PMID- 31024458
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 10
DP  - 2019
TI  - Gene Lifestyle Interactions With Relation to Obesity, Cardiometabolic, and 
      Cardiovascular Traits Among South Asians.
PG  - 221
LID - 10.3389/fendo.2019.00221 [doi]
LID - 221
AB  - The rapid rise of obesity, type 2 diabetes mellitus (T2DM) and cardiovascular 
      disease (CVD) during the last few decades among South Asians has been largely 
      attributed to a major shift in lifestyles including physical inactivity, 
      unhealthy dietary patterns, and an overall pattern of sedentary lifestyle. 
      Genetic predisposition to these cardiometabolic risk factors may have interacted 
      with these obesogenic environments in determining the higher cardiometabolic 
      disease prevalence. Based on the premise that gene-environment interactions cause 
      obesity and cardiometabolic diseases, we systematically searched the literature 
      and considered the knowledge gaps that future studies might fulfill. We 
      identified only seven published studies that focused specifically on 
      gene-environment interactions for cardiometabolic traits in South Asians, most of 
      which were limited by relatively small sample and lack of replication. Some 
      studies reported that the differences in metabolic response to higher physical 
      activity and low caloric diet might be modified by genetic risk related to these 
      cardiometabolic traits. Although studies on gene lifestyle interactions in 
      cardiometabolic traits report significant interactions, future studies must focus 
      on more precise assessment of lifestyle factors, investigation of a larger set of 
      genetic variants and the application of powerful statistical methods to 
      facilitate translatable approaches. Future studies should also be integrated with 
      findings both using mechanistic studies through laboratory settings and 
      randomized clinical trials for clinical outcomes.
FAU - Ahmad, Shafqat
AU  - Ahmad S
AD  - Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 
      Uppsala, Sweden.
AD  - Preventive Medicine Division, Harvard Medical School, Brigham and Women's 
      Hospital, Boston, MA, United States.
AD  - Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, 
      United States.
FAU - Fatima, Syeda Sadia
AU  - Fatima SS
AD  - Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, 
      Pakistan.
FAU - Rukh, Gull
AU  - Rukh G
AD  - Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, 
      Sweden.
FAU - Smith, Caren E
AU  - Smith CE
AD  - Nutrition and Genomics Laboratory, Jean Mayer U. S. Department of Agriculture 
      Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United 
      States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190409
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6465946
OTO - NOTNLM
OT  - South Asians
OT  - cardiometabolic traits
OT  - cardiovasclar disease
OT  - gene environment interaction
OT  - obesity
EDAT- 2019/04/27 06:00
MHDA- 2019/04/27 06:01
PMCR- 2019/01/01
CRDT- 2019/04/27 06:00
PHST- 2018/11/03 00:00 [received]
PHST- 2019/03/20 00:00 [accepted]
PHST- 2019/04/27 06:00 [entrez]
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2019/04/27 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2019.00221 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2019 Apr 9;10:221. doi: 10.3389/fendo.2019.00221. 
      eCollection 2019.