PMID- 31025465
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20200908
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 63
IP  - 9
DP  - 2019 Sep
TI  - Associations between electroencephalography power and Alzheimer's disease in 
      persons with Down syndrome.
PG  - 1151-1157
LID - 10.1111/jir.12627 [doi]
AB  - BACKGROUND: It is complicated to diagnose dementia in persons with Down syndrome 
      (DS). Older studies have, however, demonstrated low-frequency activity in 
      electroencephalography (EEG) in persons with concurrent DS and Alzheimer's 
      disease (DS-AD). The aim of this study was to examine whether it was possible to 
      identify AD-associated changes (increased high-frequency power and decreased 
      low-frequency power) in persons with DS-AD compared with DS. METHODS: We included 
      21 persons with DS-AD and 16 with DS without cognitive deterioration assessed by 
      the informant-based Dementia Screening Questionnaire in Intellectual Disability. 
      EEG was recorded for all participants. Absolute power for each electrode and 
      global power were calculated for all frequency bands for both eyes open and eyes 
      closed. RESULTS: For global power in the eyes closed condition, we found an 
      increased global slow-frequency activity and a decreased global high-frequency 
      activity in DS-AD compared with DS. In addition, we found a significant 
      difference in the global alpha/delta ratio with the largest difference found for 
      global alpha power in DS-AD compared with DS. CONCLUSIONS: In the current study, 
      we found that changes known to be associated with AD could also be identified 
      when comparing DS-AD with DS using quantitative EEG. In general, these findings 
      suggest that EEG might be a useful tool in diagnosing AD in persons with DS, but 
      larger studies are needed.
CI  - (c) 2019 MENCAP and International Association of the Scientific Study of 
      Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.
FAU - Musaeus, C S
AU  - Musaeus CS
AUID- ORCID: 0000-0002-6442-2910
AD  - Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Salem, L C
AU  - Salem LC
AD  - Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Sabers, A
AU  - Sabers A
AD  - The Epilepsy Clinic, Department of Neurology, Rigshospitalet-Blegdamsvej, 
      University Hospital, Copenhagen, Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
FAU - Kjaer, T W
AU  - Kjaer TW
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
AD  - Neurophysiology Center, Zealand University Hospital, Roskilde, Denmark.
FAU - Waldemar, G
AU  - Waldemar G
AD  - Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, 
      University of Copenhagen, Copenhagen, Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190425
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Adult
MH  - Alzheimer Disease/*diagnosis/epidemiology/physiopathology
MH  - Brain Waves/physiology
MH  - Comorbidity
MH  - Down Syndrome/*diagnosis/epidemiology/physiopathology
MH  - *Electroencephalography/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Down syndrome
OT  - EEG
OT  - dementia
OT  - power
EDAT- 2019/04/27 06:00
MHDA- 2020/09/09 06:00
CRDT- 2019/04/27 06:00
PHST- 2018/01/30 00:00 [received]
PHST- 2019/03/14 00:00 [revised]
PHST- 2019/03/20 00:00 [accepted]
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
PHST- 2019/04/27 06:00 [entrez]
AID - 10.1111/jir.12627 [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2019 Sep;63(9):1151-1157. doi: 10.1111/jir.12627. Epub 
      2019 Apr 25.