PMID- 31025954
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1929-0748 (Print)
IS  - 1929-0748 (Electronic)
IS  - 1929-0748 (Linking)
VI  - 8
IP  - 4
DP  - 2019 Apr 26
TI  - Introducing a New Algorithm for Classification of Etiology in Studies on 
      Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children 
      for Enhanced Diagnostics Study.
PG  - e12705
LID - 10.2196/12705 [doi]
LID - e12705
AB  - BACKGROUND: There is a need to better distinguish viral infections from 
      antibiotic-requiring bacterial infections in children presenting with clinical 
      community-acquired pneumonia (CAP) to assist health care workers in decision 
      making and to improve the rational use of antibiotics. OBJECTIVE: The overall aim 
      of the Trial of Respiratory infections in children for ENhanced Diagnostics 
      (TREND) study is to improve the differential diagnosis of bacterial and viral 
      etiologies in children aged below 5 years with clinical CAP, by evaluating 
      myxovirus resistance protein A (MxA) as a biomarker for viral CAP and by 
      evaluating an existing (multianalyte point-of-care antigen detection test system 
      [mariPOC respi] ArcDia International Oy Ltd.) and a potential future 
      point-of-care test for respiratory pathogens. METHODS: Children aged 1 to 59 
      months with clinical CAP as well as healthy, hospital-based, asymptomatic 
      controls will be included at a pediatric emergency hospital in Stockholm, Sweden. 
      Blood (analyzed for MxA and C-reactive protein) and nasopharyngeal samples 
      (analyzed with real-time polymerase chain reaction as the gold standard and 
      antigen-based mariPOC respi test as well as saved for future analyses of a novel 
      recombinase polymerase amplification-based point-of-care test for respiratory 
      pathogens) will be collected. A newly developed algorithm for the classification 
      of CAP etiology will be used as the reference standard. RESULTS: A pilot study 
      was performed from June to August 2017. The enrollment of study subjects started 
      in November 2017. Results are expected by the end of 2019. CONCLUSIONS: The 
      findings from the TREND study can be an important step to improve the management 
      of children with clinical CAP. INTERNATIONAL REGISTERED REPORT IDENTIFIER 
      (IRRID): DERR1-10.2196/12705.
CI  - (c)Samuel Arthur Rhedin, Annika Eklundh, Malin Ryd-Rinder, Pontus Naucler, Andreas 
      Martensson, Jesper Gantelius, Ingela Zenk, Helene Andersson-Svahn, Susanna 
      Nybond, Reza Rasti, Magnus Lindh, Maria Andersson, Ville Peltola, Matti Waris, 
      Tobias Alfven. Originally published in JMIR Research Protocols 
      (http://www.researchprotocols.org), 26.04.2019.
FAU - Rhedin, Samuel Arthur
AU  - Rhedin SA
AUID- ORCID: 0000-0001-5798-2875
AD  - Sachs' Children and Youth Hospital, South General Hospital, Stockholm, Sweden.
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Insitutet, 
      Stockholm, Sweden.
FAU - Eklundh, Annika
AU  - Eklundh A
AUID- ORCID: 0000-0003-0482-4851
AD  - Sachs' Children and Youth Hospital, South General Hospital, Stockholm, Sweden.
FAU - Ryd-Rinder, Malin
AU  - Ryd-Rinder M
AUID- ORCID: 0000-0002-2947-4117
AD  - Astrid Lindgren Children's Hospital, Stockholm, Sweden.
FAU - Naucler, Pontus
AU  - Naucler P
AUID- ORCID: 0000-0002-8185-2648
AD  - Division of Infectious Diseases, Department of Medicine, Solna, Karolinska 
      Institutet & Department of Infectious Diseases, Karolinska University Hospital, 
      Stockholm, Sweden.
FAU - Martensson, Andreas
AU  - Martensson A
AUID- ORCID: 0000-0001-7504-8365
AD  - Department of Women's and Children's Health, International Maternal and Child 
      Health (IMCH), Uppsala University, Uppsala, Sweden.
FAU - Gantelius, Jesper
AU  - Gantelius J
AUID- ORCID: 0000-0002-2581-1542
AD  - Science for Life Laboratory, Division of Proteomics and Nanobiotechnology, KTH 
      Royal Institute of Technology, Stockholm, Sweden.
FAU - Zenk, Ingela
AU  - Zenk I
AUID- ORCID: 0000-0002-9348-7369
AD  - Sachs' Children and Youth Hospital, South General Hospital, Stockholm, Sweden.
FAU - Andersson-Svahn, Helene
AU  - Andersson-Svahn H
AUID- ORCID: 0000-0003-3409-276X
AD  - Science for Life Laboratory, Division of Proteomics and Nanobiotechnology, KTH 
      Royal Institute of Technology, Stockholm, Sweden.
FAU - Nybond, Susanna
AU  - Nybond S
AUID- ORCID: 0000-0002-7781-2299
AD  - Science for Life Laboratory, Division of Proteomics and Nanobiotechnology, KTH 
      Royal Institute of Technology, Stockholm, Sweden.
FAU - Rasti, Reza
AU  - Rasti R
AUID- ORCID: 0000-0001-7816-8338
AD  - Sachs' Children and Youth Hospital, South General Hospital, Stockholm, Sweden.
AD  - Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
FAU - Lindh, Magnus
AU  - Lindh M
AUID- ORCID: 0000-0002-8729-7462
AD  - Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.
FAU - Andersson, Maria
AU  - Andersson M
AUID- ORCID: 0000-0003-0005-7114
AD  - Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.
FAU - Peltola, Ville
AU  - Peltola V
AUID- ORCID: 0000-0003-3529-2747
AD  - Department of Paediatrics and Adolescent Medicine, Turku University Hospital and 
      University of Turku, Turku, Finland.
FAU - Waris, Matti
AU  - Waris M
AUID- ORCID: 0000-0002-6747-0889
AD  - Department of Paediatrics and Adolescent Medicine, Turku University Hospital and 
      University of Turku, Turku, Finland.
FAU - Alfven, Tobias
AU  - Alfven T
AUID- ORCID: 0000-0002-2328-3512
AD  - Sachs' Children and Youth Hospital, South General Hospital, Stockholm, Sweden.
AD  - Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20190426
PL  - Canada
TA  - JMIR Res Protoc
JT  - JMIR research protocols
JID - 101599504
PMC - PMC6658235
OTO - NOTNLM
OT  - child, preschool
OT  - diagnostic tests, routine
OT  - microbiological techniques
OT  - pneumonia
OT  - respiratory tract infections
COIS- Conflicts of Interest: None declared.
EDAT- 2019/04/27 06:00
MHDA- 2019/04/27 06:01
PMCR- 2019/04/26
CRDT- 2019/04/27 06:00
PHST- 2018/11/18 00:00 [received]
PHST- 2019/03/24 00:00 [accepted]
PHST- 2019/03/09 00:00 [revised]
PHST- 2019/04/27 06:00 [entrez]
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2019/04/27 06:01 [medline]
PHST- 2019/04/26 00:00 [pmc-release]
AID - v8i4e12705 [pii]
AID - 10.2196/12705 [doi]
PST - epublish
SO  - JMIR Res Protoc. 2019 Apr 26;8(4):e12705. doi: 10.2196/12705.