PMID- 31020299
OWN - NLM
STAT- MEDLINE
DCOM- 20200102
LR  - 20211204
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 10
IP  - 5
DP  - 2019 May 22
TI  - PHMH, a diarylheptanoid from Alpinia officinarum attenuates VEGF-induced 
      angiogenesis via inhibition of the VEGFR-2 signaling pathway.
PG  - 2605-2617
LID - 10.1039/c8fo01809j [doi]
AB  - The rhizome of Alpinia officinarum Hance, a popular spice used as a condiment in 
      China and Europe, has various reported bioactivities, including anticancer, 
      anti-inflammatory and antioxidant effects. However, its anti-angiogenic activity 
      has not previously been reported. In this study, a diarylheptanoid was isolated 
      from Alpinia officinarum and identified as 
      1-phenyl-7-(4-hydroxy-3-methoxyphenyl)-4E-en-3-heptanone (PHMH). We demonstrated 
      that PHMH exerts anti-angiogenic activity both in vitro and in vivo. PHMH 
      inhibited vascular endothelial growth factor (VEGF)-induced viability, migration, 
      invasion and tube formation in human umbilical vein endothelial cells (HUVECs) in 
      vitro, and also suppressed VEGF-induced sprout formation of rat aorta ex vivo. 
      Furthermore, PHMH was found to block VEGF-induced vessel formation in mice and 
      suppress angiogenesis in both zebrafish and chorioallantoic membrane models. 
      Mechanistic studies indicated that PHMH inhibited VEGF-induced VEGF receptor-2 
      (VEGFR-2) auto-phosphorylation and resulted in the blockage of VEGFR-2-mediated 
      signaling cascades in HUVECs, including the Akt/mTOR, ERK1/2, and FAK pathways. 
      Our findings provide new insights into the potential application of PHMH as a 
      therapeutic agent for anti-angiogenesis.
FAU - Hu, Liubing
AU  - Hu L
AD  - Guangdong Provincial Key Laboratory of Bioengineering Medicine, Institute of 
      Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 
      510632, People's Republic of China. tliuzh@jnu.edu.cn.
FAU - Huang, Weihuan
AU  - Huang W
FAU - Ding, Yong
AU  - Ding Y
FAU - Liu, Min
AU  - Liu M
FAU - Wang, Mei
AU  - Wang M
FAU - Wang, Ying
AU  - Wang Y
FAU - Zhang, Wei
AU  - Zhang W
FAU - Li, Yaolan
AU  - Li Y
FAU - Ye, Wencai
AU  - Ye W
FAU - Li, Manmei
AU  - Li M
FAU - Liu, Zhong
AU  - Liu Z
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (1-(4-hydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-one)
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Diarylheptanoids)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Alpinia
MH  - Angiogenesis Inhibitors/*administration & dosage/chemistry
MH  - Animals
MH  - Cell Movement/drug effects
MH  - China
MH  - Diarylheptanoids/*administration & dosage/chemistry
MH  - Drugs, Chinese Herbal/*administration & dosage/chemistry
MH  - Female
MH  - Human Umbilical Vein Endothelial Cells/drug effects/metabolism
MH  - Humans
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Neovascularization, Pathologic/*drug therapy/genetics/metabolism/physiopathology
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases/genetics/metabolism
MH  - Vascular Endothelial Growth Factor A/*metabolism
MH  - Vascular Endothelial Growth Factor Receptor-2/genetics/*metabolism
MH  - Zebrafish
EDAT- 2019/04/26 06:00
MHDA- 2020/01/03 06:00
CRDT- 2019/04/26 06:00
PHST- 2019/04/26 06:00 [pubmed]
PHST- 2020/01/03 06:00 [medline]
PHST- 2019/04/26 06:00 [entrez]
AID - 10.1039/c8fo01809j [doi]
PST - ppublish
SO  - Food Funct. 2019 May 22;10(5):2605-2617. doi: 10.1039/c8fo01809j.