PMID- 31019174
OWN - NLM
STAT- MEDLINE
DCOM- 20190613
LR  - 20190613
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 60
IP  - 3
DP  - 2019 May 30
TI  - Increased Plasma Soluble Fractalkine in Patients with Chronic Heart Failure and 
      Its Clinical Significance.
PG  - 701-707
LID - 10.1536/ihj.18-422 [doi]
AB  - Fractalkine has been reported to play an important role in the pathophysiology of 
      various cardiovascular disorders. This research aims to study the change of 
      soluble fractalkine (sFKN) in plasma level of patients with chronic heart failure 
      (CHF) and evaluate its prognostic value.A total of 96 patients with CHF and 45 
      healthy subjects were included in this study. The plasma levels of sFKN, brain 
      natriuretic peptide (BNP), and Interleukin-18 (IL-18) were determined by ELISA 
      kits when they were first admitted to the hospital. Left ventricular ejection 
      fraction (LVEF) was measured by echocardiogram. Rehospitalization status within 1 
      year after the first hospitalization was also recorded.The plasma levels of sFKN, 
      BNP, and IL-18 in patients with CHF were significantly higher than in the control 
      group (P < 0.05). The concentrations of sFKN and BNP were increased with the 
      severity of heart failure classified by NYHA classification (P < 0.05). There 
      were no statistical differences among all CHF subgroups classified by etiology (P 
      > 0.05). Plasma sFKN level in CHF group was positively correlated with BNP (r = 
      0.441, P < 0.001) and IL-18 (r = 0.592, P < 0.001). Receiver operating 
      characteristic curve analysis showed that area under the curve values of FKN, 
      BNP, and IL-18 were 0.885 (95%CI: 0.810 to 0.960, P < 0.001), 0.889 (95%CI: 0.842 
      to 0.956, P < 0.001), and 0.878 (95%CI: 0.801-0.954, P < 0.001), respectively. 
      The concentrations of sFKN and BNP were increased in patients readmitted more 
      than once within 1 year (P < 0.05).
FAU - Ji, Cui-Ling
AU  - Ji CL
AD  - Department of Cardiology II, The Affiliated Hospital of Jining Medical 
      University.
FAU - Nomi, Adnan
AU  - Nomi A
AD  - Teaching and Research Section of International Students, Jining Medical 
      University.
FAU - Li, Bin
AU  - Li B
AD  - Department of Cardiology IV, The Affiliated Hospital of Jining Medical 
      University.
FAU - Shen, Cheng
AU  - Shen C
AD  - Department of Cardiology II, The Affiliated Hospital of Jining Medical 
      University.
FAU - Song, Bing-Chun
AU  - Song BC
AD  - Department of Cardiology II, The Affiliated Hospital of Jining Medical 
      University.
FAU - Zhang, Jin-Guo
AU  - Zhang JG
AD  - Department of Cardiology II, The Affiliated Hospital of Jining Medical 
      University.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190425
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (Interleukin-18)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CX3CL1/*blood/metabolism
MH  - Chronic Disease
MH  - Echocardiography/methods
MH  - Female
MH  - Heart Failure/*blood/classification/metabolism/mortality
MH  - Humans
MH  - Interleukin-18/blood
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Patient Readmission/statistics & numerical data
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Stroke Volume/*physiology
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - Bain natriuretic peptide
OT  - Inflammatory immune
EDAT- 2019/04/26 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/04/26 06:00
PHST- 2019/04/26 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/04/26 06:00 [entrez]
AID - 10.1536/ihj.18-422 [doi]
PST - ppublish
SO  - Int Heart J. 2019 May 30;60(3):701-707. doi: 10.1536/ihj.18-422. Epub 2019 Apr 
      25.