PMID- 31018025
OWN - NLM
STAT- MEDLINE
DCOM- 20201021
LR  - 20201021
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 32
IP  - 3
DP  - 2020 Jan
TI  - Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides.
PG  - e1805798
LID - 10.1002/adma.201805798 [doi]
AB  - Self-assembly is a powerful tool for constructing supramolecular materials for 
      many applications, ranging from energy harvesting to biomedicine. Among the 
      methods to prepare supramolecular materials for biomedical applications, 
      enzyme-instructed self-assembly (EISA) has several advantages. Herein, the unique 
      properties and advantages of EISA in preparing biofunctional supramolecular 
      nanomaterials and hydrogels from peptides are highlighted. EISA can trigger 
      molecular self-assembly in situ. Therefore, using overexpression enzymes in 
      disease sites, supramolecular materials can be formed in situ to improve the 
      selectivity and efficacy of the treatment. The precursor may be involved during 
      the EISA process, and it is actually a two-component self-assembly process. The 
      precursor can help to stabilize the assembled nanostructures of hydrophobic 
      peptides formed by EISA. More importantly, the precursor may determine the 
      outcome of molecular self-assembly. Recently, it was also observed that EISA can 
      kinetically control the peptide folding and morphology and cellular uptake 
      behavior of supramolecular nanomaterials. With the combination of other methods 
      to trigger molecular self-assembly, researchers can form supramolecular 
      nanomaterials in a more precise mode and sometimes under spatiotemporal control. 
      EISA is a powerful and unique methodology to prepare supramolecular biofunctional 
      materials that cannot be generated from other common methods.
CI  - (c) 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Gao, Jie
AU  - Gao J
AD  - Key Laboratory of Bioactive Materials, Ministry of Education, College of Life 
      Sciences, State Key Laboratory of Medicinal Chemical Biology, National Institute 
      for Advanced Materials, and Collaborative Innovation Center of Chemical Science 
      and Engineering, Nankai University, Tianjin, 300071, P. R. China.
FAU - Zhan, Jie
AU  - Zhan J
AD  - Key Laboratory of Bioactive Materials, Ministry of Education, College of Life 
      Sciences, State Key Laboratory of Medicinal Chemical Biology, National Institute 
      for Advanced Materials, and Collaborative Innovation Center of Chemical Science 
      and Engineering, Nankai University, Tianjin, 300071, P. R. China.
FAU - Yang, Zhimou
AU  - Yang Z
AUID- ORCID: 0000-0003-2967-6920
AD  - Key Laboratory of Bioactive Materials, Ministry of Education, College of Life 
      Sciences, State Key Laboratory of Medicinal Chemical Biology, National Institute 
      for Advanced Materials, and Collaborative Innovation Center of Chemical Science 
      and Engineering, Nankai University, Tianjin, 300071, P. R. China.
AD  - Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer 
      Institute, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, P. R. China.
LA  - eng
GR  - 31825012/National Science Fund for Distinguished Young Scholars/
GR  - 2017YFC1103502/National Key Research and Development Program of China/
GR  - 21875116/NSFC/
GR  - 17JCJQJC44900/Tianjin Science Fund for Distinguished Young Scholars/
GR  - TJSQNTJ-2017-16/Young Elite Scientists Sponsorship Program by Tianjin/
GR  - Fundamental Research Funds for the Central Universities/
PT  - Journal Article
PT  - Review
DEP - 20190424
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 0 (Enzymes)
RN  - 0 (Hydrogels)
RN  - 0 (Peptides)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Enzymes/*metabolism
MH  - Humans
MH  - Hydrogels/*chemistry/metabolism
MH  - Kinetics
MH  - Matrix Metalloproteinases/metabolism
MH  - Mitochondria/metabolism
MH  - Nanofibers/chemistry
MH  - Neoplasms/diagnosis
MH  - Optical Imaging/methods
MH  - Peptides/chemistry/*metabolism
OTO - NOTNLM
OT  - enzymes
OT  - hydrogels
OT  - peptides
OT  - self-assembly
EDAT- 2019/04/25 06:00
MHDA- 2020/10/22 06:00
CRDT- 2019/04/25 06:00
PHST- 2018/09/06 00:00 [received]
PHST- 2019/02/19 00:00 [revised]
PHST- 2019/04/25 06:00 [pubmed]
PHST- 2020/10/22 06:00 [medline]
PHST- 2019/04/25 06:00 [entrez]
AID - 10.1002/adma.201805798 [doi]
PST - ppublish
SO  - Adv Mater. 2020 Jan;32(3):e1805798. doi: 10.1002/adma.201805798. Epub 2019 Apr 
      24.