PMID- 31025528
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20191217
IS  - 1708-8208 (Electronic)
IS  - 1523-0899 (Linking)
VI  - 21
IP  - 3
DP  - 2019 Jun
TI  - Type 2 diabetes affects postextraction socket healing and influences first-stage 
      implant surgery: A study based on clinical and animal evidence.
PG  - 436-445
LID - 10.1111/cid.12780 [doi]
AB  - AIM: To verify the influence of type 2 diabetes mellitus (T2DM) on postextraction 
      socket healing and subsequent first-stage implant surgery. MATERIALS AND METHODS: 
      We analyzed pre-extraction and postextraction cone beam computed tomography 
      images of T2DM patients (n = 75) and paired nondiabetic controls to investigate 
      changes in postextraction socket and ridge dimensions. The types of guided bone 
      regeneration (GBR) surgeries were also compared. Three T2DM pig models were 
      established to compare their postextraction socket healing with that of 
      nondiabetic controls. Healing was quantitatively verified by microcomputed 
      tomography. The osteogenic differentiation of mesenchymal stem cells (MSCs) was 
      also compared. RESULTS: Compared to nondiabetic controls, T2DM patients had 
      higher socket width/depth values postextraction across all groups with different 
      healing times. Among the T2DM patients, 62.7% could not receive first-stage 
      implant surgery within 6 months postextraction, and 54.7% received GBR surgery 
      during first-stage surgery. Ossification was not achieved in the socket center of 
      the T2DM pig models after 3 months of healing. A decrease in osteogenic 
      differentiation was observed in T2DM-MSCs. CONCLUSIONS: T2DM interferes with the 
      healing of the extraction socket and thus delays first-stage implant surgery. 
      This phenomenon may be due to the reduced osteogenic differentiation of MSCs in 
      the sockets.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Zhang, Sijia
AU  - Zhang S
AD  - State Key Laboratory of Military Stomatology & National Clinical Research Center 
      for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and 
      Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The 
      Fourth Military Medical University, Xi'an, China.
AD  - Department of Biochemistry and Molecular Biology, Center for DNA Typing, Air 
      Force Medical University, 169 Changle West Road, Xi'an, Shaanxi 710032, P.R. 
      China.
FAU - Song, Shuang
AU  - Song S
AD  - Peking University, School of Stomatology, Beijing, China.
FAU - Wang, Shuyan
AU  - Wang S
AD  - State Key Laboratory of Military Stomatology & National Clinical Research Center 
      for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases, 
      Department of Oral Disease, School of Stomatology, The Fourth Military Medical 
      University, Xi'an, China.
FAU - Duan, Yansheng
AU  - Duan Y
AD  - State Key Laboratory of Military Stomatology & National Clinical Research Center 
      for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and 
      Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The 
      Fourth Military Medical University, Xi'an, China.
FAU - Zhu, Wenzhong
AU  - Zhu W
AD  - Department of Implant Dentistry, The Second People's Hospital, Xi'an, China.
FAU - Song, Yingliang
AU  - Song Y
AD  - State Key Laboratory of Military Stomatology & National Clinical Research Center 
      for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and 
      Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The 
      Fourth Military Medical University, Xi'an, China.
LA  - eng
GR  - 81771107/National Natural Science Foundation of China/
GR  - 81470775/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20190426
PL  - United States
TA  - Clin Implant Dent Relat Res
JT  - Clinical implant dentistry and related research
JID - 100888977
RN  - 0 (Dental Implants)
SB  - IM
MH  - Animals
MH  - *Dental Implants
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - Osteogenesis
MH  - Swine
MH  - *Tooth Extraction
MH  - *Tooth Socket
MH  - Wound Healing
MH  - X-Ray Microtomography
OTO - NOTNLM
OT  - alveolar ridge
OT  - extraction socket
OT  - implant surgery
OT  - pig model
OT  - type 2 diabetes mellitus
EDAT- 2019/04/27 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/04/27 06:00
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/04/27 06:00 [entrez]
AID - 10.1111/cid.12780 [doi]
PST - ppublish
SO  - Clin Implant Dent Relat Res. 2019 Jun;21(3):436-445. doi: 10.1111/cid.12780. Epub 
      2019 Apr 26.