PMID- 31024619
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 10
DP  - 2019
TI  - A Positive Causal Influence of IL-18 Levels on the Risk of T2DM: A Mendelian 
      Randomization Study.
PG  - 295
LID - 10.3389/fgene.2019.00295 [doi]
LID - 295
AB  - A large number of clinical studies have shown that interleukin-18 (IL-18) plasma 
      levels are positively correlated with the pathogenesis and development of type 2 
      diabetes mellitus (T2DM), but it remains unclear whether IL-18 causes T2DM, 
      primarily due to the influence of reverse causality and residual confounding 
      factors. Genome-wide association studies have led to the discovery of numerous 
      common variants associated with IL-18 and T2DM and opened unprecedented 
      opportunities for investigating possible associations between genetic traits and 
      diseases. In this study, we employed a two-sample Mendelian randomization (MR) 
      method to analyze the causal relationships between IL-18 plasma levels and T2DM 
      using IL18-related SNPs as genetic instrumental variables (IVs). We first 
      selected eight SNPs that were significantly associated with IL-18 but independent 
      of T2DM. We then used these SNPs as IVs to evaluate their effects on T2DM using 
      the inverse-variance weighted (IVW) method. Finally, we conducted sensitivity 
      analysis and MR-Egger regression analysis to evaluate the heterogeneity and 
      pleiotropic effects of each variant. The results based on the IVW method 
      demonstrate that high IL-18 plasma levels significantly increase the risk of 
      T2DM, and no heterogeneity or pleiotropic effects appeared after the sensitivity 
      and MR-Egger analyses.
FAU - Zhuang, He
AU  - Zhuang H
AD  - Systemomics Center, College of Pharmacy, and Genomics Research Center 
      (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 
      Medical University, Harbin, China.
FAU - Han, Junwei
AU  - Han J
AD  - College of Bioinformatics Science and Technology, Harbin Medical University, 
      Harbin, China.
FAU - Cheng, Liang
AU  - Cheng L
AD  - College of Bioinformatics Science and Technology, Harbin Medical University, 
      Harbin, China.
FAU - Liu, Shu-Lin
AU  - Liu SL
AD  - Systemomics Center, College of Pharmacy, and Genomics Research Center 
      (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 
      Medical University, Harbin, China.
AD  - Department of Microbiology, Immunology and Infectious Diseases, University of 
      Calgary, Calgary, AB, Canada.
LA  - eng
PT  - Journal Article
DEP - 20190405
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC6459887
OTO - NOTNLM
OT  - Mendelian randomization
OT  - casual effect
OT  - genome-wide association studies
OT  - interleukin-18 levels
OT  - type 2 diabetes mellitus
EDAT- 2019/04/27 06:00
MHDA- 2019/04/27 06:01
PMCR- 2019/04/05
CRDT- 2019/04/27 06:00
PHST- 2019/01/10 00:00 [received]
PHST- 2019/03/19 00:00 [accepted]
PHST- 2019/04/27 06:00 [entrez]
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2019/04/27 06:01 [medline]
PHST- 2019/04/05 00:00 [pmc-release]
AID - 10.3389/fgene.2019.00295 [doi]
PST - epublish
SO  - Front Genet. 2019 Apr 5;10:295. doi: 10.3389/fgene.2019.00295. eCollection 2019.