PMID- 31022051
OWN - NLM
STAT- MEDLINE
DCOM- 20190716
LR  - 20190716
IS  - 1536-1004 (Electronic)
IS  - 0899-3459 (Linking)
VI  - 28
IP  - 2
DP  - 2019 Apr
TI  - Neuroimaging and Stereotactic Body Radiation Therapy (SBRT) for Spine Metastasis.
PG  - 85-96
LID - 10.1097/RMR.0000000000000199 [doi]
AB  - Historically, management options for spinal metastases include surgery for 
      stabilization and decompression and/or external beam radiation therapy (EBRT). 
      EBRT is palliative in nature, as it lacks accurate targeting such that the 
      prescribed radiation doses must be limited in order to maintain safety. Modern 
      advancement in imaging and radiotherapy technology have facilitated the 
      development of stereotactic body radiation therapy (SBRT), which provides 
      increased targeted precision for radiation delivery to tumors resulting in lower 
      overall toxicity, particularly to regional structures such as the spinal cord and 
      esophagus, while delivering higher, more effective, and radically ablative 
      radiation doses.Over the past decade, SBRT has been increasingly utilized as a 
      method of treating spinal metastases either as the primary modality or following 
      surgical intervention in both de novo and reirradiation setting. Numerous studies 
      suggest that SBRT is associated with an 80% to 90% rate of 1-year local control 
      across clinical scenarios. For example, studies of SBRT as the primary treatment 
      modality suggest long-term local control rate of 80% to 95% for spinal 
      metastases. Similarly, SBRT in the adjuvant setting following surgery is 
      associated with local control rates ranging from 70% to 100%. Furthermore, 
      because SBRT allows for lower dose to the spinal cord, it has also been used in 
      patients who have had prior radiation therapy, with studies showing 66% to 93% 
      local control in this scenario.
FAU - Khan, Majid
AU  - Khan M
AD  - The Johns Hopkins University, Baltimore, MD.
FAU - Garg, Rahul
AU  - Garg R
AD  - The Johns Hopkins University, Baltimore, MD.
FAU - Gui, Chengcheng
AU  - Gui C
AD  - The Johns Hopkins University, Baltimore, MD.
FAU - Lee, Young
AU  - Lee Y
AD  - Odette Cancer Centre-Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
FAU - Sahgal, Arjun
AU  - Sahgal A
AD  - Odette Cancer Centre-Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
FAU - Mossa-Basha, Mahmud
AU  - Mossa-Basha M
AD  - The University of Washington, Seattle, WA.
FAU - Mayr, Nina
AU  - Mayr N
AD  - The University of Washington, Seattle, WA.
FAU - Lo, Simon
AU  - Lo S
AD  - The University of Washington, Seattle, WA.
FAU - Redmond, Kristin
AU  - Redmond K
AD  - The Johns Hopkins University, Baltimore, MD.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Top Magn Reson Imaging
JT  - Topics in magnetic resonance imaging : TMRI
JID - 8913523
SB  - IM
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Neuroimaging/*methods
MH  - Radiosurgery/*methods
MH  - Spinal Neoplasms/*radiotherapy/*secondary
MH  - Spine/diagnostic imaging
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2019/04/26 06:00
MHDA- 2019/07/17 06:00
CRDT- 2019/04/26 06:00
PHST- 2019/04/26 06:00 [entrez]
PHST- 2019/04/26 06:00 [pubmed]
PHST- 2019/07/17 06:00 [medline]
AID - 00002142-201904000-00006 [pii]
AID - 10.1097/RMR.0000000000000199 [doi]
PST - ppublish
SO  - Top Magn Reson Imaging. 2019 Apr;28(2):85-96. doi: 10.1097/RMR.0000000000000199.