PMID- 31026511
OWN - NLM
STAT- MEDLINE
DCOM- 20191120
LR  - 20191120
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Linking)
VI  - 191
DP  - 2019 Jul
TI  - Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark 
      sides.
PG  - 105368
LID - S0960-0760(19)30172-4 [pii]
LID - 10.1016/j.jsbmb.2019.04.017 [doi]
AB  - The brain is isolated from the whole body by the blood-brain barrier (BBB) which 
      is located in brain microvessel endothelial cells (ECs). Through physical and 
      metabolic properties induced by brain pericytes, astrocytes and neurons (these 
      cells and the ECs referred to as the neurovascular unit (NVU)), the BBB hardly 
      restricts exchanges of molecules between the brain and the bloodstream. Among 
      them, cholesterol exchanges between these two compartments are very limited and 
      occur through the transport of LDLs across the BBB. Oxysterols (mainly 24S and 
      27-hydroxycholesterol) daily cross the BBB and regulate molecule/cholesterol 
      exchanges via Liver X nuclear Receptors (LXRs). In addition, these oxysterols 
      have been linked to pathological processes in neurodegenerative diseases such as 
      Alzheimer's disease. Here we propose an overview of the actual knowledge 
      concerning oxysterols and the NVU cells in physiological and in Alzheimer's 
      disease.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Saint-Pol, Julien
AU  - Saint-Pol J
AD  - University of Artois, Blood-Brain Barrier Laboratory (BBB Lab), EA2465, F-62300 
      Lens, France. Electronic address: julien.saintpol@univ-artois.fr.
FAU - Gosselet, Fabien
AU  - Gosselet F
AD  - University of Artois, Blood-Brain Barrier Laboratory (BBB Lab), EA2465, F-62300 
      Lens, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190423
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Oxysterols)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Alzheimer Disease/*metabolism/pathology
MH  - Animals
MH  - Blood-Brain Barrier/*metabolism/pathology
MH  - Capillary Permeability
MH  - Cholesterol/*metabolism
MH  - Endothelial Cells/metabolism/pathology
MH  - Homeostasis
MH  - Humans
MH  - Neurons/metabolism/pathology
MH  - Oxysterols/*metabolism
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Blood-Brain Barrier
OT  - Cholesterol homeostasis
OT  - Neurovascular unit
OT  - Oxysterols
EDAT- 2019/04/27 06:00
MHDA- 2019/11/21 06:00
CRDT- 2019/04/27 06:00
PHST- 2019/03/21 00:00 [received]
PHST- 2019/04/10 00:00 [revised]
PHST- 2019/04/22 00:00 [accepted]
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2019/11/21 06:00 [medline]
PHST- 2019/04/27 06:00 [entrez]
AID - S0960-0760(19)30172-4 [pii]
AID - 10.1016/j.jsbmb.2019.04.017 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2019 Jul;191:105368. doi: 
      10.1016/j.jsbmb.2019.04.017. Epub 2019 Apr 23.