PMID- 31025910
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 30
IP  - 10
DP  - 2019 Jul
TI  - Host-guest supramolecular hydrogel based on nanoparticles: co-delivery of DOX and 
      siBcl-2 for synergistic cancer therapy.
PG  - 877-893
LID - 10.1080/09205063.2019.1612602 [doi]
AB  - Synergistic therapy that combines drug/siRNA for the solid tumor treatment is 
      becoming more and more popular to reduce the side effects and enhance the 
      antitumor efficiency. Given that, a novel injectable supramolecular hydrogel 
      mPECT(D)/GDDC-4(R)/alpha-CD(gel) (mPECT(D) represents DOX-loaded methoxy 
      poly(ethylene 
      glycol)-b-poly(epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-un-decanone) (mPECT) 
      nanoparticles, GDDC-4(R) represents siBcl-2-loaded PG-P(DPAx-co-DMAEMAy)-PCB 
      (GDDC-4) complexes nanoparticles (NPs)) was prepared via the incorporation of 
      GDDC-4/siRNA complexes NPs into the DOX-loaded mPECT NPs/alpha-CD(gel) formed by the 
      host-guest interaction between mPEG and alpha-CD. In vitro degradation and release 
      experiments revealed that siBcl-2 was released from mPECT(D)/GDDC-4(R)/alpha-CD(gel) 
      in the form of GDDC-4/siBcl-2 complexes NPs with bioactivity, and the release 
      behavior of DOX also demonstrated sustained-release property. Compared to the 
      single treatment groups, the enhanced cytotoxicity to SKOV3 and HeLa cells of 
      mPECT(D)/GDDC-4(R)/alpha-CD(gel) was observed in vitro. Moreover, in vivo experiments 
      also indicated the significant antitumor effect of mPECT(D)/GDDC-4(R)/alpha-CD(gel), 
      suggesting the remarkable synergistic therapy of DOX and siBcl-2. Therefore, this 
      work would provide a prospective platform to co-delivery of drugs and siRNA to 
      improve the treatment effect of solid tumor.
FAU - Peng, Dan
AU  - Peng D
AD  - a Department of Polymer Science and Technology, Key Laboratory of Systems 
      Bioengineering of the Ministry of Education , School of Chemical Engineering and 
      Technology, Tianjin University , Tianjin , China.
FAU - Gao, Huijie
AU  - Gao H
AD  - b Tianjin Life Science Research Center and School of basic medical sciences , 
      Tianjin Medical University , Tianjin , China.
FAU - Huang, Pingsheng
AU  - Huang P
AD  - c Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical 
      Engineering , Chinese Academy of Medical Sciences and Peking Union Medical 
      College , Tianjin , China.
FAU - Shi, Xiaoguang
AU  - Shi X
AD  - c Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical 
      Engineering , Chinese Academy of Medical Sciences and Peking Union Medical 
      College , Tianjin , China.
FAU - Zhou, Junhui
AU  - Zhou J
AD  - a Department of Polymer Science and Technology, Key Laboratory of Systems 
      Bioengineering of the Ministry of Education , School of Chemical Engineering and 
      Technology, Tianjin University , Tianjin , China.
FAU - Zhang, Jianhua
AU  - Zhang J
AD  - a Department of Polymer Science and Technology, Key Laboratory of Systems 
      Bioengineering of the Ministry of Education , School of Chemical Engineering and 
      Technology, Tianjin University , Tianjin , China.
FAU - Dong, Anjie
AU  - Dong A
AD  - a Department of Polymer Science and Technology, Key Laboratory of Systems 
      Bioengineering of the Ministry of Education , School of Chemical Engineering and 
      Technology, Tianjin University , Tianjin , China.
AD  - d Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , 
      Tianjin , China.
FAU - Tang, Hua
AU  - Tang H
AD  - b Tianjin Life Science Research Center and School of basic medical sciences , 
      Tianjin Medical University , Tianjin , China.
FAU - Wang, Weiwei
AU  - Wang W
AD  - c Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical 
      Engineering , Chinese Academy of Medical Sciences and Peking Union Medical 
      College , Tianjin , China.
FAU - Deng, Liandong
AU  - Deng L
AD  - a Department of Polymer Science and Technology, Key Laboratory of Systems 
      Bioengineering of the Ministry of Education , School of Chemical Engineering and 
      Technology, Tianjin University , Tianjin , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190511
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Hydrogels)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (RNA, Small Interfering)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*chemistry/pharmacology
MH  - Doxorubicin/*chemistry/pharmacology
MH  - Drug Carriers/*chemistry
MH  - HeLa Cells
MH  - Humans
MH  - Hydrogels/*chemistry
MH  - Mice
MH  - Nanoparticles/*chemistry
MH  - Proto-Oncogene Proteins c-bcl-2/deficiency/*genetics
MH  - RNA, Small Interfering/*chemistry/genetics
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - DOX
OT  - Supramolecular hydrogel
OT  - nanoparticles
OT  - siBcl-2
OT  - synergistic therapy
EDAT- 2019/04/27 06:00
MHDA- 2020/05/19 06:00
CRDT- 2019/04/27 06:00
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/04/27 06:00 [entrez]
AID - 10.1080/09205063.2019.1612602 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2019 Jul;30(10):877-893. doi: 
      10.1080/09205063.2019.1612602. Epub 2019 May 11.