PMID- 31026478
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20200511
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 491
DP  - 2019 Jul 1
TI  - Alternative retinoid X receptor (RXR) ligands.
PG  - 110436
LID - S0303-7207(19)30124-8 [pii]
LID - 10.1016/j.mce.2019.04.016 [doi]
AB  - Retinoid X receptors (RXRs) control a wide variety of functions by virtue of 
      their dimerization with other nuclear hormone receptors (NRs), contributing 
      thereby to activities of different signaling pathways. We review known RXR 
      ligands as transcriptional modulators of specific RXR-dimers and the associated 
      biological processes. We also discuss the physiological relevance of such 
      ligands, which remains frequently a matter of debate and which at present is best 
      met by member(s) of a novel family of retinoids, postulated as Vitamin A5. 
      Through comparison with other natural, but also with synthetic ligands, we 
      discuss high diversity in the modes of ligand binding to RXRs resulting in 
      agonistic or antagonistic profiles and selectivity towards specific subtypes of 
      permissive heterodimers. Despite such diversity, direct ligand binding to the 
      ligand binding pocket resulting in agonistic activity was preferentially 
      preserved in the course of animal evolution pointing to its functional relevance, 
      and potential for existence of other, species-specific endogenous RXR ligands 
      sharing the same mode of function.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Krezel, Wojciech
AU  - Krezel W
AD  - Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France; 
      Centre National de la Recherche Scientifique, UMR 7104, Illkirch, France; 
      Institut National de la Sante et de la Recherche Medicale, U 1258, Illkirch, 
      France; Universite de Strasbourg, Illkirch, France. Electronic address: 
      krezel@igbmc.fr.
FAU - Ruhl, Ralph
AU  - Ruhl R
AD  - Paprika Bioanalytics BT, Debrecen, Hungary.
FAU - de Lera, Angel R
AU  - de Lera AR
AD  - Departamento de Quimica Organica, Facultade de Quimica, Lagoas-Marcosende, 36310, 
      Vigo, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190423
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Ligands)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Ligands
MH  - Receptors, Cytoplasmic and Nuclear/*metabolism
MH  - Retinoid X Receptors/*metabolism
MH  - Retinoids/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - DHA
OT  - Evolution
OT  - Polyunsaturated fatty acids
OT  - Retinoid X receptor
OT  - Retinoids
OT  - Rexinoids
EDAT- 2019/04/27 06:00
MHDA- 2020/05/12 06:00
CRDT- 2019/04/27 06:00
PHST- 2019/02/15 00:00 [received]
PHST- 2019/04/06 00:00 [revised]
PHST- 2019/04/22 00:00 [accepted]
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2019/04/27 06:00 [entrez]
AID - S0303-7207(19)30124-8 [pii]
AID - 10.1016/j.mce.2019.04.016 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2019 Jul 1;491:110436. doi: 10.1016/j.mce.2019.04.016. Epub 
      2019 Apr 23.