PMID- 31025261
OWN - NLM
STAT- MEDLINE
DCOM- 20200529
LR  - 20200529
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 65
IP  - 1
DP  - 2019 Jul
TI  - Phenotypic characterization of a novel type 2 diabetes animal model in a SHANXI 
      MU colony of Chinese hamsters.
PG  - 61-72
LID - 10.1007/s12020-019-01940-x [doi]
AB  - PURPOSE: Developing animal models for human diseases is critical for studying 
      complex diseases such as type 2 diabetes mellitus (T2DM). Since inbred colonies 
      of Chinese hamsters tend toward spontaneous development of diabetes, we 
      investigated them as a possible model. METHODS: We regarded individuals with 
      fasting blood glucose (FBG) higher than 6.0 mmol/L and post-prandial blood 
      glucose (PBG) higher than 7.0 mmol/L as diabetic based on the mean and 95% 
      frequency distribution values of FBG and PBG. Diabetic hamsters were 
      characterized based on metabolic profiles, histopathological features, and 
      changes in the expression of genes involved in glucose and lipid metabolism. 
      RESULTS: Metabolic analyses showed that diabetic hamsters exhibited mild 
      hyperglycemia, hypertriglyceridemia, glucose intolerance, and insulin resistance. 
      Histopathological analysis revealed that cell nuclei migrated inward in skeletal 
      muscle and obvious partial liver lipid deposition and focal necrosis was found. 
      We additionally observed mild injury, atrophy, and occasional vacuolization in 
      islet cells. Changes in the expression of several genes related to glucose and 
      lipid metabolism were observed. Decreased expression of adiponectin and GLUT4 and 
      increased expression of PPARgamma, Akt, and leptin was observed in skeletal muscle. 
      Decreased expression of adiponectin with increased expression of PPARgamma and leptin 
      was observed in the liver. CONCLUSIONS: These results indicate that we have 
      established a spontaneous diabetic hamster line that closely mimics human T2DM, 
      which may hold potential for further research on the pathogenesis and treatment 
      of this disease.
FAU - Wang, Lu
AU  - Wang L
AD  - Laboratory Animal Center of Shanxi Medical University, Shanxi Province, China.
AD  - Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human 
      Disease, Shanxi Medical University, Shanxi Province, China.
FAU - Wang, Chenyang
AU  - Wang C
AD  - Laboratory Animal Center of Shanxi Medical University, Shanxi Province, China.
AD  - Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human 
      Disease, Shanxi Medical University, Shanxi Province, China.
FAU - Zhang, Ruihu
AU  - Zhang R
AD  - Laboratory Animal Center of Shanxi Medical University, Shanxi Province, China.
AD  - Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human 
      Disease, Shanxi Medical University, Shanxi Province, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Pharmacology, Shanxi Medical University, Shanxi Province, China.
FAU - Wang, Chunfang
AU  - Wang C
AD  - Laboratory Animal Center of Shanxi Medical University, Shanxi Province, China.
AD  - Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human 
      Disease, Shanxi Medical University, Shanxi Province, China.
FAU - Song, Guohua
AU  - Song G
AD  - Laboratory Animal Center of Shanxi Medical University, Shanxi Province, China.
AD  - Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human 
      Disease, Shanxi Medical University, Shanxi Province, China.
FAU - Yu, Jingjing
AU  - Yu J
AD  - Laboratory Animal Center of Shanxi Medical University, Shanxi Province, China.
AD  - Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human 
      Disease, Shanxi Medical University, Shanxi Province, China.
FAU - Chen, Zhaoyang
AU  - Chen Z
AUID- ORCID: 0000-0002-6811-6945
AD  - Laboratory Animal Center of Shanxi Medical University, Shanxi Province, China. 
      ccytycn@163.com.
AD  - Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human 
      Disease, Shanxi Medical University, Shanxi Province, China. ccytycn@163.com.
LA  - eng
GR  - NO. 201605D121019/Shanxi Province Experimental Animal Resources Service Platform 
      of China/International
GR  - NO. 2015-054/Shanxi Scholarship Council of China/International
GR  - NO. 02201317/Shanxi Medical University Youth Fund Project of China/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190425
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Cricetinae
MH  - *Cricetulus
MH  - Diabetes Mellitus, Experimental/genetics/metabolism/*pathology
MH  - Diabetes Mellitus, Type 2/genetics/metabolism/*pathology
MH  - *Disease Models, Animal
MH  - Female
MH  - Gene Expression Regulation
MH  - Glucose Intolerance/genetics/metabolism
MH  - Humans
MH  - Insulin Resistance/genetics
MH  - Male
MH  - Phenotype
OTO - NOTNLM
OT  - Chinese hamster
OT  - Differentially expressed genes
OT  - Glucose intolerance
OT  - Insulin resistance
OT  - Type 2 diabetes mellitus
EDAT- 2019/04/27 06:00
MHDA- 2020/05/30 06:00
CRDT- 2019/04/27 06:00
PHST- 2018/12/12 00:00 [received]
PHST- 2019/04/17 00:00 [accepted]
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2020/05/30 06:00 [medline]
PHST- 2019/04/27 06:00 [entrez]
AID - 10.1007/s12020-019-01940-x [pii]
AID - 10.1007/s12020-019-01940-x [doi]
PST - ppublish
SO  - Endocrine. 2019 Jul;65(1):61-72. doi: 10.1007/s12020-019-01940-x. Epub 2019 Apr 
      25.