PMID- 31025764 OWN - NLM STAT- MEDLINE DCOM- 20200313 LR - 20200313 IS - 1099-1166 (Electronic) IS - 0885-6230 (Linking) VI - 34 IP - 10 DP - 2019 Oct TI - Determinants of self- and carer-rated quality of life and caregiver burden in Alzheimer disease. PG - 1378-1385 LID - 10.1002/gps.5126 [doi] AB - OBJECTIVE: We aimed to investigate factors associated with self- and carer-rated quality of life (QoL) and caregiver burden related to very mild to severe clinical Alzheimer disease (AD). METHODS: One hundred patient-carer dyads were recruited, and assessments of relevant outcomes were performed, including sociodemographic characteristics, QoL, activities of daily living (ADL), cognitive performance, behavioural and psychological symptoms of dementia (BPSD), caregiver burden, and health resource utilisation. RESULTS: There was a strong correlation between carer- and self-rated QoL, with patients consistently rating their QoL higher than caregivers. Duration of illness did not affect the QoL ratings. There was an inverse association between both self- and carer-rated QoL with age, age at symptom onset, impairment of ADL, time spent on assisting the patient, and depression. Both self- and carer-rated QoL ratings were higher if the caregiver was a spouse vs a child. Carer-rated QoL was inversely associated with severity of dementia, BPSD, caregiver burden, and requirement to supervise the patient. The variables age at symptom onset, ADL, and living together with the primary caregiver explained 34.50% of the variance in self-rated QoL, whereas age at symptom onset, ADL, and BPSD explained 48.20% of the variance in carer-rated QoL. For caregiver burden, 26% of the variance was explained by the variables ADL, living together with the primary caregiver, and agitation. CONCLUSION: Our study highlights the need for a stronger focus on QoL in clinical AD research by providing further pieces of evidence on the key determinants, including the important aspect of caregiver burden. CI - (c) 2019 John Wiley & Sons, Ltd. FAU - Schumann, Christin AU - Schumann C AD - Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Alexopoulos, Panagiotis AU - Alexopoulos P AD - Department of Psychiatry, University Hospital of Rion, Faculty of Medicine, University of Patras, Patras, Greece. AD - Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany. FAU - Perneczky, Robert AU - Perneczky R AUID- ORCID: 0000-0003-1981-7435 AD - Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. AD - Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College, London, UK. AD - Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. LA - eng PT - Journal Article DEP - 20190508 PL - England TA - Int J Geriatr Psychiatry JT - International journal of geriatric psychiatry JID - 8710629 SB - IM CIN - Int J Geriatr Psychiatry. 2019 Dec;34(12):1916. PMID: 31407383 MH - Activities of Daily Living/psychology MH - Adaptation, Psychological MH - Aged MH - Aged, 80 and over MH - Alzheimer Disease/*psychology MH - Caregivers/*psychology MH - Cost of Illness MH - Female MH - Humans MH - Male MH - Mental Disorders/psychology MH - Middle Aged MH - Quality of Life/*psychology MH - Socioeconomic Factors OTO - NOTNLM OT - Alzheimer disease OT - behavioural and psychological symptoms OT - caregiver burden OT - dementia OT - quality of life EDAT- 2019/04/27 06:00 MHDA- 2020/03/14 06:00 CRDT- 2019/04/27 06:00 PHST- 2019/01/07 00:00 [received] PHST- 2019/04/20 00:00 [accepted] PHST- 2019/04/27 06:00 [pubmed] PHST- 2020/03/14 06:00 [medline] PHST- 2019/04/27 06:00 [entrez] AID - 10.1002/gps.5126 [doi] PST - ppublish SO - Int J Geriatr Psychiatry. 2019 Oct;34(10):1378-1385. doi: 10.1002/gps.5126. Epub 2019 May 8.