PMID- 31016907
OWN - NLM
STAT- MEDLINE
DCOM- 20190617
LR  - 20200225
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 60
IP  - 5
DP  - 2019 May
TI  - Comparison of Radiological and Histological Findings of Lung Parenchyma in 
      Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
PG  - 454-460
LID - 10.3349/ymj.2019.60.5.454 [doi]
AB  - PURPOSE: The present study investigated chest computed tomography (CT) patterns 
      and lung histological features, as well as the consistency between radiological 
      and histological features among patients with microscopic polyangiitis (MPA), 
      granulomatosis with polyangiitis (GPA), and eosinophilic GPA (EGPA). MATERIALS 
      AND METHODS: The medical records of 74 antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV) patients with radiological lung parenchymal 
      lesions were reviewed along with the histological results for 28 of them. Chest 
      CT patterns were divided according 12 items mostly suggested by radiologists and 
      histological features were divided according to necrotising granuloma, 
      necrotising vasculitis, eosinophilic infiltration, and hemosiderin laden 
      macrophages as defined by a pathologist. RESULTS: The mean age was 57.1 years (22 
      men). The most common clinical manifestation other than lung manifestation was 
      renal manifestation (62.2%), and the most common chest CT pattern was lung 
      involvement of vasculitis (35.1%). In MPA patients, the major histological 
      features were hemosiderin-laden macrophages in the alveolar space and vasculitis. 
      In GPA patients, the major histological features were necrotizing vasculitis and 
      necrotizing granuloma, while in EGPA patients, the major histological feature was 
      only necrotising vasculitis. The consistency rate in GPA patients was the highest 
      (100%), followed by that in MPA patients (66.7%) and EGPA patients (50.0%). 
      CONCLUSION: When lung involvement of AAV is suspected on chest CT, lung biopsy 
      should be recommended for the proper classification of AAV, due to the 
      discordance rate between radiological and histological findings in MPA and EGPA 
      patients, but not GPA patients.
CI  - (c) Copyright: Yonsei University College of Medicine 2019.
FAU - Park, Hee Jin
AU  - Park HJ
AUID- ORCID: 0000-0002-6324-5262
AD  - Division of Rheumatology, Department of Internal Medicine, Catholic Kwandong 
      University College of Medicine, International St. Mary's Hospital, Incheon, 
      Korea.
FAU - Jung, Seung Min
AU  - Jung SM
AUID- ORCID: 0000-0003-3465-2181
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Song, Jason Jungsik
AU  - Song JJ
AUID- ORCID: 0000-0003-0662-7704
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Park, Yong Beom
AU  - Park YB
AUID- ORCID: 0000-0003-4695-8620
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Song, Ji Sun
AU  - Song JS
AUID- ORCID: 0000-0003-4877-3128
AD  - Department of Pathology, Catholic Kwandong University College of Medicine, 
      International St. Mary's Hospital, Incheon, Korea. jsong@ish.ac.kr.
FAU - Lee, Sang Won
AU  - Lee SW
AUID- ORCID: 0000-0002-8038-3341
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea. sangwonlee@yuhs.ac.
LA  - eng
GR  - 6-2016-0145/YUCM/Yonsei University College of Medicine/Korea
PT  - Comparative Study
PT  - Journal Article
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adult
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis/*diagnostic 
      imaging/*pathology
MH  - Antibodies, Antineutrophil Cytoplasmic/immunology
MH  - Female
MH  - Humans
MH  - Lung/*diagnostic imaging/*pathology
MH  - Male
MH  - Tomography, X-Ray Computed
PMC - PMC6479123
OTO - NOTNLM
OT  - EGPA
OT  - GPA
OT  - MPA
OT  - chest CT
OT  - histology
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2019/04/25 06:00
MHDA- 2019/06/18 06:00
PMCR- 2019/05/01
CRDT- 2019/04/25 06:00
PHST- 2018/12/31 00:00 [received]
PHST- 2019/02/28 00:00 [revised]
PHST- 2019/03/05 00:00 [accepted]
PHST- 2019/04/25 06:00 [entrez]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2019/06/18 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - 60.454 [pii]
AID - 10.3349/ymj.2019.60.5.454 [doi]
PST - ppublish
SO  - Yonsei Med J. 2019 May;60(5):454-460. doi: 10.3349/ymj.2019.60.5.454.