PMID- 31019719
OWN - NLM
STAT- MEDLINE
DCOM- 20200304
LR  - 20200309
IS  - 2054-4200 (Electronic)
IS  - 2054-4200 (Linking)
VI  - 4
DP  - 2019
TI  - Non-alcoholic fatty liver disease in Africa: a hidden danger.
PG  - e3
LID - 10.1017/gheg.2019.2 [doi]
LID - e3
AB  - There is a dearth of data on the burden and spectrum of non-alcoholic fatty liver 
      disease (NAFLD) in African populations. The limited available information 
      suggests that the prevalence of NAFLD in the general population is lowest for the 
      Africa region. However, this is likely to be an underestimate and also does not 
      take into consideration the long-term impact of rising rates of obesity, type-2 
      diabetes mellitus (T2DM) and high human immunodeficiency virus infection burden 
      in Africa. A racial disparity in the prevalence of NAFLD has been observed in 
      some studies but remains unexplained. There is an absence of data from 
      population-based studies in Africa and this highlights the need for such studies, 
      to reliably define the health service needs for this region. Screening for NAFLD 
      at a population-based level using ultrasound is perhaps the ideal method for 
      resource-poor settings because of its relative cost-effectiveness. What is 
      required as a priority from Africa, are well-designed epidemiologic studies that 
      screen for NAFLD in the general population as well as high-risk groups such as 
      patients with T2DM or obesity.
FAU - Paruk, Imran M
AU  - Paruk IM
AUID- ORCID: 0000-0002-6720-8450
AD  - Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Nelson R 
      Mandela School of Medicine, Durban, South Africa.
FAU - Pirie, Fraser J
AU  - Pirie FJ
AD  - Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Nelson R 
      Mandela School of Medicine, Durban, South Africa.
FAU - Motala, Ayesha A
AU  - Motala AA
AD  - Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Nelson R 
      Mandela School of Medicine, Durban, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20190412
PL  - England
TA  - Glob Health Epidemiol Genom
JT  - Global health, epidemiology and genomics
JID - 101703450
SB  - IM
MH  - Africa/epidemiology
MH  - Cost of Illness
MH  - Diabetes Mellitus, Type 2/complications/epidemiology
MH  - HIV Infections/complications/epidemiology
MH  - Health Services Needs and Demand/*statistics & numerical data
MH  - Humans
MH  - Insulin Resistance
MH  - Non-alcoholic Fatty Liver Disease/*diagnostic imaging/*epidemiology/mortality
MH  - Obesity/complications/epidemiology
MH  - Prevalence
MH  - Risk Factors
MH  - Ultrasonography/economics
PMC - PMC6465678
OTO - NOTNLM
OT  - Africa
OT  - non-alcoholic fatty liver disease
OT  - non-alcoholic steatohepatitis
OT  - obesity
OT  - type-2 diabetes
EDAT- 2019/04/26 06:00
MHDA- 2020/03/05 06:00
PMCR- 2019/04/12
CRDT- 2019/04/26 06:00
PHST- 2019/01/15 00:00 [received]
PHST- 2019/03/05 00:00 [revised]
PHST- 2019/03/07 00:00 [accepted]
PHST- 2019/04/26 06:00 [entrez]
PHST- 2019/04/26 06:00 [pubmed]
PHST- 2020/03/05 06:00 [medline]
PHST- 2019/04/12 00:00 [pmc-release]
AID - 00002 [pii]
AID - 10.1017/gheg.2019.2 [doi]
PST - epublish
SO  - Glob Health Epidemiol Genom. 2019 Apr 12;4:e3. doi: 10.1017/gheg.2019.2. 
      eCollection 2019.