PMID- 31021708
OWN - NLM
STAT- MEDLINE
DCOM- 20191018
LR  - 20191018
IS  - 1938-5404 (Electronic)
IS  - 0033-7587 (Linking)
VI  - 192
IP  - 1
DP  - 2019 Jul
TI  - Translocation Frequency in Patients with Repeated CT Exposure: Comparison with 
      CT-Naive Patients.
PG  - 23-27
LID - 10.1667/RR15286.1 [doi]
AB  - Epidemiologic studies using clinical indicators are limited in the assessment of 
      the biological effects of low-dose ionizing radiation for medical purposes. We 
      evaluated the biological effect of low-dose radiation by comparing translocation 
      frequencies in patients with repeated computed tomography (CT) exposure and 
      CT-naive patients. The goal of this prospective case-control study was to 
      determine whether repeated CT exposure is associated with increased frequency in 
      chromosomal translocations. Two cohorts, comprised of case patients with a 
      history of repeated CT exposure and age- and sex-matched CT-naive control 
      patients (n = 48 per cohort), were consecutively enrolled in this 
      single-institution study. CT-radiation exposure was estimated using dose-length 
      products, and translocation frequencies of peripheral blood lymphocytes were 
      assessed using whole chromosome paints by fluorescence in situ hybridization 
      (FISH). Comparison of translocation frequencies between cases and controls was 
      performed using the Wilcoxon rank sum test (paired samples), and the relationship 
      between cumulative radiation exposure and translocation frequency was assessed 
      using a partial correlation analysis. Translocation frequencies were 
      significantly different between cases and controls (P = 0.0003). The median 
      translocation frequency was 7 [95% confidence interval (CI): 6, 8] for cases and 
      4 (95% CI: 3, 6) for controls. By using cumulative radiation exposure as the 
      effect variable and translocation frequency as the response variable, we found a 
      significant correlation between cumulative radiation exposure and translocation 
      frequency (r = 0.6579, P < 0.0001). Chromosomal translocations were more frequent 
      with repeated CT-exposed patients than in CT-naive patients, and a positive 
      dose-response relationship was present between cumulative radiation exposure and 
      translocation frequency.
FAU - Lee, Jin Kyung
AU  - Lee JK
AD  - a Department of Laboratory Medicine.
FAU - Lee, Myoung Seok
AU  - Lee MS
AD  - c Korea Institute of Radiological Radiology, Seoul National University College of 
      Medicine, Seoul, South Korea.
FAU - Moon, Min Hoan
AU  - Moon MH
AD  - c Korea Institute of Radiological Radiology, Seoul National University College of 
      Medicine, Seoul, South Korea.
FAU - Woo, Hyunsik
AU  - Woo H
AD  - c Korea Institute of Radiological Radiology, Seoul National University College of 
      Medicine, Seoul, South Korea.
FAU - Hong, Young Jun
AU  - Hong YJ
AD  - a Department of Laboratory Medicine.
FAU - Jang, Seongjae
AU  - Jang S
AD  - b Department of Laboratory of Biological Dosimetry, Korea Cancer Center Hospital, 
      Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
FAU - Oh, Sohee
AU  - Oh S
AD  - d Department of Biostatistics, SMG-SNU Boramae Medical Center, Seoul National 
      University College of Medicine, Seoul, South Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190425
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiation Exposure/*adverse effects
MH  - Time Factors
MH  - Tomography, X-Ray Computed/*adverse effects
MH  - Translocation, Genetic/*radiation effects
MH  - Young Adult
EDAT- 2019/04/26 06:00
MHDA- 2019/10/19 06:00
CRDT- 2019/04/26 06:00
PHST- 2019/04/26 06:00 [pubmed]
PHST- 2019/10/19 06:00 [medline]
PHST- 2019/04/26 06:00 [entrez]
AID - 10.1667/RR15286.1 [pii]
AID - 10.1667/RR15286.1 [doi]
PST - ppublish
SO  - Radiat Res. 2019 Jul;192(1):23-27. doi: 10.1667/RR15286.1. Epub 2019 Apr 25.