PMID- 31018894
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 40
IP  - 3
DP  - 2019 May 1
TI  - A new score to predict allergic march in patients with IgE-mediated cow milk 
      allergy.
PG  - 187-192
LID - 10.2500/aap.2019.40.4208 [doi]
AB  - Background: Cow milk allergy (CMA) is the most common food allergy in infants. 
      Some patients will express, in the future, other allergic diseases (allergic 
      march). Objective: To evaluate if a new scoring system could determine the risk 
      of developing allergic march. Methods: A retrospective observational cohort study 
      of subjects who were immunoglobulin E (IgE) mediated was conducted. We defined a 
      risk score for atopy (RSA), including clinical and laboratory variables. Three 
      risk groups were defined according to the RSA. We defined as dependent variables 
      atopy (one or more allergic diseases) and atopy+ (two or more allergic diseases). 
      A multivariate logistic regression model was created, which included RSA and the 
      type of formula (high-grade extended hydrolyzed formula [EHF] with Lactobacillus 
      rhamnosus GG (LGG), high-grade EHF without LGG, and other formulas). Results: A 
      total of 211 patients were recruited. When we analyzed the risk of atopy+, we 
      found an increased risk for RSA intermediate-risk (odds ratio [OR 2.08] [95% 
      confidence interval CI, 0.95-4.56) and high-risk (OR 24.74 [95% CI, 
      6.26-97.73]) groups, and a decreased risk for the subjects fed with high-grade 
      EHF (OR 0.42 [95% CI, 0.20-0.87]) and also in those subjects fed with high-grade 
      EHF plus LGG (OR 0.30 [95% CI, 0.09-0.98]). Conclusion: RSA is a simple and 
      useful tool to predict the risk of developing other allergic diseases in patients 
      with IgE-mediated CMA.
FAU - Gil, Francisco
AU  - Gil F
FAU - Mendizabal, Mikel
AU  - Mendizabal M
FAU - Amezqueta, Ana
AU  - Amezqueta A
FAU - Aznal, Elena
AU  - Aznal E
FAU - Dura, Teodoro
AU  - Dura T
FAU - Sanchez-Valverde, Felix
AU  - Sanchez-Valverde F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Animals
MH  - Cattle
MH  - Child
MH  - Female
MH  - Humans
MH  - Hydrolysis
MH  - Immunoglobulin E/blood/*immunology
MH  - Male
MH  - Milk/*adverse effects
MH  - Milk Hypersensitivity/diagnosis/*immunology
MH  - Probiotics
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2019/04/26 06:00
MHDA- 2020/04/21 06:00
CRDT- 2019/04/26 06:00
PHST- 2019/04/26 06:00 [entrez]
PHST- 2019/04/26 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
AID - 10.2500/aap.2019.40.4208 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2019 May 1;40(3):187-192. doi: 10.2500/aap.2019.40.4208.