PMID- 3101978
OWN - NLM
STAT- MEDLINE
DCOM- 19870415
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 401
IP  - 1
DP  - 1987 Jan 13
TI  - Differential and asymmetrical behavioral effects of electrolytic or 
      6-hydroxydopamine lesions in the nucleus accumbens.
PG  - 147-51
AB  - Sprague-Dawley rats received either unilateral or bilateral electrolytic or 
      6-hydroxydopamine (6-OHDA) lesions in the nucleus accumbens (n. acc.) and daily 
      spontaneous activity was measured in home cage running wheels for 30 days 
      postoperatively. Bilateral electrolytic lesions increased activity to 230% of 
      preoperative baseline. Right electrolytic lesions produced a 50% increase in 
      activity while left lesion rats were not significantly different from 
      sham-operated controls. Conversely, 6-OHDA lesions depressed activity. Bilateral 
      6-OHDA lesions had the greatest depressant effect upon activity while unilateral 
      left or right n. acc. treatments produced relatively less hypoactivity. Results 
      support an asymmetrically organized serial inhibition model of spontaneous 
      locomotor control.
FAU - Kubos, K L
AU  - Kubos KL
FAU - Moran, T H
AU  - Moran TH
FAU - Robinson, R G
AU  - Robinson RG
LA  - eng
GR  - MH 00163/MH/NIMH NIH HHS/United States
GR  - NS 15178/NS/NINDS NIH HHS/United States
GR  - NS 8622/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Hydroxydopamines)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Dopamine/physiology
MH  - Hydroxydopamines/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects/*physiology
MH  - Neural Pathways/physiology
MH  - Nucleus Accumbens/drug effects/*physiology
MH  - Oxidopamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Septal Nuclei/*physiology
EDAT- 1987/01/13 00:00
MHDA- 1987/01/13 00:01
CRDT- 1987/01/13 00:00
PHST- 1987/01/13 00:00 [pubmed]
PHST- 1987/01/13 00:01 [medline]
PHST- 1987/01/13 00:00 [entrez]
AID - 0006-8993(87)91174-7 [pii]
AID - 10.1016/0006-8993(87)91174-7 [doi]
PST - ppublish
SO  - Brain Res. 1987 Jan 13;401(1):147-51. doi: 10.1016/0006-8993(87)91174-7.