PMID- 31019180
OWN - NLM
STAT- MEDLINE
DCOM- 20190613
LR  - 20190613
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 60
IP  - 3
DP  - 2019 May 30
TI  - Predictive Values of Apelin for Myocardial Fibrosis in Hypertrophic 
      Cardiomyopathy.
PG  - 648-655
LID - 10.1536/ihj.18-598 [doi]
AB  - Apelin was proved to attenuate cardiac interstitial fibrosis. However, the 
      association between apelin level and myocardial fibrosis in patients with 
      hypertrophic cardiomyopathy (HCM) is still unclear.This study aims to determine 
      whether apelin is associated with myocardial fibrosis in HCM and investigate the 
      predictive values of apelin for myocardial fibrosis in HCM.One hundred sixteen 
      patients with HCM were enrolled in this study. Plasma apelin-13 and 
      high-sensitivity cardiac troponin I (cTNI) were measured. The cardiac systolic 
      and diastolic functions were evaluated by echocardiography, and the presence and 
      extent of cardiac fibrosis were assessed by cardiac magnetic resonance. All 
      statistical data were analyzed by SPSS version 21.0.The percentage of late 
      gadolinium enhancement (LGE) was negatively correlated with apelin and positively 
      correlated with cTNI, maximum wall thickness (MWT), and left ventricular mass 
      index in the overall patients with HCM and LGE. Apelin, cTNI, MWT, and left 
      ventricular ejection fraction were independent predictors of the presence of LGE. 
      The cutoff values of apelin, cTNI, and MWT were 1.24 pg/mL, 0.031 ng/mL, and 19 
      mm, respectively, for the prediction of LGE. The combined measurements of MWT >/= 
      19 mm and/or apelin </= 1.24 pg/mL, as well as the combined measurements of MWT >/= 
      19 mm and/or cTNI >/= 0.031 ng/mL, obtained higher specificity and higher 
      sensitivity, thus, indicating the presence of LGE.Plasma apelin and cTNI are 
      independent predictors of myocardial fibrosis. The combined measurements of serum 
      apelin and MWT, as well as cTNI and MWT, showed higher predictive values for 
      predicting myocardial fibrosis in patients with HCM.
FAU - Zhou, Ying
AU  - Zhou Y
AD  - Department of Cardiology, China-Japan Friendship Hospital.
FAU - Yuan, Jiansong
AU  - Yuan J
AD  - Department of Cardiology, Chinese Academy of Medical Sciences and Peking Union 
      Medical College Fuwai Hospital.
FAU - Wang, Yong
AU  - Wang Y
AD  - Department of Cardiology, China-Japan Friendship Hospital.
FAU - Qiao, Shubin
AU  - Qiao S
AD  - Department of Cardiology, Chinese Academy of Medical Sciences and Peking Union 
      Medical College Fuwai Hospital.
LA  - eng
PT  - Journal Article
DEP - 20190425
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (APLN protein, human)
RN  - 0 (Apelin)
RN  - 0 (Biomarkers)
RN  - 0 (Troponin I)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Apelin/*blood
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Hypertrophic/*complications/metabolism
MH  - Endomyocardial Fibrosis/*diagnostic imaging/metabolism
MH  - Female
MH  - Gadolinium/metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Troponin I/*blood
OTO - NOTNLM
OT  - MWT
OT  - Prediction of fibrosis in heart
OT  - cTNI
EDAT- 2019/04/26 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/04/26 06:00
PHST- 2019/04/26 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/04/26 06:00 [entrez]
AID - 10.1536/ihj.18-598 [doi]
PST - ppublish
SO  - Int Heart J. 2019 May 30;60(3):648-655. doi: 10.1536/ihj.18-598. Epub 2019 Apr 
      25.