PMID- 31017555
OWN - NLM
STAT- MEDLINE
DCOM- 20200228
LR  - 20200228
IS  - 0300-9831 (Print)
IS  - 0300-9831 (Linking)
VI  - 90
IP  - 1-2
DP  - 2020 Jan
TI  - Neuroprotective and long term potentiation improving effects of vitamin E in 
      juvenile hypothyroid rats.
PG  - 156-168
LID - 10.1024/0300-9831/a000533 [doi]
AB  - Protective effects of vitamin E (Vit E) on long term potentiation (LTP) 
      impairment, neuronal apoptosis and increase of nitric oxide (NO) metabolites in 
      the hippocampus of juvenile rats were examined. The rats were grouped (n=13) as: 
      (1) control; (2) hypothyroid (Hypo) and (3) Hypo-Vit E. Propylthiouracil (PTU) 
      was given in drinking water (0.05%) during 6 weeks. Vit E (20 mg/ kg) was daily 
      injected (IP). To evaluate synaptic plasticity, LTP from the CA(1) area of the 
      hippocampus followed by high frequency stimulation to the ipsilateral Schafer 
      collateral pathway was carried out. The cortical and hippocampal tissues were 
      then removed to measure NO metabolites. The brains of 5 animals in each group 
      were removed for apoptosis study. The hypothyroidism status decreased the slope, 
      10-90% slope and amplitude of field excitatory post synaptic potential (fEPSP) 
      compared to the control group (P<0.01-P<0.001). Injection of Vit E increased the 
      slope, 10-90% slope and amplitude of the fEPSP in the Hypo-Vit E group in 
      comparison to the Hypo group (P<0.05-P<0.01). TUNEL positive neurons and NO 
      metabolites were higher in the hippocampus of the Hypo rats, as compared to those 
      in the hippocampus of the control ones (P<0.001). Treatment of the Hypo rats by 
      Vit E decreased apoptotic neurons (P<0.01-P<0.001) and NO metabolites (P<0.001) 
      in the hippocampus compared to the Hypo rats. The results of the present study 
      showed that Vit E prevented the LTP impairment and neuronal apoptosis in the 
      hippocampus of juvenile hypothyroid rats.
FAU - Baghcheghi, Yousef
AU  - Baghcheghi Y
AD  - Student Research Committee, Department of Physiology, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Mansouri, Somaieh
AU  - Mansouri S
AD  - Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University 
      of Medical Sciences, Mashhad, Iran.
FAU - Beheshti, Farimah
AU  - Beheshti F
AD  - Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, 
      Torbat Heydariyeh, Iran.
AD  - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research 
      Center, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Shafei, Mohammad Naser
AU  - Shafei MN
AD  - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research 
      Center, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Salmani, Hossien
AU  - Salmani H
AD  - Student Research Committee, Department of Physiology, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Reisi, Parham
AU  - Reisi P
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Anaeigoudari, Akbar
AU  - Anaeigoudari A
AD  - Department of Physiology, School of Medicine, Jiroft University of Medical 
      Sciences, Jiroft, Iran.
FAU - Bideskan, Alireza Ebrahimzadeh
AU  - Bideskan AE
AD  - Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Hosseini, Mahmoud
AU  - Hosseini M
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190424
PL  - Switzerland
TA  - Int J Vitam Nutr Res
JT  - International journal for vitamin and nutrition research. Internationale 
      Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de 
      vitaminologie et de nutrition
JID - 1273304
RN  - 1406-18-4 (Vitamin E)
SB  - IM
MH  - Animals
MH  - Hippocampus/*drug effects
MH  - *Hypothyroidism/drug therapy
MH  - *Long-Term Potentiation
MH  - Rats
MH  - Rats, Wistar
MH  - Vitamin E/chemistry/*pharmacology
OTO - NOTNLM
OT  - Apoptosis
OT  - Hippocampus Vitamin E
OT  - Hypothyroidism
OT  - Long term potentiation
OT  - Nitric oxide
EDAT- 2019/04/25 06:00
MHDA- 2020/02/29 06:00
CRDT- 2019/04/25 06:00
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2020/02/29 06:00 [medline]
PHST- 2019/04/25 06:00 [entrez]
AID - 10.1024/0300-9831/a000533 [doi]
PST - ppublish
SO  - Int J Vitam Nutr Res. 2020 Jan;90(1-2):156-168. doi: 10.1024/0300-9831/a000533. 
      Epub 2019 Apr 24.