-315
LID - 10.1002/jbm.b.34389 [doi]
AB  - This study evaluated the biocompatibility of degradable polydioxanone (PDS) 
      electrospun drug delivery systems (hereafter referred as matrices) containing 
      metronidazole (MET) or ciprofloxacin (CIP) after subcutaneous implantation in 
      rats. Sixty adult male rats were randomized into six groups: SHAM (sham surgery); 
      PDS (antibiotic-free matrix); 1MET (one 25 wt% MET matrix); 1CIP (one 25 wt% CIP 
      matrix); 2MET (two 25 wt% MET matrices); and 2CIP (two 25 wt% CIP matrices). At 3 
      and 30 days, animals were assessed for inflammatory cell response (ICR), collagen 
      fibers degradation, and oxidative profile (reactive oxygen species [ROS]; lipid 
      peroxidation [LP]; and protein carbonyl [PC]). At 3 days, percentages of 
      no/discrete ICR were 100, 93.3, 86.7, 76.7, 50, and 66.6 for SHAM, PDS, 1MET, 
      1CIP, 2MET, and 2CIP, respectively. At 30 days, percentages of no/discrete ICR 
      were 100% for SHAM, PDS, 1MET, and 1CIP and 93.3% for 2MET and 2CIP. Between 3 
      and 30 days, SHAM, 1CIP, and 2CIP produced collagen, while 1MET and 2MET were 
      unchanged. At 30 days, the collagen fiber means percentages for SHAM, PDS, 1MET, 
      1CIP, 2MET, and 2CIP were 63.7, 60.7, 56.6, 62.6, 51.8, and 61.7, respectively. 
      Antibiotic-eluting matrices showed similar or better oxidative behavior when 
      compared to PDS, except for CIP-eluting matrices, which showed higher levels of 
      PC compared to SHAM or PDS at 30 days. Collectively, our findings indicate that 
      antibiotic-eluting matrices may be an attractive biocompatible drug delivery 
      system to fight periodontopathogens. (c) 2019 Wiley Periodicals, Inc. J Biomed 
      Mater Res Part B, 2019.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Passos, Patricia C
AU  - Passos PC
AD  - Post-Graduate Program in Oral Science (Periodontology Unit), School of Dentistry, 
      Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
FAU - Moro, Juliana
AU  - Moro J
AD  - Post-Graduate Program in Oral Science (Pathology Unit), School of Dentistry, 
      Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
FAU - Barcelos, Raquel Cristine Silva
AU  - Barcelos RCS
AD  - Post-Graduate Program in Oral Science (Pathology Unit), School of Dentistry, 
      Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
FAU - Da Rosa, Higor Z
AU  - Da Rosa HZ
AD  - Post-Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM), 
      Santa Maria, Rio Grande do Sul, Brazil.
FAU - Vey, Luciana T
AU  - Vey LT
AD  - Post-Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM), 
      Santa Maria, Rio Grande do Sul, Brazil.
FAU - Burguer, Marilise Escobar
AU  - Burguer ME
AD  - Post-Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM), 
      Santa Maria, Rio Grande do Sul, Brazil.
FAU - Maciel, Roberto M
AU  - Maciel RM
AD  - Post-Graduate Program in Oral Science (Pathology Unit), School of Dentistry, 
      Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
FAU - Danesi, Cristiane C
AU  - Danesi CC
AD  - Post-Graduate Program in Oral Science (Pathology Unit), School of Dentistry, 
      Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
FAU - Edwards, Paul C
AU  - Edwards PC
AD  - Department of Oral Pathology, Medicine and Radiology, Indiana University School 
      of Dentistry, Indianapolis, Indiana.
FAU - Bottino, Marco C
AU  - Bottino MC
AUID- ORCID: 0000-0001-8740-2464
AD  - Department of Cariology, Restorative Sciences, and Endodontics, University of 
      Michigan School of Dentistry, Ann Arbor, Michigan.
FAU - Kantorski, Karla Z
AU  - Kantorski KZ
AD  - Post-Graduate Program in Oral Science (Periodontology Unit), School of Dentistry, 
      Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
LA  - eng
GR  - K08 DE023552/DE/NIDCR NIH HHS/United States
GR  - R01 DE026578/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190423
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Nanocapsules)
RN  - 0 (Reactive Oxygen Species)
RN  - 140QMO216E (Metronidazole)
RN  - 31621-87-1 (Polydioxanone)
RN  - 5E8K9I0O4U (Ciprofloxacin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*chemistry/pharmacology
MH  - Biocompatible Materials/*chemistry
MH  - Ciprofloxacin/*chemistry/pharmacology
MH  - Drug Liberation
MH  - Humans
MH  - Male
MH  - Metronidazole/*chemistry/pharmacology
MH  - Nanocapsules/*chemistry
MH  - Nanofibers/*chemistry
MH  - Oxidation-Reduction
MH  - Polydioxanone/*chemistry
MH  - Prosthesis Implantation
MH  - Rats
MH  - Reactive Oxygen Species/metabolism
MH  - Time Factors
MH  - Tissue Engineering
MH  - Tissue Scaffolds
PMC - PMC6812584
MID - NIHMS1024282
OTO - NOTNLM
OT  - biomaterials
OT  - drug delivery
OT  - electrospinning
OT  - nanofibers
OT  - periodontitis
EDAT- 2019/04/25 06:00
MHDA- 2021/08/10 06:00
PMCR- 2021/02/01
CRDT- 2019/04/25 06:00
PHST- 2019/01/03 00:00 [received]
PHST- 2019/03/18 00:00 [revised]
PHST- 2019/04/04 00:00 [accepted]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2021/08/10 06:00 [medline]
PHST- 2019/04/25 06:00 [entrez]
PHST- 2021/02/01 00:00 [pmc-release]
AID - 10.1002/jbm.b.34389 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2020 Feb;108(2):306-315. doi: 
      10.1002/jbm.b.34389. Epub 2019 Apr 23.